2021
DOI: 10.1038/s41537-021-00193-w
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Intrinsic cerebellar functional connectivity of social cognition and theory of mind in first-episode psychosis patients

Abstract: Neuroimaging studies have revealed how intrinsic dysconnectivity among cortical regions of the mentalizing network (MENT) and the mirror neuron system (MNS) could explain the theory of mind (ToM) deficit in schizophrenia patients. However, despite the concurrent involvement of the cerebellum with the cortex in social cognition, the dysfunction in intrinsic interplay between the cerebellar nodes of MENT/MNS and the cortex in schizophrenia patients remains unknown. Thus, we aimed to investigate whether resting-s… Show more

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Cited by 11 publications
(8 citation statements)
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“…Interestingly, while we observed a widespread reduction in functional connectivity within the left dentato-thalamo-cortical loop in the immediate postoperative images, the subcortical functional connectivity between the left striatum and left GPi as well as the left GPi and left t(VA) increased, indicating probable "pathological functional hyperconnectivity. " Although the observed disruption of the cortico-striato-pallido-thalamo-cortical loop may result in subcortical functional hyperconnectivity and may appear to be unexpected, this effect has been previously described in several neurological disorders, such as traumatic brain injury (Amir et al, 2021), multiple sclerosis (Hawellek et al, 2011), cerebrovascular accidents (Nicolo et al, 2015), epilepsy (O'Muircheartaigh et al, 2012), and Parkinson's disease (Gorges et al, 2015) as well as in psychiatric disorders such as schizophrenia (Park et al, 2021) and bipolar disorder (Guo et al, 2021).…”
Section: Discussionmentioning
confidence: 83%
“…Interestingly, while we observed a widespread reduction in functional connectivity within the left dentato-thalamo-cortical loop in the immediate postoperative images, the subcortical functional connectivity between the left striatum and left GPi as well as the left GPi and left t(VA) increased, indicating probable "pathological functional hyperconnectivity. " Although the observed disruption of the cortico-striato-pallido-thalamo-cortical loop may result in subcortical functional hyperconnectivity and may appear to be unexpected, this effect has been previously described in several neurological disorders, such as traumatic brain injury (Amir et al, 2021), multiple sclerosis (Hawellek et al, 2011), cerebrovascular accidents (Nicolo et al, 2015), epilepsy (O'Muircheartaigh et al, 2012), and Parkinson's disease (Gorges et al, 2015) as well as in psychiatric disorders such as schizophrenia (Park et al, 2021) and bipolar disorder (Guo et al, 2021).…”
Section: Discussionmentioning
confidence: 83%
“…We included 29 studies ( 73 103 ) with 1,542 participants for the primary outcome and 3 studies ( 104 106 ) with 126 participants for the secondary outcome. Overall, 32 studies were included in this systematic review.…”
Section: Resultsmentioning
confidence: 99%
“…However, lesioning other salience regions revealed a negative association of the right anterior insula and left supramarginal gyrus with CU traits. Where the right anterior insula is involved in attention (Eckert et al, 2009) involving interoceptive awareness (Craig, 2009, 2011) that aids both emotion and cognitive functioning (Touroutoglou et al, 2012), the left supramarginal gyrus is primarily involved in phonological processing (Celsis et al, 1999), though hypoactivity of this region has been associated with social cognition impairments in autism (Hadjikhani et al, 2006) and early psychosis (Park et al, 2021). The negative impact on the functional connectome after removing these nodes may indicate an overreliance on these regions for similar processes that would be distributed across the amygdala and other cortical midline structures, leading to decreased whole-brain global efficiency.…”
Section: Discussionmentioning
confidence: 99%