Intrinsic signal imaging of brain function using a small implantable CMOS imaging device

Haruta, Makito; Sunaga, Yoshinori; Yamaguchi, Takahiro; Takehara, Hironari; Noda, Toshihiko; Sasagawa, Kiyotaka; Tokuda, Takashi; Ohta, Jun

doi:10.7567/jjap.54.04dl10

Cited by 20 publications

(14 citation statements)

References 31 publications

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“…The velocities were 0.88 mm/s, 1.13 mm/s, and 1.22 mm/s. w was difficult [10,11] This device could simultaneously measure the blood-flow velocity and brain activity. These results suggested that the chronic brain blood-flow imaging device could be used for the development of a therapeutic methods for cerebrovascular disease [21].…”

Section: Conditions Of the Mouse Cerebral Surface With The Chronic Rementioning

confidence: 99%

“…In long-term experiments, the implanted device moved in the brain, and the imaging area was obstructed. Additionally, these devices [10,11] did not observe brain-surface images for a long time, because the structures of the devices damaged the brain surface. In this study, a blood-flow imaging device was developed for long-term and repeated behavioral experiments with the same small experimental animal.…”

Section: Introductionmentioning

confidence: 99%

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Chronic brain blood-flow imaging device for a behavioral experiment using mice

Haruta

Kurauchi

Ohsawa

et al. 2019

Biomed. Opt. Express

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A chronic brain blood-flow imaging device was developed for cerebrovascular disease treatment. This device comprises a small complementary metal-oxide semiconductor image sensor and a chronic fiber-optic plate window on a mouse head. A long-term cerebral blood-flow imaging technique was established in a freely moving mouse. Brain surface images were visible for one month using the chronic FOP window. This device obtained brain surface images and blood-flow velocity. The blood-flow changes were measured in behavioral experiments using this device. The chronic brain blood-flow imaging device may contribute to determining the cause of cerebrovascular disease and the development of cerebrovascular disease treatment.

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Section: Conditions Of the Mouse Cerebral Surface With The Chronic Rementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Chronic brain blood-flow imaging device for a behavioral experiment using mice

Haruta

Kurauchi

Ohsawa

et al. 2019

Biomed. Opt. Express

Self Cite

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show abstract

“…The required equipment obstructs the animals' natural behavior. An implantable optical imaging device based on complementarymetal-oxide-semiconductor (CMOS) technology is an alternative approach to observe neural activities while moving freely (Ohta et al, 2009(Ohta et al, , 2017Haruta et al, 2015;Takehara et al, 2015). Previously, our group has reported implantable CMOS image sensors for contact imaging, which are ultra-small and lightweight.…”

Section: Introductionmentioning

confidence: 99%

Self-Reset Image Sensor With a Signal-to-Noise Ratio Over 70 dB and Its Application to Brain Surface Imaging

et al. 2021

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In this study, we propose a complementary-metal-oxide-semiconductor (CMOS) image sensor with a self-resetting system demonstrating a high signal-to-noise ratio (SNR) to detect small intrinsic signals such as a hemodynamic reaction or neural activity in a mouse brain. The photodiode structure was modified from N-well/P-sub to P+/N-well/P-sub to increase the photodiode capacitance to reduce the number of self-resets required to decrease the unstable stage. Moreover, our new relay board was used for the first time. As a result, an effective SNR of over 70 dB was achieved within the same pixel size and fill factor. The unstable state was drastically reduced. Thus, we will be able to detect neural activity. With its compact size, this device has significant potential to become an intrinsic signal detector in freely moving animals. We also demonstrated in vivo imaging with image processing by removing additional noise from the self-reset operation.

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“…MicroLED arrays have been studied for use in other biomedical applications including optogenetic stimulation. [25][26][27] The ORIS device designed and fabricated in this work extends the technology to the application of seizure monitoring using a novel bi-directional configuration on a flexible polyimide substrate capable of localizing spatiotemporal effects of seizures on CBV.…”

Section: Introductionmentioning

confidence: 99%

Localizing Seizure Activity in the Brain Using Implantable Micro‐LEDs with Quantum Dot Downconversion

Choi

Colon-Berrios

Hamachi

et al. 2018

Adv Materials Technologies

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Current methods for high resolution imaging of neural activity, such as functional magnetic resonance imaging and penetrating electrode arrays, are not well suited for chronic patient monitoring in clinical settings. The ability to locally monitor neural activity in the brain would benefit doctors and surgeons treating and diagnosing neurological diseases such as epilepsy. Measurement of the intrinsic optical signal offers a high resolution (better than 100 microns) for the localization of brain activity. The localized detection of seizures in rats using an implantable optical sensor is demonstrated. The implantable optical sensor is fabricated on a 25 µm thick, flexible polyimide substrate and uses microLEDs to measure localized changes in reflectivity due to cerebral blood flow when attached to the surface of the brain. Quantum dot coatings are applied directly to the microLEDs via pneumatic printing for wavelength conversion by photoluminescent re-emission.

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Intrinsic signal imaging of brain function using a small implantable CMOS imaging device

Cited by 20 publications

References 31 publications

Chronic brain blood-flow imaging device for a behavioral experiment using mice

Chronic brain blood-flow imaging device for a behavioral experiment using mice

Self-Reset Image Sensor With a Signal-to-Noise Ratio Over 70 dB and Its Application to Brain Surface Imaging

Localizing Seizure Activity in the Brain Using Implantable Micro‐LEDs with Quantum Dot Downconversion

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