Intrinsic Neural Control of Intestinal Motility

Wood, Jackie D.

doi:10.1146/annurev.ph.43.030181.000341

Cited by 91 publications

(28 citation statements)

References 49 publications

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“…The surgical procedure used has been described (19)(20)(21). The skull was exposed for the fixation of two small anchor screws which were attached to an electrical plug with dental acrylate.…”

Section: Methodsmentioning

confidence: 99%

Effect of the acupoints ST-36 (Zusanli) and SP-6 (Sanyinjiao) on intestinal myoelectric activity of Wistar rats

Tabosa

Yamamura

Forno

et al. 2002

Braz J Med Biol Res

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Despite its ancient use as a therapeutic tool to treat several ailments, acupuncture still faces the challenge of scrutiny by Western science both in terms of its efficacy and in terms of the characterization of its effects and mechanisms of actions underlying these effects. We investigated under well-controlled and carefully characterized conditions the influence of electrical stimulation of acupuncture points ST-36 (Zusanli) and SP-6 (Sanyinjiao) on the myoelectric activity of the small intestine of 38 adult male Wistar rats. Electrical recordings obtained by means of four electrodes chronically implanted in the small intestine were used to assess the effects of acupuncture (electroacupuncture stimulation set at 2 Hz, intermittent stimulation, 1 V, for 30 min). Immobilization of the animals was associated with a consistent decrease (-8 ± 7%) in the myoelectric activity of the small intestine as measured by means of the root mean square. Conversely, acupuncture was able to significantly increase (overshoot) this activity compared to baseline (+44 ± 7%). In contrast, immobilized animals subjected to sham acupuncture had only modest (nonsignificant) increases in myoelectric activity (+9 ± 6%). Using carefully controlled conditions we confirmed previous noncontrolled studies on the ability of acupuncture to alter intestinal motility. The characterization of the topographic and temporal profiles of the effects observed here represents a basis for future dissection of the physiological and pharmacological systems underlying these effects. Correspondence

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Section: Methodsmentioning

confidence: 99%

Effect of the acupoints ST-36 (Zusanli) and SP-6 (Sanyinjiao) on intestinal myoelectric activity of Wistar rats

Tabosa

Yamamura

Forno

et al. 2002

Braz J Med Biol Res

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“…classified as AH/type 2 neurones, forty-nine were S/type 1 neurones (Hirst, Holman & Spence, 1974;Nishi & North, 1973;Wood, 1981), and thirty-one were either types 3 or 4. Type 3 neurones had low input resistance similar to AH/type 2 neurones, but they did not discharge spikes when depolarized by intracellularly injected current pulses.…”

Section: Histamine Effects On Myenteric Neuronesmentioning

confidence: 99%

Intracellular study of effects of histamine on electrical behaviour of myenteric neurones in guinea‐pig small intestine.

Nemeth¹,

Ort²,

Wood³

1984

The Journal of Physiology

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SUMMARY1. The actions of histamine on myenteric neurones were investigated with intracellular recording methods in guinea-pig small intestine.2. The actions of histamine at the ganglion cell soma were: membrane depolarization, increased input resistance, suppression of post-spike hyperpolarizing potentials, augmented excitability and repetitive spike discharge. Excitability was enhanced also at spike initiation sites remote from the cell body.3. Both H1 and H2 receptors were involved in the response to histamine. Dimaprit mimicked the responses to histamine in 80 % and 2-methylhistamine in 50 % of the trials. Cimetidine was an antagonist for histamine in 82 % and for dimaprit in all of the trials. Pyrilamine blocked the actions of histamine in 59 % of the cells and always blocked the action of 2-methylhistamine. 4. Histamine mimicked slow synaptic excitation in the neurones, but was ruled out as a neurotransmitter for the slow excitatory post-synaptic potential (e.p.s.p.).5. Histamine either did not affect the responses to 5-hydroxytryptamine, substance P and acetylcholine or it potentiated the responses to these putative neurotransmitters for slow synaptic excitation.6. The results support the possibility that histamine released from mast cells by circulating peptidergic messengers, by neurotransmitters or during anaphylaxis could influence enteric nervous function.

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“…In 1981, in view of rapidly emerging evidence that the ENS expressed independent neurophysiologic properties akin to the mammalian brain and spinal cord, I coined the now universally accepted term, brain-in-the-gut, in a review in the 1981 Annual Review of Physiology [27].…”

Section: Contributions To Digestive Sciencementioning

confidence: 99%

GRG Profiles: Jackie D. Wood

Wood

2016

Dig Dis Sci

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Intrinsic Neural Control of Intestinal Motility

Cited by 91 publications

References 49 publications

Effect of the acupoints ST-36 (Zusanli) and SP-6 (Sanyinjiao) on intestinal myoelectric activity of Wistar rats

Effect of the acupoints ST-36 (Zusanli) and SP-6 (Sanyinjiao) on intestinal myoelectric activity of Wistar rats

Intracellular study of effects of histamine on electrical behaviour of myenteric neurones in guinea‐pig small intestine.

GRG Profiles: Jackie D. Wood

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