Intravoxel incoherent motion (IVIM) MR imaging of colorectal liver metastases: Are we only looking at tumor necrosis?

Chiaradia, M.; Baranès, Laurence; Nhieu, Jeanne Tran Van; Vignaud, Alexandre; Laurent, Alexis; Decaens, Thomas; Charles-Nelson, Anaïs; Brugières, Pierre; Katsahian, Sandrine; Djabbari, M.; Deux, Jean-François; Sobhani, Iradj; Karoui, Mehdi; Rahmouni, Alain; Luciani, Alain

doi:10.1002/jmri.24172

Cited by 65 publications

(69 citation statements)

References 33 publications

(44 reference statements)

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“…Few studies report on the potential value of DW MR imaging for assessing the response of colorectal cancer metastases to chemotherapy [69,70]. Increase in ADC has been reported after treatment.…”

Section: Liver Tumorsmentioning

confidence: 98%

New imaging techniques for liver diseases

Beers

Daire

Garteiser

2015

Journal of Hepatology

106

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Newly developed or advanced methods of ultrasonography and MR imaging provide combined anatomical and quantitative functional information about diffuse and focal liver diseases. Ultrasound elastography has a central role for staging liver fibrosis and an increasing role in grading portal hypertension; dynamic contrast-enhanced ultrasonography may improve tumor characterization. In clinical practice, MR imaging examinations currently include diffusion-weighted and dynamic MR imaging, enhanced with extracellular or hepatobiliary contrast agents. Moreover, quantitative parameters obtained with diffusion-weighted MR imaging, dynamic contrast-enhanced MR imaging and MR elastography have the potential to characterize further diffuse and focal liver diseases, by adding information about tissue cellularity, perfusion, hepatocyte transport function and visco-elasticity. The multiparametric capability of ultrasonography and more markedly of MR imaging gives the opportunity for high diagnostic performance by combining imaging biomarkers. However, image acquisition and post-processing methods should be further standardized and validated in multicenter trials.

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Section: Liver Tumorsmentioning

confidence: 98%

New imaging techniques for liver diseases

Beers

Daire

Garteiser

2015

Journal of Hepatology

106

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“…They founded that ADC and D provided similar accuracy in assessing malignancy (AUC for ADC = 0.770; AUC for D = 0.723). Chiaradia et al [26] found that both D (r = 0.36; p = 0.035) and ADC (r = 0.4; p = 0.02) correlated with the degree of tumor necrosis, although not with viable tumor, in their study of 35 hepatic metastases from CRC. They reported that ADC and D increased within liver metastases after chemotherapy and often referred to these changes as a sign of tumor response to treatment, which corresponds well with our study results.…”

Section: Discussionmentioning

confidence: 94%

Diffusion-Related MRI Parameters for Assessing Early Treatment Response of Liver Metastases to Cytotoxic Therapy in Colorectal Cancer

Joo

Kim

Han

et al. 2016

American Journal of Roentgenology

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“…One of the most conspicuous advantages of IVIM is that it does not require contrast medium injection. It is believed that the IVIM parameters between malignant and benign tumors of the liver are apparently different (11)(12)(13)(14); however, these previous reports were of limited use because they included non-solid tumors, such as cysts, abscesses, or hemangiomas; hypovascular metastatic lesions; and ill-defined tumors like cholangiocarcinoma, which are hard to delineate in the analysis.…”

mentioning

confidence: 99%

Intravoxel incoherent motion: application in differentiation of hepatocellular carcinoma and focal nodular hyperplasia

Luo

Jiang²,

Zhang³

2017

Diagn Interv Radiol

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A mong primary malignant hepatic tumors, hepatocellular carcinoma (HCC) is the most common disease and is highly associated with chronic hepatitis B and cirrhosis. Focal nodular hyperplasia (FNH) is the second most common benign focal liver lesion (1), and although it displays gentle biological behavior generally, it can cause abdominal pain or right upper quadrant discomfort occasionally. In terms of the extent of vascular supply during contrast enhancement, HCC and FNH both show a hyperarterialization pattern. HCC is characterized by rapid washout in portal and delayed phase compared with adjacent liver tissue, while FNH displays isointensity or mild hyperintensity in the venous phase because of its slower washout. Liver-specific contrast agents, such as gadoxetic acid, can provide unique information to diagnose these conditions more precisely; however, such agents increase the cost and time-consumption of diagnosis. Occasionally, HCC and FNH show confounding or atypical appearances on imaging, especially for high-or middle-grade differentiated HCC, leading to confusion, misdiagnosis ( Fig. 1), and even unnecessary interventions. Since the treatment of these two lesions is completely different, avoiding unnecessary invasive treatment or tests, such as biopsy, surgery, or interventional therapy, is vital for the prognosis and quality of life of the patient. Therefore, it is crucial to diagnose these conditions noninvasively and accurately before surgery.Diffusion-weighted imaging (DWI) is a functional technology to detect diffusion of water molecules and permits to capture more detailed disease information. For lesion detection, the signal intensity on diffusion-weighted image depends on several factors, particularly cell density. A B D O M I N A L I MAG I N G O R I G I N A L A R T I C L E PURPOSEWe aimed to explore whether intravoxel incoherent motion (IVIM)-related parameters of hepatocellular carcinoma (HCC) and focal nodular hyperplasia (FNH) demonstrate differences that could be used to differentiate and improve diagnostic efficiency. METHODSA total of 27 patients, including 22 with HCC and 5 with FNH, underwent liver 3.0 T magnetic resonance imaging for routine sequences. They were concurrently examined by IVIM diffusion-weighted imaging (DWI) scanning with 11 different b values (0-800 s/mm 2 ). IVIM-derived parameters, such as pure diffusion coefficient (D), pseudo-diffusion coefficient (D*), perfusion fraction (f ), and apparent diffusion coefficient (ADC total ), were quantified automatically by post-processing software and compared between HCC and FNH groups. A receiver operating characteristic (ROC) curve was then created to predict their diagnostic value. RESULTS

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Intravoxel incoherent motion (IVIM) MR imaging of colorectal liver metastases: Are we only looking at tumor necrosis?

Abstract: ADC variation observed in CRC metastases following systemic chemotherapy reflects a specific increase in free-molecular diffusion (D), in itself correlated to the degree of metastasis necrosis.

Cited by 65 publications

References 33 publications

New imaging techniques for liver diseases

New imaging techniques for liver diseases

Diffusion-Related MRI Parameters for Assessing Early Treatment Response of Liver Metastases to Cytotoxic Therapy in Colorectal Cancer

Intravoxel incoherent motion: application in differentiation of hepatocellular carcinoma and focal nodular hyperplasia

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