Intravoxel incoherent motion diffusion-weighted imaging in stroke patients: initial clinical experience

Yao, Yihao; Zhang, Shun; Tang, Xiangyu; Shi, Jingjing; Zhu, Wenzhen

doi:10.1016/j.crad.2016.04.019

Cited by 29 publications

(42 citation statements)

References 23 publications

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“…5,6 Moreover, with this technique, the affected microvasculature and parenchyma in patients with cerebral small-vessel disease have been demonstrated previously. 7 Unfortunately, the IVIM signal and the resulting measures can be affected by partial volume effects of CSF.…”

Section: Discussionmentioning

confidence: 99%

On the Reproducibility of Inversion Recovery Intravoxel Incoherent Motion Imaging in Cerebrovascular Disease

Wong¹,

Backes²,

Zhang

et al. 2017

AJNR Am J Neuroradiol

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Section: Discussionmentioning

confidence: 99%

On the Reproducibility of Inversion Recovery Intravoxel Incoherent Motion Imaging in Cerebrovascular Disease

Wong¹,

Backes²,

Zhang

et al. 2017

AJNR Am J Neuroradiol

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“…Studies comparing IVIM fD * and ASL blood flow are sparse and inconclusive. In the rat kidney cortex Liang et al found an excellent correlation between fD * and ASL blood flow (0.803, p < 0.0001), while in stroke patients Yao et al found a weak correlation between fD * and ASL cerebral blood flow ( r = 0.39, p = 0.0002), and in the brain of healthy volunteers Wu et al found no correlation between these two parameters.…”

Section: Experimental Considerationsmentioning

confidence: 99%

Intravoxel incoherent motion MRI as a means to measure in vivo perfusion: A review of the evidence

Federau

2017

NMR in Biomedicine

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The idea that in vivo intravoxel incoherent motion magnetic resonance signal is influenced by blood motion in the microvasculature is exciting, because it suggests that local and quantitative perfusion information can be obtained in a simple and elegant way from a few diffusion-weighted images, without contrast injection. When the method was proposed in the late 1980s some doubts appeared as to its feasibility, and, probably because the signal to noise and image quality at the time was not sufficient, no obvious experimental evidence could be produced to alleviate them. Helped by the tremendous improvements seen in the last three decades in MR hardware, pulse design, and post-processing capabilities, an increasing number of encouraging reports on the value of intravoxel incoherent motion perfusion imaging have emerged. The aim of this article is to review the current published evidence on the feasibility of in vivo perfusion imaging with intravoxel incoherent motion MRI.

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“…There are limited numbers of IVIM studies in human ischemic stroke patients . Previous studies have shown that IVIM‐derived perfusion fraction (f) and apparent diffusion coefficient (D) are significantly decreased in the infarcted area.…”

mentioning

confidence: 99%

“…There are limited numbers of IVIM studies in human ischemic stroke patients. [10][11][12][13] Previous studies have shown that IVIM-derived perfusion fraction (f ) and apparent diffusion coefficient (D) are significantly decreased in the infarcted area. However, only patients diagnosed with acute/ subacute ischemic stroke were assessed in these studies.…”

mentioning

confidence: 99%

Quantitative assessment of hyperacute cerebral infarction with intravoxel incoherent motion MR imaging: Initial experience in a canine stroke model

Gao

et al. 2016

Magnetic Resonance Imaging

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Purpose To evaluate the feasibility of intravoxel incoherent motion (IVIM) for the measurement of diffusion and perfusion parameters in hyperacute strokes. Materials and Methods An embolic ischemic model was established with an autologous thrombus in 20 beagles. IVIM imaging was performed on a 3.0 Tesla platform at 4.5 h and 6 h after embolization. Ten b values from 0 to 900 s/mm2 were fitted with a bi‐exponential model to extract perfusion fraction f, diffusion coefficient D, and pseudo‐diffusion coefficient D*. Additionally, the apparent diffusion coefficient (ADC) was calculated using the mono‐exponential model with all the b values. Statistical analysis was performed using the pairwise Student's t test and Pearson's correlation test. Results A significant decrease in f and D was observed in the ischemic area when compared with those in the contralateral side at 4.5 h and 6 h after embolization (P < 0.01 for all). No significant difference was observed in D* between the two sides at either time point (P = 0.086 and 0.336, respectively). In the stroke area, f at 6 h was significantly lower than that at 4.5 h (P = 0.016). A significantly positive correlation was detected between ADC and D in both stroke and contralateral sides at 4.5 h and 6 h (P < 0.001 for both). Significant correlation between ADC and f was only observed in the contralateral side at 4.5 h and 6 h (P = 0.019 and 0.021, respectively). Conclusion IVIM imaging could simultaneously evaluate the diffusion and microvascular perfusion characteristics in hyperacute strokes. Level of Evidence:2 Technical Efficacy: Stage 1 J. MAGN. RESON. IMAGING 2017;46:550–556

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Intravoxel incoherent motion diffusion-weighted imaging in stroke patients: initial clinical experience

Cited by 29 publications

References 23 publications

On the Reproducibility of Inversion Recovery Intravoxel Incoherent Motion Imaging in Cerebrovascular Disease

On the Reproducibility of Inversion Recovery Intravoxel Incoherent Motion Imaging in Cerebrovascular Disease

Intravoxel incoherent motion MRI as a means to measure in vivo perfusion: A review of the evidence

Quantitative assessment of hyperacute cerebral infarction with intravoxel incoherent motion MR imaging: Initial experience in a canine stroke model

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