Intrinsic and cooperative antigen-presenting functions of dendritic-cell subsets in vivo

Villadangos, José A; Schnorrer, Petra

doi:10.1038/nri2103

Cited by 569 publications

(584 citation statements)

References 138 publications

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Section: Introductionmentioning

confidence: 99%

“…[1][2][3] DCs are represented by two major lineages, classical or conventional DCs (cDCs) and plasmacytoid DCs (pDCs). [1][2][3] cDCs have outstanding capacity to prime naive T cells to generate various types of effector T (T eff ) cells owing to the prominent expression of major histocompatibility complex class (MHC) II and costimulatory molecues. [4][5][6] On the other hand, pDCs are specialized in endosomal TLR7/9-mediated recognition of viral nucleic acids (NAs) and respond with the massive secretion of type I interferon (IFN-I).…”

Section: Introductionmentioning

confidence: 99%

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Crucial role of plasmacytoid dendritic cells in the development of acute colitis through the regulation of intestinal inflammation

et al. 2017

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Crucial role of plasmacytoid dendritic cells in the development of acute colitis through the regulation of intestinal inflammation

et al. 2017

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“…by inducing preferentially CD4 1 or CD8 1 T-cell responses or by inducing innate immunity against pathogens [4,5]. Langerhans cells (LCs) are a subset of DCs that are, in humans, characterized by expression of CD1a, the C-type lectin Langerin and the presence of Birbeck granules [6].…”

Section: Introductionmentioning

confidence: 99%

Human Langerhans cells capture measles virus through Langerin and present viral antigens to CD4⁺ T cells but are incapable of cross‐presentation

et al. 2011

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Langerhans cells (LCs) are a subset of DCs that reside in the upper respiratory tract and are ideally suited to sense respiratory virus infections. Measles virus (MV) is a highly infectious lymphotropic and myelotropic virus that enters the host via the respiratory tract. Here, we show that human primary LCs are capable of capturing MV through the C-type lectin Langerin. Both immature and mature LCs presented MV-derived antigens in the context of HLA class II to MV-specific CD4 1 T cells. Immature LCs were not susceptible to productive infection by MV and did not present endogenous viral antigens in the context of HLA class I. In contrast, mature LCs could be infected by MV and presented de novo synthesized viral antigens to MV-specific CD8 1 T cells. Notably, neither immature nor mature LCs were able to cross-present exogenous UV-inactivated MV or MV-infected apoptotic cells. The lack of direct infection of immature LCs, and the inability of both immature and mature LCs to crosspresent MV antigens, suggest that human LCs may not be directly involved in priming MV-specific CD8 1 T cells. Immune activation of LCs seems a prerequisite for MV infection of LCs and subsequent CD8 1 T-cell priming via the endogenous antigen presentation pathway. Eur. J. Immunol. 2011. 41: 2619-2631 DOI 10.1002 Immunity to infection 2619 molecules, a process referred to as cross-presentation which is thought to be important in both viral and tumor immunity [2,3]. It is becoming evident that different DC subsets have specialized functions in anti-viral immunity, e.g. by inducing preferentially CD4 1 or CD8 1 T-cell responses or by inducing innate immunity against pathogens [4,5]. Langerhans cells (LCs) are a subset of DCs that are, in humans, characterized by expression of CD1a, the C-type lectin Langerin and the presence of Birbeck granules [6]. LCs reside in the epidermis and stratified epithelial tissues [7][8][9]. Recently, we have shown that LCs form a barrier against HIV-1; LCs capture HIV-1 through Langerin, resulting in internalization of HIV-1 into Birbeck granules and preventing subsequent HIV-1 transmission [10]. However, little is known about the role of human LCs and Langerin in antigen presentation.Capture of exogenous antigens by LCs leads to induction of CD4 1 T-cell responses [11][12][13]. However, the ability of LCs to cross-present exogenous antigens to CD8 1 T cells has been debated [14][15][16][17]. Klechevsky et al. [13] have shown that in vitrogenerated human LCs from either CD34 1 cells or monocytes are capable of cross-presenting influenza-virus proteins to CD8 1 T cells. However, these in vitro-generated LCs might be different from primary immature LCs.Here, we have investigated the antigen capture and presentation capacity of human primary LCs during measles virus (MV) infection. MV is the causative agent of measles, which remains an important cause of morbidity and mortality in developing countries. MV is a lymphotropic and myelotropic virus and DCs have been implicated in its transmission [18,19]. MV is on...

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“…In the present study, we demonstrated that DCs require the participation of macrophages to generate protective immune responses against Lm infection and macrophage-released MPs act as a vector to bridge DCs and macrophages. DCs are believed to be specialized in capturing and processing antigens in vivo, 32,33 converting protein antigens to peptides that are presented on MHC molecules and recognized by T cells. Through interactions with DCs, helper T cells differentiate into either Th1 cells, which produce IFN-c to resist infection by facultative and obligate intracellular microbes such as Lm, Th2 cells that produce IL-4 and IL-13 to mobilize immune cells to resist helminths, or Th17 cells producing IL-17 and IL-22 to mobilize phagocytic cells to eliminate …”

Section: Discussionmentioning

confidence: 99%

Microparticles released by Listeria monocytogenes-infected macrophages are required for dendritic cell-elicited protective immunity

Zhang

et al. 2012

Cell Mol Immunol

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Intrinsic and cooperative antigen-presenting functions of dendritic-cell subsets in vivo

Cited by 569 publications

References 138 publications

Crucial role of plasmacytoid dendritic cells in the development of acute colitis through the regulation of intestinal inflammation

Crucial role of plasmacytoid dendritic cells in the development of acute colitis through the regulation of intestinal inflammation

Human Langerhans cells capture measles virus through Langerin and present viral antigens to CD4⁺ T cells but are incapable of cross‐presentation

Microparticles released by Listeria monocytogenes-infected macrophages are required for dendritic cell-elicited protective immunity

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Intrinsic and cooperative antigen-presenting functions of dendritic-cell subsets in vivo

Cited by 569 publications

References 138 publications

Crucial role of plasmacytoid dendritic cells in the development of acute colitis through the regulation of intestinal inflammation

Crucial role of plasmacytoid dendritic cells in the development of acute colitis through the regulation of intestinal inflammation

Human Langerhans cells capture measles virus through Langerin and present viral antigens to CD4+ T cells but are incapable of cross‐presentation

Microparticles released by Listeria monocytogenes-infected macrophages are required for dendritic cell-elicited protective immunity

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Human Langerhans cells capture measles virus through Langerin and present viral antigens to CD4⁺ T cells but are incapable of cross‐presentation