Intrinsic and Input‐dependent Development of Cortical Neuron Types

Klingler, Esther; Puiggros, SergiRoig; Jabaudon, Denis

doi:10.1002/9781119860914.ch14

Cited by 2 publications

(2 citation statements)

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“…Questions around how brain development proceeds typically invoke answers that rely on a separation between so-called intrinsic and extrinsic factors. Within developmental neuroscience, intrinsic aspects are generally taken to be those that reliably proceed without clear dependence on sensory input, whereas extrinsic aspects are framed as being more open to being shaped by external input relayed through sensory systems (e.g., Klingler et al, 2023). Similarly, influential theorizing in developmental science about the "effects of early experience" in humans has implicitly assumed a separation between intrinsically developing aspects of brain development and aspects that depend on stimuli delivered from the external environment (e.g., Greenough et al, 1987;Johnson & Morton, 1991).…”

Section: Beyond Intrinsic and Extrinsic Factors In Early Brain Develo...mentioning

confidence: 99%

Towards a Biologically Coherent Account of the Brain and How it Develops

Marshall

2024

Preprint

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As the sophistication and reach of neuroscience methods increase, it is important to understand the implications of different conceptualizations of brain function. Considering the evolution of the vertebrate brain illustrates how brain function must always be considered in the context of the goal-directed activity of the organism. The brain does not simply mediate between stimulus and response but is instead part of a reafferent loop that begins and ends with the activity of the organism. However, this emphasis on the inherently active individual is lost if we adopt a view of the brain as a computational device that passively processes input delivered to it from an external world. In this latter view, the organism is instructed by external information, but this approach fails to appreciate that the origin of all information reaching the brain is the activity of the organism itself. Related conceptual confusions about the nature of information characterize accounts of brain development that rely on the notion of instructions encoded in DNA. A more biologically coherent approach to brain development comes from theorizing in embodiment that emphasizes the inherent activity of the organism in the context of the wider developmental system.

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Section: Beyond Intrinsic and Extrinsic Factors In Early Brain Develo...mentioning

confidence: 99%

Towards a Biologically Coherent Account of the Brain and How it Develops

Marshall

2024

Preprint

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“…In turn, these conclusions have implications for the study of brain development, which typically relies on a separation between so-called intrinsic and extrinsic factors. Within developmental neuroscience, intrinsic aspects are generally taken to be those that reliably proceed without clear dependence on sensory input, whereas extrinsic aspects are more open to being shaped by external input relayed through sensory systems (e.g., Klingler et al, 2023).…”

Section: Beyond Intrinsic and Extrinsic Factors In Early Brain Develo...mentioning

confidence: 99%

Towards a Biologically Coherent Account of the Brain and How It Develops

Marshall

2024

Human Development

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Different conceptualizations of brain function have different implications for understanding the relation of neuroscience to the study of human development. In one view, the brain is an isolated computational device that passively processes stimuli delivered from an external world and then mediates a response. An alternative view, which is more consistent with the evolutionary history of brains, moves away from simple causal linkages between stimulus and response and instead emphasizes the inherent, ongoing activity of the individual. Here the individual is not directly instructed by information from its environment but instead shapes its own sensory inputs through its goal-directed activity. Related conceptual confusions around instructions and information can be found in accounts of brain development that either fall back on a genetic blueprint or that elevate the role of extrinsic experience. A more coherent approach brings together aspects of developmental and evolutionary biology while drawing on developmental systems theory and particular themes in embodied cognitive science. Such an approach spans qualitatively different frames of explanation across a range of spatiotemporal scales, necessitating a reconsideration of disciplinary boundaries. Fully engaging in this effort can yield a more integrative science of brain, mind, and behavior and an enriched understanding of human development.

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Intrinsic and Input‐dependent Development of Cortical Neuron Types

Cited by 2 publications

References 124 publications

Towards a Biologically Coherent Account of the Brain and How it Develops

Towards a Biologically Coherent Account of the Brain and How it Develops

Towards a Biologically Coherent Account of the Brain and How It Develops

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