Intrinsic factors affecting adequacy of thyroid nodule fine‐needle aspiration cytology

Grani, Giorgio; Calvanese, A.; Carbotta, Giovanni; D’Alessandri, M.; Nesca, Angela; Bianchini, Marta; Sordo, Marianna Del; Fumarola, Angela

doi:10.1111/j.1365-2265.2012.04507.x

Cited by 45 publications

(45 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These results are consistent with those of a previous study investigating radiologist-performed US-FNAC. 16 Interestingly, tumors located in the left neck were more associated with inadequate sampling in our study, although the statistical significance was not verified (p = 0.060). This finding may be related to the surgeon's position and handedness.…”

Section: Discussioncontrasting

confidence: 72%

Surgeon-Performed Ultrasound-Guided Fine-Needle Aspiration Cytology of Head and Neck Mass Lesions: Sampling Adequacy and Diagnostic Accuracy

et al. 2014

View full text Add to dashboard Cite

show abstract

Section: Discussioncontrasting

confidence: 72%

Surgeon-Performed Ultrasound-Guided Fine-Needle Aspiration Cytology of Head and Neck Mass Lesions: Sampling Adequacy and Diagnostic Accuracy

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Other studies confirm what we experience in daily practice: blood contamination is one of the main qualitative reasons for nondiagnostic thyroid cytology, and FNA of a hypervascular nodule will often result in bloody aspirates [4,19]. Strong intranodular vascularization is rarely mentioned in the literature as a predictor of nondiagnostic cytology [31]. It is, however, described as a possible predictor of malignancy, emphasizing the need for adequate cytology [7,12,32].…”

Section: Discussionmentioning

confidence: 51%

Thyroid Ultrasound-Guided Fine-Needle Aspiration: The Positive Influence of On-Site Adequacy Assessment and Number of Needle Passes on Diagnostic Cytology Rate

et al. 2016

View full text Add to dashboard Cite

Objective: Nondiagnostic cytology is the most important limitation of thyroid ultrasound-guided fine-needle aspiration (US-FNA). This study aimed to identify factors associated with the adequacy rate of thyroid US-FNA. Study Design: Consecutive thyroid US-FNAs (2006-2013) were retrospectively included. Attending radiologists, radiology fellows and radiology residents performed US-FNA, usually involving 2-3 needle passes. In more recent years, rapid on-site adequacy assessment (ROSAA) was performed to ensure specimen adequacy. US characteristics, procedural variations and cytology results were extracted from US and pathology reports and statistically evaluated. Results: Diagnostic cytology was obtained in 64.6% of 1,381 thyroid US-FNAs. Factors associated with nondiagnostic cytology were ROSAA (74.6% diagnostic cytology, OR 0.55, 95% CI 0.42-0.71), ≥3 clinic visits for US-FNA of the same thyroid nodule (54.7%, OR 1.56, 95% CI 1.16-2.10) and increased intranodular vascularization (51.8%, OR 1.73, 95% CI 1.17-2.57). With ROSAA, an increasing number of needle passes demonstrated improving adequacy rates. The adequacy rate was not operator-dependent. Conclusion: This study demonstrates that ROSAA improves the adequacy rate of thyroid US-FNA. Without ROSAA, we recommend performing at least 3 needle passes. Less diagnostic cytology is obtained from nodules with increased intranodular vascularization or from those undergoing US-FNA ≥3 times.

show abstract

“…This led to the high proportion of malignancy and suspicious of malignancy (20.3%) compared with other reports (Cavaliere et al, 2009). It has been reported that thyroid nodules with a diameter <10 mm were more frequently non-diagnostic (Grani et al, 2013). In view of this, the number of non-diagnostic nodules in our study (20.9%) was receivable.…”

Section: Discussioncontrasting

confidence: 44%

“…Many scholars have focused on the valuable role of US features as predictors of malignancy (Iannuccilli et al, 2004;Kang et al, 2004;Kim et al, 2008;Lee et al, 2011;Vinayak et al, 2012;Kim et al, 2013a;Kim et al, 2013b). Currently, there is no internationally acknowledged guideline of selecting which thyroid nodules for biopsy, especially for the subcentimeter-sized ones (Iannuccilli et al, 2004;Grani et al, 2013;Kim et al, 2013a;Nixon et al, 2013). Many institutions now apply ultrasound-guided FNAB just on nodules larger than 1 cm in diameter.…”

Section: Discussionmentioning

confidence: 99%

Ultrasound Score to Select Subcentimeter-sized Thyroid Nodules Requiring Ultrasound-guided Fine Needle Aspiration Biopsy in Eastern China

Cheng

Chen²,

Zheng³

et al. 2013

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

Ultrasound-guided fine needle aspiration biopsy (FNAB) is a costly diagnostic item with a low yield in identifying the tiny proportion of nodules that actually represent malignant disease. Our aim through this study was to obtain an ultrasound (US) score for selecting subcentimeter-sized thyroid nodules requiring FNAB in eastern China. Some 248 patients for a total of 270 thyroid nodules less than 1 cm in diameter underwent FNAB and subsequent surgery from January 2006 to March 2012 at our hospital. The clinicopathological and US data from all the nodules were analyzed retrospectively. An US score was developed on the basis of independent predictive factors for malignancy. Irregular shape, hypoechogenicity, no well-defined margin, presence of calcifications and ratio between antero-posterior and transversal diameters (AP/TR) ≥1 were independent predictive factors for malignancy on logistic regression analysis. US score were statistically significant, with ≤2 favoring benignancy with an 80.3% sensitivity and a 72.7% specificity. US score is useful for differentiating between malignant and benign subcentimeter-sized thyroid nodules. We suggest FNAB for nodules when the US score is higher than 2.

show abstract

Intrinsic factors affecting adequacy of thyroid nodule fine‐needle aspiration cytology

Abstract: Some ultrasonographic features suggestive of malignancy may be predictive of inadequate cytology. Patients must be notified that the FNA report may be nondiagnostic and that this represents a limitation of the technique related to the structure of lesions.

Cited by 45 publications

References 12 publications

Surgeon-Performed Ultrasound-Guided Fine-Needle Aspiration Cytology of Head and Neck Mass Lesions: Sampling Adequacy and Diagnostic Accuracy

Surgeon-Performed Ultrasound-Guided Fine-Needle Aspiration Cytology of Head and Neck Mass Lesions: Sampling Adequacy and Diagnostic Accuracy

Thyroid Ultrasound-Guided Fine-Needle Aspiration: The Positive Influence of On-Site Adequacy Assessment and Number of Needle Passes on Diagnostic Cytology Rate

Ultrasound Score to Select Subcentimeter-sized Thyroid Nodules Requiring Ultrasound-guided Fine Needle Aspiration Biopsy in Eastern China

Contact Info

Product

Resources

About