Intrinsic bioactivity of black phosphorus nanomaterials on mitotic centrosome destabilization through suppression of PLK1 kinase

Shao, Ximing; Ding, Zhihao; Zhou, Wenhua; Li, Yanyan; Li, Zhibin; Cui, Haodong; Lin, Xian; Cao, Guoli; Cheng, Binghua; Sun, Haiyan; Li, Meiqing; Liu, Ke; Lu, Danyi; Geng, Shengyong; Shi, Wei; Zhang, Guofang; Song, Qingle; Chen, Liang; Wang, Guocheng; Wu, Songhua; Cai, Lintao; Fang, Lijing; Leong, David Tai; Li, Yang; Yu, Xue‐Feng; Li, Hongchang

doi:10.1038/s41565-021-00952-x

Cited by 81 publications

(71 citation statements)

References 48 publications

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“…It has been reported previously that BPNS can directly affect the cell mitosis then promote apoptosis. [ 33 ] Consistently, as demonstrated in Figure 4b, BPNS@SMFN conducted the certain inhibition on the tumor cell growth after 24 h coincubation. Nonetheless, the cell viability was all beyond 85% even though the phosphorus concentration reached up to 240 mg mL −1 phosphorus, indicating that the toxicity effect of BPNS@SMFN were comparatively low.…”

Section: Resultssupporting

confidence: 72%

Temperature‐Dependent CAT‐Like RGD‐BPNS@SMFN Nanoplatform for PTT‐PDT Self‐Synergetic Tumor Phototherapy

Song

Chen

Qin

et al. 2021

Adv Healthcare Materials

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Phototherapies such as photothermal therapy (PTT) and photodynamic therapy (PDT) are considered as alternatives for tumor remedies, because of their advantages of precise spatial orientation, minimally invasive, and nonradiative operation. However, most of phototherapeutic agents still suffer from low photothermal conversion efficacy and photodynamic performance, poor biocompatibility, and intratumor accumulation. Herein a biocompatible and target-deliverable PTT-PDT self-synergetic nanoplatform of RGD-BPNS@SMFN based on temperature-dependent catalase (CAT)-like behavior for tumor elimination is presented. The homogeneously dispersible nanoplatform is designed and fabricated through anchoring spherical manganese ferrite nanoparticles (SMFN) to black phosphorus nanosheets (BPNS), followed by arginine-glycine-aspartic acid (RGD) peptide modification. The nanoplatform exhibits excellent targeting ability and enhanced photonic response in comparison to plain BPNS and SMFN in vitro and in vivo. It is found that PTT and PDT have a self-synergetic behavior by means of the dual phototherapy mode interaction. The self-synergetic mechanism is mainly ascribed to PTT-promoted inherent CAT-like activity in the nanoplatform, which remodels the tumor hypoxia microenvironment and further ameliorates the PDT efficiency, providing promising high performance nanoplatform for synergetic dual mode phototherapy, enriching the design for the antitumor nanozyme.

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Section: Resultssupporting

confidence: 72%

Temperature‐Dependent CAT‐Like RGD‐BPNS@SMFN Nanoplatform for PTT‐PDT Self‐Synergetic Tumor Phototherapy

Song

Chen

Qin

et al. 2021

Adv Healthcare Materials

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“…In addition, in particular for immuno-oncotherapies aiming at activating specific anti-tumor immunity, the therapeutic approach is effective only for a limited number of patients, which depended on the degree of the immunogenicity for various tumor types (8). In an effort to improve the efficacy and safety of the immuno-oncotherapy, many studies have focused on the use of engineered nanoparticles (NPs) (9)(10)(11)(12). In this context, magnetite nanoparticles (MNPs) are already in use for medical purposes, e.g., in iron replacement therapy and magnetic resonance imaging (MRI), approved by the US Food and Drug Administration (FDA) (13,14).…”

Section: Introductionmentioning

confidence: 99%

Applications of Magnetite Nanoparticles in Cancer Immunotherapies: Present Hallmarks and Future Perspectives

et al. 2021

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Current immuno-oncotherapeutic protocols that inhibit tumor immune evasion have demonstrated great clinical success. However, the therapeutic response is limited only to a percentage of patients, and the immune-related adverse events can compromise the therapeutic benefits. Therefore, improving cancer immunotherapeutic approaches that pursue high tumor suppression efficiency and low side effects turn out to be a clinical priority. Novel magnetite nanoparticles (MNPs) exhibit great potential for therapeutic and imaging applications by utilizing their properties of superparamagnetism, good biocompatibility, as well as the easy synthesis and modulation/functionalization. In particular, the MNPs can exert magnetic hyperthermia to induce immunogenic cell death of tumor cells for effective antigen release and presentation, and meanwhile polarize tumor-associated macrophages (TAMs) to M1 phenotype for improved tumor killing capability, thus enhancing the anti-tumor immune effects. Furthermore, immune checkpoint antibodies, immune-stimulating agents, or tumor-targeting agents can be decorated on MNPs, thereby improving their selectivity for the tumor or immune cells by the unique magnetic navigation capability of MNPs to promote the tumor killing immune therapeutics with fewer side effects. This mini-review summarizes the recent progress in MNP-based immuno-oncotherapies, including activation of macrophage, promotion of cytotoxic T lymphocyte (CTL) infiltration within tumors and modulation of immune checkpoint blockade, thus further supporting the applications of MNPs in clinical therapeutic protocols.

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“…14−16 These inorganic photothermal nanoagents suffer from long retention time in the body and nonbiodegradability, which may induce long-term toxicity. 17 Therefore, there is still an urgent need to develop alternative and novel photothermal therapeutic systems.…”

Section: ■ Introductionmentioning

confidence: 99%

“…Phototherapy holds exciting promise for cancer therapy due to its low toxicity, noninvasive activation, and high therapeutic efficacy. − In comparison with the traditional therapy strategies including chemotherapy and radiotherapy, light-activated therapy holds the potential to minimize the side effects of drugs and optimize the tissue selectivity. − In particular, photothermal therapy (PTT) utilizes a photoabsorptive agent to generate heat to eradicate cancer cells. ,, By virtue of high near-infrared (NIR) extinction coefficients, conventional NIR dyes including indocyanine green (ICG), Cypate, IR825, IR780, and IR820 show potential as photothermal molecules for the tumor treatment; , however, their poor photostability and low hydrophilicity greatly limit their clinical use . An increasing number of inorganic nanomaterials with high NIR absorption coefficients have been reported for photothermal tumor ablation, such as gold nanoparticles and quantum dots (QDs). − These inorganic photothermal nanoagents suffer from long retention time in the body and nonbiodegradability, which may induce long-term toxicity . Therefore, there is still an urgent need to develop alternative and novel photothermal therapeutic systems.…”

Section: Introductionmentioning

confidence: 99%

Oxygenic Enrichment in Hybrid Ruthenium Sulfide Nanoclusters for an Optimized Photothermal Effect

Zhu

Liu

et al. 2021

ACS Appl. Mater. Interfaces

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Transition-metal dichalcogenide (TMD)-based nanomaterials have been extensively explored for the photonic therapy. To the best of our knowledge, near-infrared (NIR) light is a requirement for the photothermal therapy (PTT) to achieve the feature of deep-tissue penetration, whereas no obvious absorption peaks existing in the NIR region for existing TMD nanomaterials limit their therapeutic efficacy. As one category of TMD nanomaterials, ruthenium sulfide-based nanomaterials have been less exploited in biomedical applications including tumor therapy so far. Here, we develop a facile biomineralization-assisted bottomup strategy to synthesize oxygenic hybrid ruthenium sulfide nanoclusters (RuS x NCs) by regulating the oxygen amounts and sulfur defects for the optimized PTT. By regulating the increasing initial molar ratios of Ru to S, RuS x NCs with small sizes were endowed with increasing oxygen contents and sulfur defects, leading to the photothermal conversion efficiency (PCE) increasing from 32.8 to 41.9%, which were higher than that of most small-sized inorganic photothermal nanoagents. In contrast to commercial indocyanine green, these RuS x NCs exhibited higher photostability under NIR laser irradiation. The high PCE and superior photostability allowed RuS x NCs to effectively and completely ablate cancer cells. Thus, the proposed defect engineering strategy endows RuS x NCs with an excellent photothermal effect for the PTT of tumors of living mice, which also proves the potential of further exploring the properties of RuS x NCs for future biomedical applications.

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Intrinsic bioactivity of black phosphorus nanomaterials on mitotic centrosome destabilization through suppression of PLK1 kinase

Cited by 81 publications

References 48 publications

Temperature‐Dependent CAT‐Like RGD‐BPNS@SMFN Nanoplatform for PTT‐PDT Self‐Synergetic Tumor Phototherapy

Temperature‐Dependent CAT‐Like RGD‐BPNS@SMFN Nanoplatform for PTT‐PDT Self‐Synergetic Tumor Phototherapy

Applications of Magnetite Nanoparticles in Cancer Immunotherapies: Present Hallmarks and Future Perspectives

Oxygenic Enrichment in Hybrid Ruthenium Sulfide Nanoclusters for an Optimized Photothermal Effect

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