Intrinsic abnormalities of adipose tissue and adipose tissue dysfunction in PCOS

Spritzer, Poli Mara; Santos, Betânia Rodrigues dos; Fighera, Tayane Muniz; Marchesan, Lucas Bandeira; Lecke, Sheila Bünecker

doi:10.1016/b978-0-12-823045-9.00005-5

Cited by 4 publications

(7 citation statements)

References 185 publications

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“…Poli Mara Spritzer 1,2 https://orcid.org/0000-0002-5204-107X P olycystic ovary syndrome (PCOS) is a multifactorial condition, characterized by clinical or biochemical hyperandrogenism, ovarian dysfunction, and/or polycystic ovaries. Insulin resistance and central adiposity are often present, and women with PCOS are at higher risk for metabolic comorbidities, such as dyslipidemia, prediabetes, and type 2 diabetes (1).…”

Section: Inflammatory Mediators In Polycystic Ovary Syndrome: the Cas...mentioning

confidence: 99%

“…Current evidence suggests that women with PCOS have increased serum proinflammatory markers when compared to healthy controls, contributing to a chronic low-grade inflammatory state (2). Indeed, major pro-inflammatory cytokines, such as IL-6 and TNFα, may be derived from dysfunctional adipose tissue in PCOS and primarily secreted by resident macrophages (1). IL-6 induces the hepatic production of CRP, and women with PCOS exhibit elevated CRP levels, which are correlated with obesity and insulin resistance (3).…”

Section: Inflammatory Mediators In Polycystic Ovary Syndrome: the Cas...mentioning

confidence: 99%

See 1 more Smart Citation

Inflammatory mediators in polycystic ovary syndrome: the case of interleukin-18

Spritzer

2022

Archives of Endocrinology and Metabolism

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Section: Inflammatory Mediators In Polycystic Ovary Syndrome: the Cas...mentioning

confidence: 99%

Section: Inflammatory Mediators In Polycystic Ovary Syndrome: the Cas...mentioning

confidence: 99%

Inflammatory mediators in polycystic ovary syndrome: the case of interleukin-18

Spritzer

2022

Archives of Endocrinology and Metabolism

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“…7,8 Adipose tissue secretes adipokines, most notably leptin and adiponectin. 9,10 Leptin is thought to be importantly involved in regulating food intake, metabolism, and reproduction. Some studies found significantly higher leptin levels in PCOS women than in those who have regular menstruation, and leptin levels were positively correlated with insulin resistance.…”

Section: Introductionmentioning

confidence: 99%

“…Some studies found significantly higher leptin levels in PCOS women than in those who have regular menstruation, and leptin levels were positively correlated with insulin resistance. [9][10][11] A study shows that giving insulin sensitizer can reduce leptin and insulin levels and improve reproductive function in PCOS patients. 12 In contrast, adiponectin improves insulin sensitivity and has an anti-inflammatory effect.…”

Section: Introductionmentioning

confidence: 99%

Body Composition Parameters, Adiponectin, Leptin and Adiponectin/Leptin Ratio are Correlated with LH/FSH Ratio in Women with PCOS but not in Women without PCOS

Gita Pratama,

Wiweko,

Asmarinah

et al. 2024

Indones J Obstet Gynecol

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Objective: To investigate the correlation between body composition parameters, adiponectin, leptin and the adiponectin/leptin ratio and the LH/FSH ratio in women with polycystic ovary syndrome (PCOS). Methods: A cross-sectional study was conducted at Reproductive Cluster Yasmin, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, with sixty women with PCOS and sixty healthy women as controls (matched for age and BMI). Body composition parameters, including body weight, body mass index (BMI), waist circumference (WC), waist to hip ratio (WHR), percent body fat (PBF), visceral fat area (VFA), percent subcutaneous fat (PSF) and skeletal muscle mass (SMM), were measured; levels of fasting glucose, fasting insulin, testosterone, and sex hormone binding globulin (SHBG) were measured; and homeostatic model assessment for insulin resistance (HOMA-IR) values, anti-Mullerian hormone (AMH), free androgen index (FAI), Ferriman-Gallwey (FG) score, adiponectin levels, leptin levels, adiponectin/leptin ratio, LH, FSH and LH/FSH ratio were measured. Results: Body composition parameters (body weight, BMI, WC, WHR, PBF, VFA, PSF, SMM) were not significantly different between women with PCOS and controls. Fasting insulin (P<0.05), HOMA-IR (P<0.05), AMH (P<0.01), FAI (P<0.01), FG score (P<0.01) and LH/FSH ratio (P<0.05) were higher in PCOS women. Adiponectin (P<0.01) was lower in PCOS women, while leptin and the adiponectin/leptin ratio were not significantly different between groups. Most of body composition parameters, adiponectin, leptin and adiponectin/leptin ratio were correlated with HOMA-IR in both groups. SMM was positively correlated with the LH/FSH ratio, while body weight, BMI, WC, PBF, VFA, and PSF were inversely correlated with the LH/FSH ratio in PCOS patients but not in controls. WHR was not correlated in either group. Leptin (r=-0.278; P<0.05) was negatively correlated with the LH/FSH ratio only in the PCOS group. Adiponectin (r=0.394; P<0.01) and the adiponectin/leptin ratio (r=0.413; P<0.01) were also positively correlated with the LH/FSH ratio only in the PCOS group. AMH was correlated with the LH/FSH ratio, whereas testosterone level, FAI, FG score, fasting insulin level and HOMA-IR value were not correlated with the LH/FSH ratio in PCOS women. Conclusion: Most of the body composition parameters, leptin, adiponectin and the adiponectin/leptin ratio were significantly correlated with HOMA-IR in both groups. However, correlations of those parameters with LH/FSH ratio were found only in PCOS but not in women without PCOS. Adiponectin and leptin may play a significant role in the mechanism of neuroendocrine disorders in PCOS, which is characterized by an increased LH/FSH ratio. Keywords: adiponectin, adiponectin/leptin ratio, body composition, HOMA-IR, leptin, LH/FSH ratio, PCOS

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“…Insulin resistance and central obesity are often present in patients with PCOS, features that are strongly associated with adipose tissue dysfunction [ 7 ]. Obesity is clearly related to insulin resistance, but even lean women with PCOS are prone to develop insulin resistance [ 8 , 9 ], affecting about 45% of women as demonstrated in a previous study by our group [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Lean mass and associated factors in women with PCOS with different phenotypes

Fighera,

dos Santos,

Spritzer

2023

PLoS ONE

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Although current evidence suggests increased risk of obesity, insulin resistance, and metabolic alterations in patients with polycystic ovary syndrome (PCOS), especially of a hyperandrogenic phenotype, the impact of each one of these variables on muscle mass remains uncertain. In this case-control study, we evaluated clinical and hormonal characteristics related to lean body mass according to the different PCOS phenotypes. We performed clinical, metabolic, and hormonal assessments and evaluated body compartments by dual-energy X-ray absorptiometry in 133 women of reproductive age. Creatinine served as an indirect marker of lean mass. Median age was 28 (range, 17–37) years. Women with phenotypes A and B (n = 59) had higher body mass index (BMI) and metabolic syndrome prevalence than those with phenotype C (n = 23) and controls (n = 51) (p<0.005). Women with phenotypes A and B also had higher Ferriman-Gallwey score (p<0.001), insulin levels (p = 0.006), HOMA-IR (p = 0.008), testosterone (p = 0.008), free androgen index (FAI) (p<0.001), fat mass index (FMI) (p = 0.015), android-to-gynoid fat ratio (p = 0.036), and bone mineral density (BMD) at lumbar spine (p = 0.027) and total femur (p = 0.013) than controls. Median appendicular lean mass index (ALMI) was higher in phenotypes A and B than in controls (7.01 [IQR, 6.33–8.02] vs. 6.69 [IQR, 5.94–7.09], p = 0.024), but it did not differ significantly from that in phenotype C (6.60 [IQR, 6.16–7.22], p = 0.222). Even after adjusting for BMI, ALMI correlated positively with creatinine in women with phenotypes A and B (rho = 0.319, p = 0.023) but not in those with phenotype C (p = 0.238) or controls (p = 0.097). In multivariate linear regression analyses, ALMI was positively associated with insulin, FAI, FMI, and total femur BMD. The present results suggest that fasting insulin, FAI, fat mass, and total femur BMD were positively associated with increased lean mass in women with PCOS phenotypes A and B.

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Intrinsic abnormalities of adipose tissue and adipose tissue dysfunction in PCOS

Cited by 4 publications

References 185 publications

Inflammatory mediators in polycystic ovary syndrome: the case of interleukin-18

Inflammatory mediators in polycystic ovary syndrome: the case of interleukin-18

Body Composition Parameters, Adiponectin, Leptin and Adiponectin/Leptin Ratio are Correlated with LH/FSH Ratio in Women with PCOS but not in Women without PCOS

Lean mass and associated factors in women with PCOS with different phenotypes

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