Intrinsic characteristics of contact and respiratory allergens influence production of polarizing cytokines by dendritic cells

Toebak, M.J.; Moed, H. D.; Blomberg, Maureen; Bruynzeel, Derk P.; Gibbs, Susan; Scheper, Rik J.; Rustemeyer, Thomas

doi:10.1111/j.1600-0536.2006.00918.x

Cited by 34 publications

(20 citation statements)

References 33 publications

(38 reference statements)

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“…It is argued also that skin and respiratory chemical allergens induce distinct cytokine secretion patterns (Th1-and Th2-type, respectively), and that this may provide a basis for distinguishing between these allergens in the context of hazard characterisation (Kimber and Dearman, 1997a;Dearman and Kimber, 2001;Dearman et al, 2002;Plitnick et al, 2002;Selgrade et al, 2006;De Jong et al, 2009;Kimber et al, 2011;Adenuga et al, 2012). Although evidence for the differential immunological selectivity of contact and respiratory chemical allergens has been based largely on studies in experimental animals, there is emerging evidence that the same, or at least similar, patterns are seen in humans (Toebak et al, 2006;Kimber et al, 2013;Newell et al, 2013;Ouyang et al, 2013).…”

Section: Mechanisms Through Which Sensitisation Of the Respiratory Trmentioning

confidence: 88%

Thresholds in chemical respiratory sensitisation

et al. 2015

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There is a continuing interest in determining whether it is possible to identify thresholds for chemical allergy. Here allergic sensitisation of the respiratory tract by chemicals is considered in this context. This is an important occupational health problem, being associated with rhinitis and asthma, and in addition provides toxicologists and risk assessors with a number of challenges. In common with all forms of allergic disease chemical respiratory allergy develops in two phases. In the first (induction) phase exposure to a chemical allergen (by an appropriate route of exposure) causes immunological priming and sensitisation of the respiratory tract. The second (elicitation) phase is triggered if a sensitised subject is exposed subsequently to the same chemical allergen via inhalation. A secondary immune response will be provoked in the respiratory tract resulting in inflammation and the signs and symptoms of a respiratory hypersensitivity reaction. In this article attention has focused on the identification of threshold values during the acquisition of sensitisation. Current mechanistic understanding of allergy is such that it can be assumed that the development of sensitisation (and also the elicitation of an allergic reaction) is a threshold phenomenon; there will be levels of exposure below which sensitisation will not be acquired. That is, all immune responses, including allergic sensitisation, have threshold requirement for the availability of antigen/allergen, below which a response will fail to develop. The issue addressed here is whether there are methods available or clinical/epidemiological data that permit the identification of such thresholds. This document reviews briefly relevant human studies of occupational asthma, and experimental models that have been developed (or are being developed) for the identification and characterisation of chemical respiratory allergens. The main conclusion drawn is that although there is evidence that the acquisition of sensitisation to chemical respiratory allergens is a dose-related phenomenon, and that thresholds exist, it is frequently difficult to define accurate numerical values for threshold exposure levels. Nevertheless, based on occupational exposure data it may sometimes be possible to derive levels of exposure in the workplace, which are safe. An additional observation is the lack currently of suitable experimental methods for both routine hazard characterisation and the measurement of thresholds, and that such methods are still some way off. Given the current trajectory of toxicology, and the move towards the use of non-animal in vitro and/or in silico) methods, there is a need to consider the development of alternative approaches for the identification and characterisation of respiratory sensitisation hazards, and for risk assessment.

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Section: Mechanisms Through Which Sensitisation Of the Respiratory Trmentioning

confidence: 88%

Thresholds in chemical respiratory sensitisation

et al. 2015

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“…RANTES has been previously identified in vivo as being a key cytokine in the murine ear test to DNCB (Baumer et al, 2004) thus supporting its relevance as an in vitro biomarker. In order to compare the sensitizer predictability of RANTES with a currently used cytokine (Mitjans et al, 2008, Toebak et al, 2006, Miyazawa et al, 2008 we investigated the generation of IL-8 on MUTZ-3 cells. Our unpublished data showed that IL-8 was increased comparably to the sensitizers seen for RANTES, thus, RANTES can be considered as extending the in vitro biomarkers available for sensitizer testing.…”

Section: Discussionmentioning

confidence: 99%

“…Researchers have identified a number of cytokines of importance in the sensitization process which may constitute an important aspect of in vitro test development. Recent studies suggested that IL-8 detection following sensitizer or nonsensitizer application to THP-1 cells could function as a promising in vitro model to assist with sensitization screening (Mitjans et al, 2008, Miyazawa et al, 2008, Toebak et al, 2006.…”

Section: Introductionmentioning

confidence: 99%

Identification of PDL-1 as a novel biomarker of sensitizer exposure in dendritic-like cells

Williams¹,

Williams²,

McLeod³

2010

Toxicology in Vitro

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We recommend you cite the published version. The publisher's URL is http://dx.doi.org/10.1016/j.tiv.2010.05.008Refereed: Yes (no note) Disclaimer UWE has obtained warranties from all depositors as to their title in the material deposited and as to their right to deposit such material. UWE makes no representation or warranties of commercial utility, title, or fitness for a particular purpose or any other warranty, express or implied in respect of any material deposited.UWE makes no representation that the use of the materials will not infringe any patent, copyright, trademark or other property or proprietary rights. UWE accepts no liability for any infringement of intellectual property rights in any material deposited but will remove such material from public view pending investigation in the event of an allegation of any such infringement. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. PLEASE SCROLL DOWN FOR TEXT. Accepted Manuscript ACCEPTED MANUSCRIPT ACCEPTED MANUSCRIPT Abstract.The and Cin. Our findings highlight novel biomarkers which, in MUTZ-3 cells, could be taken forward within a multiple biomarker in vitro assay ensuring strong and reliable predictability.

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“…This hapten increases the expression of DC surface markers essential for antigen presentation, such as the molecules of the major histocompatibility complex class II and costimulatory molecules (4)(5)(6)(7)(8)(9)(10) and increases chemokine production and chemokine receptor expression (11)(12)(13)(14) , thereby favoring antigen presentation. In DC, contact sensitizers activate mitogen-activated protein kinases (15)(16)(17)(18)(19)(20)(21) .…”

Section: Introductionmentioning

confidence: 99%