“…The above data is supported by analysis of gene expression profiles of renal transplants, which revealed reduced FBP-1,6 mRNA level in graft with IF/TA (Scherer et al, 2003). Determination of urinary FBP-1,6 activity was not only used for evaluation of transplanted kidneys, but also to estimate the degree of damage to renal tubules of diabetic patients (Eid et al, 2006), in idiopatic nephrotic syndrome (Kępka et al, 2008) acute pyelonephritis (ZochZwierz et al, 2004), heavy metal (e.g.HgCl 2 ) or, maleic acid intoxication (Kotanko et al, 1984), after trichloroethylene (TCE) administration (Khan et al, 2009). The urinary FBP-1,6 activity significantly increases after nephrotoxic drugs (ifosfamide, cisplatinum) (Pfaller et al, 1994) prednisolone, and azathioprine (Kotanko et al, 1986), cyclosporine, sirolimus and tacrolimus (Klawitter et al,2010).…”