Intrinsic Noise Monitoring of Complex Systems

Szász, Olivér; Szigeti, Gyula P.; Szász, András

doi:10.4236/ojbiphy.2017.74015

Cited by 5 publications

(3 citation statements)

References 21 publications

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“…It can be measured by the frequencies of cyclic astronomical events, such as the rise and fall of the sun in the sky and the changing of the seasons, resulting from the earth rotating around its axis and revolving around the sun, both of which occur independently of organismal size. By contrast, biological (physiological) time clearly depends on an organism’s spatial dimensions, activities, and body temperature [ 3 , 4 , 46 , 59 , 101 , 103 , 109 , 110 , 111 , 112 , 113 , 114 , 115 ]. It can be measured by the frequencies of cyclic cellular, developmental, and physiological events that all scale with organismal size, typically proceeding faster in small vs. large organisms [ 3 , 4 , 42 , 51 , 52 , 104 ].…”

Section: Major Ways That Time May Be Relevant In Biological Scalingmentioning

confidence: 99%

The Relevance of Time in Biological Scaling

Glazier

2023

Biology

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Various phenotypic traits relate to the size of a living system in regular but often disproportionate (allometric) ways. These “biological scaling” relationships have been studied by biologists for over a century, but their causes remain hotly debated. Here, I focus on the patterns and possible causes of the body-mass scaling of the rates/durations of various biological processes and life-history events, i.e., the “pace of life”. Many biologists have regarded the rate of metabolism or energy use as the master driver of the “pace of life” and its scaling with body size. Although this “energy perspective” has provided valuable insight, here I argue that a “time perspective” may be equally or even more important. I evaluate various major ways that time may be relevant in biological scaling, including as (1) an independent “fourth dimension” in biological dimensional analyses, (2) a universal “biological clock” that synchronizes various biological rates/durations, (3) a scaling method that uses various biological time periods (allochrony) as scaling metrics, rather than various measures of physical size (allometry), as traditionally performed, (4) an ultimate body-size-related constraint on the rates/timing of biological processes/events that is set by the inevitability of death, and (5) a geological “deep time” approach for viewing the evolution of biological scaling patterns. Although previously proposed universal four-dimensional space-time and “biological clock” views of biological scaling are problematic, novel approaches using allochronic analyses and time perspectives based on size-related rates of individual mortality and species origination/extinction may provide new valuable insights.

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Section: Major Ways That Time May Be Relevant In Biological Scalingmentioning

confidence: 99%

The Relevance of Time in Biological Scaling

Glazier

2023

Biology

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“…which has an emerging application in physiology [266]. The monitoring of the noise as fluctuations in the complex system could be a factor in its surveillance [267].…”

Section: The Challenge Of Nutritionmentioning

confidence: 99%

Supportive and Palliative Care in Cancer Therapies—Path from Tumor-Driven Therapies to Patient-Driven Ones

Minnaar¹,

Szász²,

Lee³

et al. 2022

IJCM

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Cancer patients frequently report a set of symptoms including fatigue, pain, and physiological and social distress. Families and other personal lay relations give proposals to take supportive drugs and supplemental nutrients, without professional knowledge about their actions. Internet search engines and social networks serve up most of the treatment proposals, opening wide possibilities for quackeries and predatory money-making practices. Medical professionals have a responsibility to clear this field and concentrate on patients' well-being and personal needs. According to our approach, the integration of supportive and palliative care with conventional therapies needs a change of paradigm from tumour-driven to patient-driven treatment actions. Supportive/palliative care includes a broad spectrum of applied methods, including medications, nourishments, electrical effects, and psycho and social supports. Our goal is to discuss the possibilities for combining conventional oncotherapies with additional supportive/palliative care and to give suggestions on a professional basis.

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“…The fluctuations of electrical properties have unique information related to cell-membrane processes [68]. The monitoring of the noise as fluctuations in the complex system could be a factor in its surveillance [69]. Forcing harmony reconstructs the broken E-cadherin-betacatenin cellular connections [70], which as was effectively and repeatedly demonstrated in an independent study [71].…”

Section: The Selection Modementioning

confidence: 99%

The Capacitive Coupling Modalities for Oncological Hyperthermia

Szász¹

2021

OJBIPHY

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The local-regional oncological hyperthermia has various electromagnetic methods for energy-transfer. The differences involve conceptual considerations and technical solutions. The most frequently applied energy transfer is capacitive coupling, concentrating the electric field to be the active heating component. The realization of the capacitive coupling set-up is divided into two different categories based on their goals for heating: 1) the homogeneous (conventional) heating, using isothermal conditions for dosing, and 2) the selective heterogeneous heating, using cellularly absorbed energy for dosing. The homogeneous heating utilizes plane-wave matching, absorbing the wave for energy transfer. The heterogenic heating uses impedance matching, selecting the malignant cells by their electromagnetic specialties, like their heterogenic impedance, higher membrane-raft density, and different spatio-temporal (pathologic pattern) arrangements. This article's objective is to compare and discuss the details of the two kinds of capacitive coupling techniques.

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Intrinsic Noise Monitoring of Complex Systems

Cited by 5 publications

References 21 publications

The Relevance of Time in Biological Scaling

The Relevance of Time in Biological Scaling

Supportive and Palliative Care in Cancer Therapies—Path from Tumor-Driven Therapies to Patient-Driven Ones

The Capacitive Coupling Modalities for Oncological Hyperthermia

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