Intrinsic circadian timekeeping properties of the thalamic lateral geniculate nucleus

Chrobok, Łukasz; Pradel, Kamil; Janik, Marcelina; Sanetra, Anna Magdalena; Bubka, Monika; Myung, Jihwan; Rahim, Amalia Ridla; Klich, Jasmin Daniela; Jeczmien-Lazur, Jagoda Stanislawa; Palus-Chramiec, Katarzyna; Lewandowski, M.H.

doi:10.1002/jnr.24973

Cited by 10 publications

(7 citation statements)

References 80 publications

(117 reference statements)

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“…Though the pallidum is predominantly considered a motor region, a recent study reported that pallidal oscillations in local field potentials predicted sleep stages in patients with movement disorders providing evidence of its role in sleep 49 . Associations with thalamic GMV were not surprising since the thalamus is a key region for both sleep homeostatic and circadian time keeping 50,51 . Reduced volumes in the striatum have been linked to enhanced reward sensitivity, deficits in inhibitory control 52 and greater risk-taking 53 .…”

Section: Discussionmentioning

confidence: 99%

Changes in rest-activity rhythms in adolescents as they age: associations with brain changes and behavior in the ABCD study

Zhang,

Schwandt,

Vines

et al. 2024

Preprint

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BackgroundAdolescents with disrupted rest-activity rhythm (RAR) including shorter sleep duration, later sleep timing and low physical activity levels have higher risk for mental and behavioral problems. However, it remains unclear whether the same associations can be observed for within-subject changes in RAR.MethodsOur longitudinal investigation on RAR used Fitbit data from the Adolescent Brain Cognitive Development (ABCD) Study at the 2-year (FL2: aged 10-13 years) and 4-year follow-up (FL4: aged 13-16 years). 963 youths had good-quality Fitbit data at both time points. In this study we examined changes in RAR from FL2 to FL4, their environmental and demographic contributors as well as brain and behavioral correlates.ResultsFrom FL2 to FL4, adolescents showed decreases in sleep duration and physical activity as well as delayed sleep timing (Cohen’s d .44-.75). The contributions of environmental and demographic factors to RAR changes were greatest to sleep timing (explained 10% variance) and least to sleep duration (explained 1% variance). Delays in sleep timing had stronger correlations with behavioral problems including greater impulsivity and poor academic performance than reductions in sleep duration or physical activity. Additionally, the various brain measures differed in their sensitivity to RAR changes. Reductions in sleep duration were associated with decreased functional connectivity between subcortical regions and sensorimotor and cingulo-opercular networks and with enhanced functional connectivity between sensorimotor, visual and auditory networks. Delays in sleep timing were mainly associated with grey matter changes in subcortical regions while reduced physical activity level was mostly associated with decreased integrity of white matter fiber tracts.ConclusionsThe current findings corroborate the role of sleep and physical activity in adolescent’s brain neurodevelopment and behavior problems. RAR might serve as biomarkers or treatment targets for monitoring or treating mental and behavioral problems in adolescents.

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Section: Discussionmentioning

confidence: 99%

Changes in rest-activity rhythms in adolescents as they age: associations with brain changes and behavior in the ABCD study

Zhang,

Schwandt,

Vines

et al. 2024

Preprint

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“…In 2020, Berglund et al incorporated channelrhodopsin-2 with step-function mutations as the light-sensing opsin moiety and sbGluc as the light-emitting luciferase in a new luminopsin fusion protein, named step-function luminopsin (SFLMO), which has diversified the toolbox of bioluminescence optogenetic probes for bimodal control of neuromodulation for functional interrogation or therapeutic purposes [ 64 ]. Furthermore, scientists have also employed both the optogenetics approach and bioluminescence reporters to investigate mammalian circadian rhythms [ 89 , 90 , 91 ].…”

Section: Bioluminescence-induced Photoswitchable Protein-based Optica...mentioning

confidence: 99%

Coelenterazine-Type Bioluminescence-Induced Optical Probes for Sensing and Controlling Biological Processes

Jiang

Song

Zhang

2023

IJMS

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Bioluminescence-based probes have long been used to quantify and visualize biological processes in vitro and in vivo. Over the past years, we have witnessed the trend of bioluminescence-driven optogenetic systems. Typically, bioluminescence emitted from coelenterazine-type luciferin–luciferase reactions activate light-sensitive proteins, which induce downstream events. The development of coelenterazine-type bioluminescence-induced photosensory domain-based probes has been applied in the imaging, sensing, and control of cellular activities, signaling pathways, and synthetic genetic circuits in vitro and in vivo. This strategy can not only shed light on the mechanisms of diseases, but also promote interrelated therapy development. Here, this review provides an overview of these optical probes for sensing and controlling biological processes, highlights their applications and optimizations, and discusses the possible future directions.

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“…However, evidence accumulating over the last 2 decades questions the supremacy of the SCN ( Yoo et al, 2004 ; Guilding and Piggins, 2007 ; Paul et al, 2020 ). With the discovery of intrinsic clock gene expression in several extra-SCN brain nuclei, from the olfactory bulb ( Abraham, 2005 ), through thalamic ( Chrobok et al, 2021a ), epithalamic ( Guilding et al, 2010 ), hypothalamic ( Guilding et al, 2009 ) and midbrain regions ( Chrobok et al, 2021b ), all the way to the hindbrain ( Kaneko et al, 2009 ; Chrobok et al, 2020 ), it is now believed that at least a part of the rhythmic control of homeostasis must be devolved to such local clocks. These circadian timekeeping centres vary in the degree of their autonomy ( Guilding and Piggins, 2007 ; Paul et al, 2020 ; Chrobok et al, 2021c ).…”

Section: Introductionmentioning

confidence: 99%

Racing and Pacing in the Reward System: A Multi-Clock Circadian Control Over Dopaminergic Signalling

et al. 2022

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Level of motivation, responsiveness to rewards and punishment, invigoration of exploratory behaviours, and motor performance are subject to daily fluctuations that emerge from circadian rhythms in neuronal activity of the midbrain’s dopaminergic system. While endogenous circadian rhythms are weak in the ventral tegmental area and substantia nigra pars compacta, daily changes in expression of core clock genes, ion channels, neurotransmitter receptors, dopamine-synthesising enzymes, and dopamine transporters, accompanied by changes in electrical activity, are readily observed in these nuclei. These processes cause dopamine levels released in structures innervated by midbrain dopaminergic neurons (e.g., the striatum) to oscillate in a circadian fashion. Additionally, growing evidence show that the master circadian clock located in the suprachiasmatic nucleus of the hypothalamus (SCN) rhythmically influences the activity of the dopaminergic system through various intermediate targets. Thus, circadian changes in the activity of the dopaminergic system and concomitant dopamine release observed on a daily scale are likely to be generated both intrinsically and entrained by the master clock. Previous studies have shown that the information about the value and salience of stimuli perceived by the animal is encoded in the neuronal activity of brain structures innervating midbrain dopaminergic centres. Some of these structures themselves are relatively autonomous oscillators, while others exhibit a weak endogenous circadian rhythm synchronised by the SCN. Here, we place the dopaminergic system as a hub in the extensive network of extra-SCN circadian oscillators and discuss the possible consequences of its daily entrainment for animal physiology and behaviour.

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Intrinsic circadian timekeeping properties of the thalamic lateral geniculate nucleus

Cited by 10 publications

References 80 publications

Changes in rest-activity rhythms in adolescents as they age: associations with brain changes and behavior in the ABCD study

Changes in rest-activity rhythms in adolescents as they age: associations with brain changes and behavior in the ABCD study

Coelenterazine-Type Bioluminescence-Induced Optical Probes for Sensing and Controlling Biological Processes

Racing and Pacing in the Reward System: A Multi-Clock Circadian Control Over Dopaminergic Signalling

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