Intrinsic Adhesion Properties of Poly(vinyl pyrrolidone) to Pharmaceutical Materials: Humidity Effect

Lee, Jonghwi

doi:10.1002/mabi.200500146

Cited by 33 publications

(13 citation statements)

References 39 publications

(218 reference statements)

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“…For both methods, the blend films were manufactured using compression molding at 270 °C. In the first method, the blend sample was adhered to the polyimide foil using the aqueous PVP solution as PVP has adhesive properties [ 58 ]. The samples were allowed to dry for up to 24 h. In the second method, the temperature used for compression molding was 240 °C for PVP K 90.…”

Section: Experimental and Methodologymentioning

confidence: 99%

Open-Celled Foams of Polyethersulfone/Poly(N-vinylpyrrolidone) Blends for Ultrafiltration Applications

et al. 2022

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Since membranes made of open porous polymer foams can eliminate the use of organic solvents during their manufacturing, a series of previous studies have explored the foaming process of various polymers including polyethersulfone (PESU) using physical blowing agents but failed to produce ultrafiltration membranes. In this study, blends containing different ratios of PESU and poly(N-vinylpyrrolidone) (PVP) were used for preparation of open-celled polymer foams. In batch foaming experiments involving a combination of supercritical CO2 and superheated water as blowing agents, blends with low concentration of PVP delivered uniform open-celled foams that consisted of cells with average cell size less than 20 µm and cell walls containing open pores with average pore size less than 100 nm. A novel sample preparation method was developed to eliminate the non-foamed skin layer and to achieve a high porosity. Flat sheet membranes with an average cell size of 50 nm in the selective layer and average internal pore size of 200 nm were manufactured by batch foaming a PESU blend with higher concentration of PVP and post-treatment with an aqueous solution of sodium hypochlorite. These foams are associated with a water-flux up to 45 L/(h m² bar). Retention tests confirmed their applicability as ultrafiltration membranes.

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Section: Experimental and Methodologymentioning

confidence: 99%

Open-Celled Foams of Polyethersulfone/Poly(N-vinylpyrrolidone) Blends for Ultrafiltration Applications

et al. 2022

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“…Although the structure was severely deformed by compression, no crack was identified at the PLGA–PVP interface, confirming that reliable adhesion between two layers was achieved. We anticipate that the adhesive properties of PVP [42,43] contributed to the structural integrity, which is highly important to ensure the insertion of microneedles without breakage.…”

Section: Resultsmentioning

confidence: 99%

Spray-Formed Layered Polymer Microneedles for Controlled Biphasic Drug Delivery

Park

Kim

Baek³

et al. 2019

Polymers

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In this study we present polymeric microneedles composed of multiple layers to control drug release kinetics. Layered microneedles were fabricated by spraying poly(lactic-co-glycolic acid) (PLGA) and polyvinylpyrrolidone (PVP) in sequence, and were characterized by mechanical testing and ex vivo skin insertion tests. The compression test demonstrated that no noticeable layer separation occurred, indicating good adhesion between PLGA and PVP layers. Histological examination confirmed that the microneedles were successfully inserted into the skin and indicated biphasic release of dyes incorporated within microneedle matrices. Structural changes of a model protein drug, bovine serum albumin (BSA), in PLGA and PVP matrices were examined by circular dichroism (CD) and fluorescence spectroscopy. The results showed that the tertiary structure of BSA was well maintained in both PLGA and PVP layers while the secondary structures were slightly changed during microneedle fabrication. In vitro release studies showed that over 60% of BSA in the PLGA layer was released within 1 h, followed by continuous slow release over the course of the experiments (7 days), while BSA in the PVP layer was completely released within 0.5 h. The initial burst of BSA from PLGA was further controlled by depositing a blank PLGA layer prior to forming the PLGA layer containing BSA. The blank PLGA layer acted as a diffusion barrier, resulting in a reduced initial burst. The formation of the PLGA diffusion barrier was visualized using confocal microscopy. Our results suggest that the spray-formed multilayer microneedles could be an attractive transdermal drug delivery system that is capable of modulating a drug release profile.

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“…Our data also suggest that the adhesion between PLGA and PVP layers was strong enough to resist breaking at the layer interface. We anticipate that adhesive properties of PVP facilitate the successful binding between two layers (Lee, 2005 ; Teodorescu and Bercea, 2015 ).…”

Section: Discussionmentioning

confidence: 99%

Fabrication of Circular Obelisk-Type Multilayer Microneedles Using Micro-Milling and Spray Deposition

Kim

Park

Rizal

et al. 2018

Front. Bioeng. Biotechnol.

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In this study we present the fabrication of multilayer microneedles with circular obelisk and beveled-circular obelisk geometries, which have potential applications in implantable drug delivery devices. Micro-milling was adopted as an environmental-friendly and cost-effective way to fabricate primary metal microneedle masters. Polylactic acid (PLA) microneedles with sharp tips were then obtained by micromolding followed by oxygen plasma etching and used for preparing polydimethylsiloxane (PDMS) microneedle molds. A spray deposition process was employed for microneedle fabrication to facilitate the formation of multilayer microneedles while helping in maintenance of drug stability. Multilayer microneedles were successfully formed by sequential spraying of poly(lactic-co-glycolic acid) (PLGA) and polyvinylpyrrolidone (PVP) solutions into the mold. The fabricated PLGA-PVP multilayer microneedles penetrated the pig cadaver skin without breakage and released dyes in the skin at different rates, which reveals the potential for implantable microneedles enabling controlled release. Mechanical testing demonstrated that the obelisk-shaped microneedles were mechanically stronger than a pyramid-shaped microneedle and suggested that strong adhesion between PLGA and PVP layers was achieved as well. Structural stability and functionality of a model drug, horseradish peroxidase (HRP), upon spray deposition was examined using circular dichroism (CD) spectroscopy and enzyme activity assay. HRP retained its secondary structure and activity in PVP, whereas HRP in PLGA showed structural changes and reduced activity. Combination of micro-milling and spray deposition would be an attractive way of fabricating drug-containing polymer microneedles with various geometries while reducing prototyping time and process-induced drug instability.

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Intrinsic Adhesion Properties of Poly(vinyl pyrrolidone) to Pharmaceutical Materials: Humidity Effect

Cited by 33 publications

References 39 publications

Open-Celled Foams of Polyethersulfone/Poly(N-vinylpyrrolidone) Blends for Ultrafiltration Applications

Open-Celled Foams of Polyethersulfone/Poly(N-vinylpyrrolidone) Blends for Ultrafiltration Applications

Spray-Formed Layered Polymer Microneedles for Controlled Biphasic Drug Delivery

Fabrication of Circular Obelisk-Type Multilayer Microneedles Using Micro-Milling and Spray Deposition

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