“Intrinsic Gene Expression” subtypes correlated with grade and morphometric parameters reveal a high proportion of aggressive basal-like tumors among black women of African ancestry

Olopade, O. I.; Ikpatt, Francis; Dignam, James J.; Khramtsov, Andrey; Tetriakova, M.; Grushko, Tatyana A.; Fackenthal, Jim; Nanda, Rita; Ndoma-Egba, R.; Perou, Charles M.

doi:10.1200/jco.2004.22.90140.9509

Cited by 13 publications

(5 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A high frequency of basal-like tumors was observed in a study of breast cancer in Nigerian women, among whom ER-negative and HER2-nega-tive tumors comprised 87 of 148 women, or 59% of total cases. 47 According to gene expression studies, ER-negative breast tumors fall into 1 of 2 categories, 14,15 namely basal-like tumors (ER−, PR−, and HER−) and the HER2ϩ/ER− subtype (HER2ϩ/ER−) (Figure 1). The HER2ϩ/ ER-group, which is also a high-grade and ER-negative tumor group, did not vary significantly with age or race.…”

Section: Commentmentioning

confidence: 99%

Race, Breast Cancer Subtypes, and Survival in the Carolina Breast Cancer Study

Carey¹,

Perou²,

Livasy³

et al. 2006

JAMA

3,319

274

3,067

View full text Add to dashboard Cite

show abstract

Section: Commentmentioning

confidence: 99%

Race, Breast Cancer Subtypes, and Survival in the Carolina Breast Cancer Study

Carey¹,

Perou²,

Livasy³

et al. 2006

JAMA

3,319

274

3,067

View full text Add to dashboard Cite

show abstract

“…Similarly, in a population‐based study of women in Atlanta who were aged <55 years at the time of diagnosis between 1990 and 1992, Lund et al determined that TNTs were more prevalent among AA women compared with white women (46.6% vs 21.7%; P < .001), again after adjustment for age and stage of disease (OR of 2.1) 17. Finally, in a study of breast cancer diagnosed among Nigerian women, 59% of cases were ER‐negative and HER‐2 negative 28. Prior studies, including work by us, did not observe these racial differences among the HER‐2+‐expressing group.…”

Section: Discussionmentioning

confidence: 99%

“…Several factors have very recently been postulated to be associated with the induction of TNTs, including primitive stem cell origins,29–31 genetic variations,20, 32, 33 environmental and/or various behavioral components,22–34 and, ultimately, gene and environmental/behavior interactions. However, to our knowledge, reasons for the early‐onset age of TNT, and particularly among AA women, have not been rigorously investigated to date and remain unresolved.…”

Section: Discussionmentioning

confidence: 99%

Differential adsorption of heavy metal ions by cotton stalk cation‐exchangers containing multiple functional groups

Nada

El-Wakil

Hassan

et al. 2006

J of Applied Polymer Sci

View full text Add to dashboard Cite

Esterification of cotton stalks with chlorosulfonic acid, phosphorus oxychloride, and their mixture was carried out with the aim to prepare cation exchangers for the removal of heavy metal ions from industrial waste water. Elemental analysis, Fourier transform infrared (FTIR) analysis, and sodium ions binding capacity were used to prove the occurrence of the esterification. The efficiency of the prepared cation exchangers to remove some heavy metal ions (strontium, arsenic, copper, and nickel) at different metal ion concentration, pH, contact time, and temperature was studied. The results showed that cotton stalks that contain both phosphate and sulfonate groups (phosphosulfonated cotton stalks) showed higher adsorption of the different heavy metal ions than cotton stalks containing sulfonate or phosphate on a separate basis.

show abstract

“…Most BRCA1 ‐related breast cancer, but only 15% of sporadic breast cancer in Caucasian women, appears to have the basal phenotype. However, several studies suggest that breast cancer in women of African ancestry may have a higher proportion of this subclass ([36–38] and reviewed in [39]). A high frequency of basal‐like tumors was observed in a Nigerian study, where 87 of 148 (59%) breast cancer cases were both ER‐ and HER2‐ (36).…”

Section: Biology – the Tumormentioning

confidence: 99%

Breast Cancer: A Neglected Disease for the Majority of Affected Women Worldwide

Ginsburg¹,

Love²

2011

The Breast Journal

View full text Add to dashboard Cite

Recent progress with declines in mortality in some high income countries has obscured the fact that for the majority of women worldwide who are newly diagnosed, breast cancer is a neglected disease in the context of other numerically more frequent health problems. For this growing majority, it is also an orphan disease, in that detailed knowledge about tumor characteristics and relevant host biology necessary to provide even basic care are absent. With the possible exception of nutritional recommendations, current international cancer policy and planning initiatives are irrelevant to breast cancer. The progress that has occurred in high income countries has come at extraordinary fiscal expense and patient toxicity, which of themselves suggest non-relevance to women and health care practitioners in middle and low income countries. The implications of these circumstances seem clear: if the promise of the now 60 year-old Declaration of Human Rights, that the fruits of medical science accrue to all mankind, is to be realized with respect to breast cancer, a basic and translational global research initiative should be launched.

show abstract

“Intrinsic Gene Expression” subtypes correlated with grade and morphometric parameters reveal a high proportion of aggressive basal-like tumors among black women of African ancestry

Cited by 13 publications

References 0 publications

Race, Breast Cancer Subtypes, and Survival in the Carolina Breast Cancer Study

Race, Breast Cancer Subtypes, and Survival in the Carolina Breast Cancer Study

Differential adsorption of heavy metal ions by cotton stalk cation‐exchangers containing multiple functional groups

Breast Cancer: A Neglected Disease for the Majority of Affected Women Worldwide

Contact Info

Product

Resources

About