Intrinsic Cellular Defenses (TRIMS) in Modulating Viral Infection and Immunity

Garcı́a-Sastre, Adolfo; Miorin, Lisa

doi:10.1016/b978-0-12-374279-7.14004-4

Cited by 2 publications

(2 citation statements)

References 108 publications

(136 reference statements)

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“…Type I interferon induction is a central event of the immune response against viral infection, relying on the recognition of pathogens by cellular pattern recognition receptors (PRRs), which then trigger several signaling cascades resulting in pro-inflammatory cytokines and interferon production 60 . TRIM proteins are essential and act as restriction factors or by modulating PRR signaling.…”

Section: Discussionmentioning

confidence: 99%

Annelid genomes: Enchytraeus crypticus, a soil model for the innate (and primed) immune system

et al. 2021

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Enchytraeids (Annelida) are soil invertebrates with worldwide distribution that have served as ecotoxicology models for over 20 years. We present the first high-quality reference genome of Enchytraeus crypticus, assembled from a combination of Pacific Bioscience single-molecule real-time and Illumina sequencing platforms as a 525.2 Mbp genome (910 gapless scaffolds and 18,452 genes). We highlight isopenicillin, acquired by horizontal gene transfer and conferring antibiotic function. Significant gene family expansions associated with regeneration (long interspersed nuclear elements), the innate immune system (tripartite motif-containing protein) and response to stress (cytochrome P450) were identified. The ACE (Angiotensin-converting enzyme) — a homolog of ACE2, which is involved in the coronavirus SARS-CoV-2 cell entry — is also present in E. crypticus. There is an obvious potential of using E. crypticus as a model to study interactions between regeneration, the innate immune system and aging-dependent decline.

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Section: Discussionmentioning

confidence: 99%

Annelid genomes: Enchytraeus crypticus, a soil model for the innate (and primed) immune system

et al. 2021

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show abstract

“…The recognition of pathogens by pattern recognition receptors (PRRs) triggers type I interferons (a central event of the immune response against viral infection) and signalling pro-inflammatory cytokines cascades ( García-Sastre and Miorin, 2016 ). TRIM proteins, expanded in E. crypticus ( Amorim et al, 2021 ), are essential and act as restriction factors or by modulating PRR signalling.…”

Section: Discussionmentioning

confidence: 99%