Intrinsic sinus and atrioventricular node electrophysiologic adaptations in endurance athletes

Stein, Ricardo; Medeiros, Cássia Regina Gotler; Rosito, Guido A.; Zimerman, Leandro Ioschpe; Ribeiro, Jorge Pinto

doi:10.1016/s0735-1097(02)01722-9

Cited by 176 publications

(124 citation statements)

References 25 publications

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“…Consequently, ACh does not seem to be implicated in the A-V conduction system refractoriness increase produced by physical training. These results are consistent with Stein et al (37), which found that atrioventricular node effective refractory period in athletes was longer than in untrained individuals even after pharmacological blockade, indicating that these changes were caused by intrinsic electrophysiological modifications. Neither physical training nor parasympathetic blockade modified retrograde conduction system refractoriness.…”

Section: Refractoriness and Parasympathetic Blockadesupporting

confidence: 92%

“…These results are partially in accordance with those previously obtained in human (20,19,6,36,37) and experimental studies (28,27,38,39). Nevertheless, muscarinic receptor blockade with atropine did not modify the negative chronotropic and dromotropic effects produced by physical training.…”

Section: Effect Of Parasympathetic Blockade On Automatism and Conductionsupporting

confidence: 92%

“…It has been proposed that these modifications are the result of an increased resting vagal tone (5,33,34). However, data presented by several investigations in which sympathetic and parasympathetic blockade was performed after an exercise training period have shown a decrease in the intrinsic heart rate (20,19,27,6,37) and an intrinsic atrioventricular conduction depression (37). Furthermore, similar results have been obtained in experimental models using isolated heart preparations not only on sinus chronotropism (28,38,39) and atrioventricular node conduction (38), but also on ventricular refractoriness, which increased by training (38,39).…”

Section: Introductionmentioning

confidence: 99%

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The training-induced changes on automatism, conduction and myocardial refractoriness are not mediated by parasympathetic postganglionic neurons activity

et al. 2011

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The purpose of this study is to test the role that the intrinsic parasympathetic nervous system could play on the adaptive electrophysiological changes produced by physical training on intrinsic myocardial automatism, conduction and refractoriness. Trained rabbits were submitted to a physical training protocol on a treadmill for six weeks. The electrophysiological study was performed on an isolated heart preparation. The

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Section: Refractoriness and Parasympathetic Blockadesupporting

confidence: 92%

Section: Effect Of Parasympathetic Blockade On Automatism and Conductionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

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The training-induced changes on automatism, conduction and myocardial refractoriness are not mediated by parasympathetic postganglionic neurons activity

et al. 2011

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“…In addition to anatomical changes, endurance training may also cause different functional changes, such as arrhythmias and abnormalities in atrioventricular conduction. Sinus bradycardia is often affiliated with increased vagal activity, but can also be related to intrinsic electrophysiological adaptations of sinus node automaticity (Stein et al 2002).…”

Section: Hrv and Endurance Trainingmentioning

confidence: 99%

Heart rate variability is related to training load variables in interval running exercises

Kaikkonen¹,

Hynynen

Mann

et al. 2011

Eur J Appl Physiol

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“…The present study also indicates alterations in the autonomic control of the heart as it was evident by HRV analysis. However, similar type of studies on animals and humans involving autonomic blockade have related the resting bradycardia to reduced intrinsic heart rate [10,13].…”

Section: Discussionmentioning

confidence: 99%

Time domain and frequency domain analysis of heart rate variability in elite Nepalese football players

Sharma¹,

Paudel²,

Khadka³

et al. 2015

Int Jour of Biomed Res

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Objective: There are conflicting reports in the literature concerning the time and frequency domain parameters of heart rate variability (HRV) in athletes. Furthermore, the exact impact of different sports disciplines on cardiac autonomic function is unclear. Thus, the study was destined to assess and compare HRV in the time and frequency domains between elite Nepalese football players and non-athletes. Methods: Temporal and spectral HRV parameters determined from 5-minute continuous ECG during supine rest were studied in 27 elite male football players (age: 22.74±2.52 years) with excellent cardiorespiratory fitness, and 30 non-athletic male (age: 23.41±2.95 years) volunteers (control group). All HRV parameters were compared between the groups. Results: Resting heart rate, systolic and diastolic blood pressure were significantly lower and all parasympathetic-related time and frequency domain indices, including root mean square of successive differences [RMSSD, [HFnu,)%, p=0.001]), were higher in footballers compared to non-athletics. Similarly, standard deviation of all NN intervals (SDNN), determinant of global HRV, was higher in players (p=0.003). Furthermore, the power spectral components low frequency in normalized unit (LFnu), a sympathetic marker, and LF/HF, which reflect sympatho-vagal balance, were significantly lower in players. Conclusion: The footballers had enhanced parasympathetic (higher RMSSD, HF and HFnu, and lower LF/HF ratio) and diminished sympathetic (lower LFnu) tone on heart. Football playing has favorable effect on the cardiac autonomic profile as indicated by high global HRV (higher SDNN).

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Intrinsic sinus and atrioventricular node electrophysiologic adaptations in endurance athletes

Abstract: Under double-pharmacologic blockade, we demonstrated that sinus automaticity and AV node conduction changes of endurance athletes are related to intrinsic physiology and not to autonomic influences.

Cited by 176 publications

References 25 publications

The training-induced changes on automatism, conduction and myocardial refractoriness are not mediated by parasympathetic postganglionic neurons activity

The training-induced changes on automatism, conduction and myocardial refractoriness are not mediated by parasympathetic postganglionic neurons activity

Heart rate variability is related to training load variables in interval running exercises

Time domain and frequency domain analysis of heart rate variability in elite Nepalese football players

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