Intrinsic structural covariation links cerebellum subregions to the cerebral cortex

Wang, Zilong; Diedrichsen, Jörn; Saltoun, Karin; Steele, Christopher; Arnold-Anteraper, Sheeba Rani; Yeo, B.T. Thomas; Schmahmann, Jeremy; Bzdok, Danilo

doi:10.1101/2024.02.16.580701

Cited by 3 publications

(1 citation statement)

References 187 publications

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“…Cerebro-cerebellar connectivity has been studied in animal models using tract tracing (Kelly and Strick 2003) and in vivo in humans using tractographic methods (Palesi et al 2017;Stockert et al 2021), wholebrain structural covariation modelling (Wang et al 2024), and resting-state (Buckner et al 2011) and taskbased functional connectivity analyses (Harry et al 2023). In addition to motor connectivity these have revealed widespread activity in non-motor areas, including prefrontal and posterior parietal cortex (Stoodly and Schmahmann 2009; Ramnini 2020).…”

Section: Introductionmentioning

confidence: 99%

EEG-ECeG coherence mapping of human cerebro-cerebellar projections

Todd,

Govender,

Hochstrasser

et al. 2024

Preprint

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The cerebellar and cerebral cortices are powerfully connected via reciprocal, crossed projections which mediate their coordination in motor, cognitive and affective processes. In the present paper we demonstrate non-invasive imaging of crossed cerebro-cerebellar connectivity by means of wavelet coherence. In a sample of six healthy adult subjects, we recorded EEG and the electro-cerebellogram (ECeG) with a 10% cerebellar extension montage during voluntary left and right index finger and foot movements. EMG was also recorded from finger extensors and flexors and from the tibialis anterior and soleus muscles and was used to generate triggers for movement related averaging (-2000 to + 2000 ms). Wavelet power and EEG-ECeG coherence were computed over the 4 s epoch for each electrode and for statistical analysis both cerebral and cerebellar grids centred around Cz and SIz. Movement related changes were observed in both cerebral and cerebellar power, most significantly in the high delta band (1.5 to 3 Hz). Significant movement related change in d-band EEG-ECeG coherence was also observed and to a lesser extent a-decoherence. Of particular note, when lateralised seeds were selected (C1 vs C2 and PO11 vs PO12) the low-frequency (d, q, a, b) coherence was distributed contralaterally for both cerebral and cerebellar seeds, likely reflecting the underlying crossed cerebro-cerebellar projections. However, the two projections differed in their spatial distribution whereby the cerebellar (PO11/PO12) seeded coherence was concentrated towards the cerebral midline while the cerebral (C1/C2) seeded coherence was distributed away from the cerebellar midline. The cerebral (C1/C2) seeded coherence also extended anteriorly to temporal leads suggestive of temporal lobe involvement. Evidence was also apparent of a distinct high-frequency (VHF/UHF) crossed projection which differed again in its spatial distribution. These findings further support the value of recording cerebellar ECeG and demonstrate its potential to contribute to the understanding of cerebro-cerebellar function and dysfunction.

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Section: Introductionmentioning

confidence: 99%

EEG-ECeG coherence mapping of human cerebro-cerebellar projections

Todd,

Govender,

Hochstrasser

et al. 2024

Preprint

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Cerebellar Roles in Motor and Social Functions and Implications for ASD

Sivalingam,

Pandian

2024

Cerebellum

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Insights into the genetic architecture of cerebellar lobules derived from the UK Biobank

Carrión-Castillo,

Boeckx

2024

Sci Rep

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In this work we endeavor to further understand the genetic architecture of the cerebellum by examining the genetic underpinnings of the different cerebellar lob(ul)es, identifying their genetic relation to cortical and subcortical regions, as well as to psychiatric disorders, as well as traces of their evolutionary trajectories. We confirm the moderate heritability of cerebellar volumes, and reveal genetic clustering and variability across their different substructures, which warranted a detailed analysis using this higher structural resolution. We replicated known genetic correlations with several subcortical volumes, and report new cortico-cerebellar genetic correlations, including negative genetic correlations between anterior cerebellar lobules and cingulate, and positive ones between lateral Crus I and lobule VI with cortical measures in the fusiform region. Heritability partitioning for evolutionary annotations highlighted that the vermis of Crus II has depleted heritability in genomic regions of “archaic introgression deserts”, but no enrichment/depletion of heritability in any other cerebellar regions. Taken together, these findings reveal novel insights into the genetic underpinnings of the different cerebellar lobules.

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Intrinsic structural covariation links cerebellum subregions to the cerebral cortex

Cited by 3 publications

References 187 publications

EEG-ECeG coherence mapping of human cerebro-cerebellar projections

EEG-ECeG coherence mapping of human cerebro-cerebellar projections

Cerebellar Roles in Motor and Social Functions and Implications for ASD

Insights into the genetic architecture of cerebellar lobules derived from the UK Biobank

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