Introducing descending control of nociception: a measure of diffuse noxious inhibitory controls in conscious animals

Bannister, Kirsty; Kucharczyk, M.; Graven‐Nielsen, Thomas; Porreca, Frank

doi:10.1097/j.pain.0000000000002203

Cited by 25 publications

(28 citation statements)

References 38 publications

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“…Although the hindpaw tissue is not directly injured by the UCS, the sensitivity of the hindpaw may increase due to a recently described phenomenon ( Tansley et al, 2019 ) that we are calling hyperalgesic descending control of nociception (DCN), which represents the opposite of classical analgesic DCN (previously known as diffuse noxious inhibitory controls [DNIC] or conditioned pain modulation [CPM]). We use this term to describe the process by which pain in one region of an animal’s body increases pain in another anatomically distinct region via descending pain modulatory circuitry ( Bannister et al, 2021 ). Hindpaw sensitivity was measured in both contexts on days 1 and 4 of the experiment, 45 min following acetic acid injection.…”

Section: Resultsmentioning

confidence: 99%

Contextual control of conditioned pain tolerance and endogenous analgesic systems

Trask

Mogil

Helmstetter

et al. 2022

eLife

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The mechanisms underlying the transition from acute to chronic pain are unclear but may involve the persistence or strengthening of pain memories acquired in part through associative learning. Contextual cues, which comprise the environment in which events occur, were recently described as a critical regulator of pain memory; both male rodents and humans exhibit increased pain sensitivity in environments recently associated with a single painful experience. It is unknown, however, how repeated exposure to an acute painful unconditioned stimulus in a distinct context modifies pain sensitivity or the expectation of pain in that environment. To answer this question, we conditioned mice to associate distinct contexts with either repeated administration of a mild visceral pain stimulus (intraperitoneal injection of acetic acid) or vehicle injection over the course of three days. On the final day of experiments animals received either an acid injection or vehicle injection prior to being placed into both contexts. In this way, contextual control of pain sensitivity and pain expectation could be tested respectively. When re-exposed to the noxious stimulus in a familiar environment, both male and female mice exhibited context-dependent conditioned analgesia, a phenomenon mediated by endogenous opioid signaling. However, when expecting the presentation of a painful stimulus in a given context, males exhibited conditioned hypersensitivity whereas females exhibited endogenous opioid-mediated conditioned analgesia. These results are evidence that pain perception and engagement of endogenous opioid systems can be modified through their psychological association with environmental cues. Successful determination of the brain circuits involved in this sexually dimorphic anticipatory response may allow for the manipulation of pain memories, which may contribute to the development of chronic pain states.

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Section: Resultsmentioning

confidence: 99%

Contextual control of conditioned pain tolerance and endogenous analgesic systems

Trask

Mogil

Helmstetter

et al. 2022

eLife

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“…There are distinctive mechanisms behind modulation of nociception and modulation of pain, and recent studies have uncovered that certain contexts or stimuli can modulate pain report while keeping nociceptive reflexes unchanged (Morélot-Panzini et al, 2014;Rhudy et al, 2006Rhudy et al, , 2006Yashiro et al, 2011), and vice versa, where nociceptive reflexes are modulated but pain report is unchanged (Rhudy et al, 2018)). Therefore, in animals where the distinction of pain and nociception has not yet been explored experimentally, it has been suggested we refer to descending control of pain as "descending control of nociception" (Bannister et al, 2021). We will adopt this terminology in this review.…”

Section: Descending Control Of Nociceptionmentioning

confidence: 99%

Descending Control of Nociception in Insects?

Gibbons¹,

Sarlak²,

Chittka³

2022

Preprint

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Modulation of nociception allows animals to prioritise their survival by adapting their behaviour in different contexts. In mammals, this is executed by neurons from the brain, and is referred to as the descending control of nociception. Whether insects have this control, or have the neural circuits underpinning it, has not been clarified. Here, we review evidence supporting descending control of nociception control in insects, and consider which neuronal sub-types and brain areas may be involved.

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“…Spinal WDRs [17] Halotane [10] Isoflurane [7] Medullary WDRs [10] Halotane [9] Urethane [1] Halotane [1] Sevoflurane [2] Urethane [1] Awake [11] Halotane [1] Urethane [1] Electrophysiology [27] PHARMACOLOGICAL STUDIES [42] Electromyography [4] Behaviour [12] Immunohistochemistry [1] READOUT ↓ the serotoninergic system, 11 on the noradrenergic system, 9 on the opioidergic system, and 10 on other systems (Table 1). The most recurrent were studies of systemically administered morphine (µ-and δ-opioid receptor (MOR and DOR, respectively) agonist) (9 studies), followed by investigation of the systemic actions of naloxone (a non-selective opioid receptors antagonist) (7 studies), and investigation of citalopram, escitalopram, duloxetine or fluoxetine (selective serotonin reuptake inhibitors (SSRI)) (4 studies).…”

Section: Anaesthesiamentioning

confidence: 99%

“…A reduction in pain-like behaviours upon application/administration of a conditioning stimulus evidently portrays execution of distinct top down modulatory processes compared to measurement of a functional DNIC response in anaesthetised animals. 1 Explicitly, the subject's conscious state now encompasses cognitive inputs that will impact the response observed upon conditioning. That said the functional expression of DNIC was previously shown modulated by pharmacological manipulation of subcortical brain regions 26 bolstering a hypothesised scenario whereby DCN may involve DNIC mechanisms, but not the other way round.…”

Section: Systemic Pharmacological Administrationmentioning

confidence: 99%

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Developments in Understanding Diffuse Noxious Inhibitory Controls: Pharmacological Evidence from Pre-Clinical Research

Kucharczyk¹,

Valiente²,

Bannister³

2021

JPR

Self Cite

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Bulbospinal pathways regulate nociceptive processing, and inhibitory modulation of nociception can be achieved via the activity of diffuse noxious inhibitory controls (DNIC), a unique descending pathway activated upon application of a conditioning stimulus (CS). Numerous studies have investigated the effects of varied pharmacological systems on the expression status of a) DNIC (as measured in anaesthetised animals) and b) the descending control of nociception (DCN), a surrogate measure of DNIC-like effects in conscious animals. However, the complexity of the underlying circuitry that governs initiation of a top-down inhibitory response in reaction to a CS, coupled with the methodological limitations associated with using pharmacological tools for its study, has often obscured the exact role(s) of a given drug. In this literature review, we discuss the pharmacological manipulation interrogation strategies that have hitherto been used to examine the functionality of DNIC and DCN. Discreet administration of a substance in the spinal cord or brain is considered in the context of action on one of four hypothetical systems that underlie the functionality of DNIC/DCN, where interpreting the outcome is often complicated by overlapping qualities. Systemic pharmacological modulation of DNIC/DCN is also discussed despite the fact that the precise location of drug action(s) cannot be pinpointed. Chiefly, modulation of the noradrenergic, serotonergic and opioidergic transmission systems impacts DNIC/DCN in a manner that relates to drug class, route of administration and health/disease state implicated. The advent of increasingly sophisticated interrogation tools will expedite our full understanding of the circuitries that modulate naturally occurring pain-inhibiting pathways.

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Introducing descending control of nociception: a measure of diffuse noxious inhibitory controls in conscious animals

Cited by 25 publications

References 38 publications

Contextual control of conditioned pain tolerance and endogenous analgesic systems

Contextual control of conditioned pain tolerance and endogenous analgesic systems

Descending Control of Nociception in Insects?

Developments in Understanding Diffuse Noxious Inhibitory Controls: Pharmacological Evidence from Pre-Clinical Research

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