Intravoxel incoherent motion MRI assessment of chemoradiation‐induced pelvic bone marrow changes in cervical cancer and correlation with hematological toxicity

Abstract

2 Technical Efficacy: Stage 1 J. Magn. Reson. Imaging 2017;46:1491-1498.

Measurements of Diffusion and Perfusion in Vertebral Bone Marrow Using Intravoxel Incoherent Motion (IVIM) With Multishot, Readout‐Segmented (RESOLVE) Echo‐Planar Imaging

“…In previous IVIM studies on vertebral bone marrow, single-shot EPI sequences have been employed. [3][4][5][6][7][8][9] In the current study the use of a RESOLVE sequence (ie, a segmented readout) allows for 1) an increase of the matrix size, thus the acquisition of images with an improved spatial resolution and 2) the shortening of the EPI echo train, which contributes to reduce the distortions and blurring artifacts on the images. The disadvantage of the RESOLVE sequence, in comparison to the single-shot approach, is the longer acquisition time.…”

“…As a result, the IVIM technique can now be applied to various tissues. Surprisingly, however, only a very limited number of IVIM studies have been performed on bone marrow . This might be due to lipids, which represent a major confounding factor in the quantification of both diffusion and perfusion .…”

“…Surprisingly, however, only a very limited number of IVIM studies have been performed on bone marrow. [3][4][5][6][7][8][9] This might be due to lipids, which represent a major confounding factor in the quantification of both diffusion and perfusion. 10,11 While the effects of the lipids on the quantification of the water (apparent) diffusion coefficient (ADC) in bone marrow have been investigated, 12 little attention has been paid to their effects on the diffusion (D, D*) and perfusion (f ) parameters obtained by the IVIM approach.…”

Diffusion MRI for Assessment of Bone Quality; A Review of Findings in Healthy Aging and Osteoporosis

“…64,68,71 Nonetheless, there have been a few attempts in implementing IVIM imaging for measuring perfusion and diffusion in bone and, specifically, in the context of osteoporosis. 52 Only a few studies have explored IVIM in bone marrow pathologies, [92][93][94][95][96][97][98][99][100][101] among which only two studies have investigated the relationship between BMD and IVIM-derived parameters. 93,101 These studies suggest that with increasing BMD, perfusion-related (fast) diffusion coefficient, D*, increases and true (slow) diffusion coefficient, D, decreases.…”

MRI biomarkers in osseous tumors

“…The biological effects of radiation on bone marrow has been studied with IVIM. One such study analyzed irradiated pelvic bone in cervical cancer patients and another analyzed vertebral bone with cumulative radiation due to CT, radiography, and transarterial chemoembolization for hepatocellular carcinoma . The former study explored short interval changes 3–4 weeks after irradiation, with a median radiation dose of 40 Gy at the time of the follow‐up scan and found no statistical differences in any of the IVIM parameters.…”