Intrinsic brain connectivity after partial sleep deprivation in young and older adults: results from the Stockholm Sleepy Brain study

Nilsonne, Gustav; Tamm, Sandra; Schwarz, Johanna; Almeida, Rita; Fischer, Håkan; Kecklund, Göran; Lekander, Mats; Fransson, Peter; Åkerstedt, Torbjörn

doi:10.1038/s41598-017-09744-7

Cited by 50 publications

(36 citation statements)

References 79 publications

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“…A more detailed report of the polysomnography results can be found in (35). Because the drop-outs in this publication differ compared to previous publications from the same experiment the numbers are slightly different compared to (28,34–36).…”

Section: Resultsmentioning

confidence: 76%

Sleep restriction caused impaired emotional regulation without detectable brain activation changes – a functional magnetic resonance imaging study

Tamm

Nilsonne

Schwarz

et al. 2018

Preprint

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Summary Sleep restriction has been proposed to cause impaired emotional processing and emotional regulation by inhibiting top-down control from prefrontal cortex to amygdala. Intentional emotional regulation after sleep restriction has however never been studied using brain imaging. We here aimed to investigate the effect of sleep restriction on emotional regulation through cognitive reappraisal. Forty-seven young (age 20-30) and 33 older (age 65-75) participants (38/23 with complete data and successful sleep intervention) performed a cognitive reappraisal task during fMRI after a night of normal sleep and after restricted sleep (3h). Emotional downregulation was associated with significantly increased activity in dorsolateral prefrontal cortex (pFWE < 0.05) and lateral orbital cortex (pFWE < 0.05) in young, but not in older subjects. Sleep restriction was associated with a decrease in self-reported regulation success to negative stimuli (p < 0.01) and a trend towards perceiving all stimuli as less negative (p = 0.07), in young participants. No effects of sleep restriction on brain activity nor connectivity were found in either age group. In conclusion, our data do not support the idea of a prefrontal-amygdala disconnect after sleep restriction, and neural mechanisms underlying behavioural effects on emotional regulation after insufficient sleep require further investigation.

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Section: Resultsmentioning

confidence: 76%

Sleep restriction caused impaired emotional regulation without detectable brain activation changes – a functional magnetic resonance imaging study

Tamm

Nilsonne

Schwarz

et al. 2018

Preprint

Self Cite

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“…As GS has previously been related to vigilance (Wong et al 2013), we analysed this variable to assess its independent contribution to this outcome variable. As expected, GS was significantly lower in RW than SD (t 29 = 5.86, p < 10 -6 ) (Yeo et al 2015, Nilsonne et al 2017. To further interrogate the relationship between GS and vigilance directly, we performed correlation analysis between changes in GS (ΔGS) and the two PVT measures.…”

Section: Changes In Global Signalmentioning

confidence: 85%

Cognitive vulnerability to sleep deprivation is robustly associated with two dynamic connectivity states

Teng

Ong

Patanaik

et al. 2019

Preprint

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Running title: Vulnerability to sleep deprivation is associated with connectivity statesThe authors of this manuscript have no financial conflicts of interest to disclose. AbstractRobustly linking dynamic functional connectivity (DFC) states to behaviour is an important goal of the fledgling research using these methods. Here, we demonstrate in an independent dataset that two connectivity states previously linked to arousal and sustained attention are associated with individual differences in vulnerability to sleep deprivation. 32 healthy participants underwent two sets of resting-state functional magnetic resonance imaging (fMRI) scans, once in a well-rested state and once after a single night of total sleep deprivation. Individual differences in vulnerability to this manipulation were measured using changes in Psychomotor Vigilance Test (PVT) performance. DFC and clustering analysis on the resting state fMRI data revealed five centroids that were highly correlated with those found in previous work, including two states associated with high and low arousal. Changes in these arousal states from the well-rested to the sleep-deprived condition specifically were correlated with changes in PVT performance. Global signal was also correlated with this change in univariate analysis, but was not a significant incremental predictor in a multivariate model. Although head motion increased following sleep deprivation, this did not predict change in PVT performance. Our results provide good evidence of the reliability, validity, and reproducibility of DFC measures, particularly with regard to measuring arousal and attention.

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“…In animal models, sleep deprivation was shown to heighten the propensity to seizures (McDermott et al, 2003 ). Sleep deprivation has been correlated with decline in various aspects of brain functional connectivity (Nilsonne et al, 2017 ). Generally, sleep deprivation is secondary to other factors such as illness, emotional or psychological stress, and alcohol use.…”

Section: Introductionmentioning

confidence: 99%

Sleep Related Epilepsy and Pharmacotherapy: An Insight

et al. 2018

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In the last several decades, sleep-related epilepsy has drawn considerable attention among epileptologists and neuroscientists in the interest of new paradigms of the disease etiology, pathogenesis and management. Sleep-related epilepsy is nocturnal seizures that manifest solely during the sleep state. Sleep comprises two distinct stages i.e., non-rapid eye movement (NREM) and rapid eye movement (REM) that alternate every 90 min with NREM preceding REM. Current findings indicate that the sleep-related epilepsy manifests predominantly during the synchronized stages of sleep; NREM over REM stage. Sleep related hypermotor epilepsy (SHE), benign partial epilepsy with centrotemporal spikes or benign rolandic epilepsy (BECTS), and Panayiotopoulos Syndrome (PS) are three of the most frequently implicated epilepsies occurring during the sleep state. Although some familial types are described, others are seemingly sporadic occurrences. In the present review, we aim to discuss the predominance of sleep-related epilepsy during NREM, established familial links to the pathogenesis of SHE, BECTS and PS, and highlight the present available pharmacotherapy options.

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Intrinsic brain connectivity after partial sleep deprivation in young and older adults: results from the Stockholm Sleepy Brain study

Cited by 50 publications

References 79 publications

Sleep restriction caused impaired emotional regulation without detectable brain activation changes – a functional magnetic resonance imaging study

Sleep restriction caused impaired emotional regulation without detectable brain activation changes – a functional magnetic resonance imaging study

Cognitive vulnerability to sleep deprivation is robustly associated with two dynamic connectivity states

Sleep Related Epilepsy and Pharmacotherapy: An Insight

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