Intrinsic network activity in tinnitus investigated using functional MRI

Leaver, Amber M.; Turesky, Ted K.; Seydell‐Greenwald, Anna; Morgan, Susan E.; Kim, Hung J.; Rauschecker, Josef P.

doi:10.1002/hbm.23204

Cited by 100 publications

(94 citation statements)

References 94 publications

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“…EEG study suggested that tinnitus patients differed from healthy controls by increased delta and theta activity in the parahippocampus (Moazami-Goudarzi et al, 2010). Prior resting-state fMRI studies also provided further support linking tinnitus physiopathology with parahippocampal region involved in mnemonic network (Maudoux et al, 2012a; Chen et al, 2015b; Leaver et al, 2016b). …”

Section: Discussionmentioning

confidence: 87%

“…Using our inclusion/exclusion criteria, we identified nine eligible neuroimaging studies utilizing different methods, including SPECT (Laureano et al, 2014; Ueyama et al, 2015), PET (Geven et al, 2014), and fMRI (Maudoux et al, 2012a; Chen et al, 2014, 2015d, 2016; Leaver et al, 2016b). Figure 1 is a flow diagram showing the steps in the identification, exclusion and inclusion of the studies.…”

Section: Resultsmentioning

confidence: 99%

“…A growing number of studies have used resting-state fMRI to investigate tinnitus (Husain and Schmidt, 2014) and multiple brain networks implicated in tinnitus have been identified, such as the auditory network (Burton et al, 2012; Kim et al, 2012; Maudoux et al, 2012a,b; Schmidt et al, 2013; Hinkley et al, 2015; Minami et al, 2015; Leaver et al, 2016b), default mode network (DMN; Schmidt et al, 2013; Chen et al, 2014, 2015d; Leaver et al, 2016b), dorsal attention network (DAN; Burton et al, 2012; Schmidt et al, 2013), ventral attention network (VAN; Burton et al, 2012), and visual network (Burton et al, 2012; Chen et al, 2014, 2015d). As such, tinnitus can be seen as the interaction of multiple brain subnetworks, each contributing to different aspects of tinnitus such as its acoustic features, emotional affect and awareness or attention.…”

Section: Introductionmentioning

confidence: 99%

“…However, these studies reported relatively inconsistent results. For instance, most researches demonstrated the increased resting-state brain activity between tinnitus patients and healthy controls (Maudoux et al, 2012a; Chen et al, 2014, 2016; Laureano et al, 2014; Yang et al, 2014; Ueyama et al, 2015), while others failed to identify any regions of increased brain activity (Geven et al, 2014; Leaver et al, 2016b). Moreover, several studies have failed to detect any differences in network processing between tinnitus patients and controls (Wineland et al, 2012; Davies et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

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Resting-State Brain Abnormalities in Chronic Subjective Tinnitus: A Meta-Analysis

Chen

Wang

et al. 2017

Front. Hum. Neurosci.

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Purpose: The neural mechanisms that give rise to the phantom sound of tinnitus have not been fully elucidated. Neuroimaging studies have revealed abnormalities in resting-state activity that could represent the neural signature of tinnitus, but there is considerable heterogeneity in the data. To address this issue, we conducted a meta-analysis of published neuroimaging studies aimed at identifying a common core of resting-state brain abnormalities in tinnitus patients.Methods: A systematic search was conducted for whole-brain resting-state neuroimaging studies with SPECT, PET and functional MRI that compared chronic tinnitus patients with healthy controls. The authors searched PubMed, Science Direct, Web of Knowledge and Embase databases for neuroimaging studies on tinnitus published up to September 2016. From each study, coordinates were extracted from clusters with significant differences between tinnitus subjects and controls. Meta-analysis was performed using the activation likelihood estimation (ALE) method.Results: Data were included from nine resting-state neuroimaging studies that reported a total of 51 distinct foci. The meta-analysis identified consistent regions of increased resting-state brain activity in tinnitus patients relative to controls that included, bilaterally, the insula, middle temporal gyrus (MTG), inferior frontal gyrus (IFG), parahippocampal gyrus, cerebellum posterior lobe and right superior frontal gyrus. Moreover, decreased brain activity was only observed in the left cuneus and right thalamus.Conclusions: The current meta-analysis is, to our knowledge, the first to demonstrate a characteristic pattern of resting-state brain abnormalities that may serve as neuroimaging markers and contribute to the understanding of neuropathophysiological mechanisms for chronic tinnitus.

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Section: Discussionmentioning

confidence: 87%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Resting-State Brain Abnormalities in Chronic Subjective Tinnitus: A Meta-Analysis

Chen

Wang

et al. 2017

Front. Hum. Neurosci.

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“…The intrinsic DMN activation has been shown to be reduced in patients with psychiatric disorders (Broyd et al, 2009; Sripada et al, 2012) but also in patients experiencing tinnitus-related distress (De Ridder et al, 2014; Husain and Schmidt, 2014; Lanting et al, 2016; Leaver et al, 2016). However, opposite findings with respect to recent-onset tinnitus have been observed, though focused on the precuneus, too (Carpenter-Thompson et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Heidelberg Neuro-Music Therapy Enhances Task-Negative Activity in Tinnitus Patients

Krick

Argstatter²,

Grapp³

et al. 2017

Front. Neurosci.

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Background: Suffering from tinnitus causes mental distress in most patients. Recent findings point toward a diminished activity of the brain's default-mode network (DMN) in subjects with mental disorders including depression or anxiety and also recently in subjects with tinnitus-related distress. We recently developed a therapeutic intervention, namely the Heidelberg Neuro-Music Therapy (HNMT), which shows an effective reduction of tinnitus-related distress following a 1-week short-term treatment. This approach offers the possibility to evaluate the neural changes associated with the improvements in tinnitus distress. We previously reported gray matter (GM) reorganization in DMN regions and in primary auditory areas following HNMT in cases of recent-onset tinnitus. Here we evaluate on the same patient group, using functional MRI (fMRI), the activity of the DMN following the improvements tinnitus-related distress related to the HNMT intervention.Methods: The DMN activity was estimated by the task-negative activation (TNA) during long inter-trial intervals in a word recognition task. The level of TNA was evaluated twice, before and after the 1-week study period, in 18 treated tinnitus patients (“treatment group,” TG), 21 passive tinnitus controls (PTC), and 22 active healthy controls (AC). During the study, the participants in TG and AC groups were treated with HNMT, whereas PTC patients did not receive any tinnitus-specific treatment. Therapy-related effects on DMN activity were assessed by comparing the pairs of fMRI records from the TG and PTC groups.Results: Treatment of the TG group with HNMT resulted in an augmented DMN activity in the PCC by 2.5% whereas no change was found in AC and PTC groups. This enhancement of PCC activity correlated with a reduction in tinnitus distress (Spearman Rho: −0.5; p < 0.005).Conclusion: Our findings show that an increased DMN activity, especially in the PCC, underlies the improvements in tinnitus-related distress triggered by HNMT and identify the DMN as an important network involved in therapeutic improvements.

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Risk of Tinnitus After Medial Temporal Lobe Surgery

et al. 2017

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Tinnitus is a phantom auditory percept in the absence of external acoustic stimulation. 1 Its prevalence in the United States increases with age from 5% for young adults to 14% after age 65 years. 2 Typically, tinnitus is viewed as having an exclusively auditory origin. However, recent brain imaging studies 3,4 suggest that nonauditory brain structures could be involved in the genesis of tinnitus. In this respect, Rauschecker et al 5 proposed that tinnitus might be the result of a dysfunctional neural "noise-cancellation" mechanism. They postulated that a peripheral deafferentation (eg, aging) generates a tinnitusrelated activity that is normally blocked at the level of the medial geniculate nucleus via amygdalar inhibitory projections. However, no clinical evidence has supported this hypothesis to date. To clarify the role of the medial temporal lobe (MTL) structures (eg, amygdala 5 and hippocampus 3 ) in tinnitus, we compared the prevalence of tinnitus among patients who underwent unilateral MTL resection encroaching on the amygdala with that among matched controls and participants with self-reported epilepsy (SRE) but no surgery. The surgical cases were expected to have increased difficulty in inhibiting the tinnitus signal and therefore a higher prevalence of tinnitus.Methods | This study received approval from the institutional review board of the Ile-de-France VI Ethics Committee. The committee stated that no written or oral informed consent was required from patients.Cases. Using medical records from July 15, 1991, through October 31, 2014, we mailed a letter announcing our survey to 247 consecutive surgical patients who had undergone unilateral MTL resection encroaching on the amygdala for the relief of medically intractable epilepsy. Among the 213 patients with a valid address, 166 (77.9%) responded to our health questionnaire.

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Intrinsic network activity in tinnitus investigated using functional MRI

Cited by 100 publications

References 94 publications

Resting-State Brain Abnormalities in Chronic Subjective Tinnitus: A Meta-Analysis

Resting-State Brain Abnormalities in Chronic Subjective Tinnitus: A Meta-Analysis

Heidelberg Neuro-Music Therapy Enhances Task-Negative Activity in Tinnitus Patients

Risk of Tinnitus After Medial Temporal Lobe Surgery

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