Intravitreal triamcinolone for uveitic cystoid macular edema: an optical coherence tomography study

Antcliff, Richard J; Spalton, David J.; Stanford, Miles; Graham, Elizabeth; Ffytche, T. J.; Marshall, John

doi:10.1016/s0161-6420(00)00658-8

Cited by 409 publications

(201 citation statements)

References 42 publications

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“…Optical coherence tomography has also been used to diagnose, assess, and monitor the therapeutic response in uveitic macular edema [48,51,[69][70][71][72][73][74][75][76][77][78][79][80][81][82][83][84][85]. In a recent study, Sugar et al [86] tried to identify a clinically meaningful threshold for change in uveitic macular edema evaluated by OCT. A 20 % change in retinal thickness in patients with uveitic macular edema was found to be optimal for clinically important changes in visual acuity.…”

Section: Use Of Optical Coherence Tomography Technology In Uveitis Prmentioning

confidence: 99%

Optical coherence tomography imaging in uveitis

et al. 2013

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Section: Use Of Optical Coherence Tomography Technology In Uveitis Prmentioning

confidence: 99%

Optical coherence tomography imaging in uveitis

et al. 2013

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“…[1][2][3] It has gained in popularity as a treatment for macular oedema, as studies have shown improved visual acuity and reduced macular thickness following intravitreal triamcinolone acetonide injection. However, most studies suggesting a treatment benefit have been limited by the short follow-up of treated patients.…”

Section: Introductionmentioning

confidence: 99%

Intravitreal triamcinolone acetonide for macular oedema owing to retinal vein occlusion

Patel

Zaheer

Karia

2006

Eye

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“…Injection of intravitreal triamcinolone (ivTA) with dosage ranging from 2 to 25 mg has been used to treat macular oedema arising from a variety of causes. [11][12][13][14] The early treatment in diabetic retinopathy study (ETDRS) demonstrated the benefits of laser photocoagulation in reducing progressive visual loss and persistent oedema in patients with CSMO. 15 However, only 14.5% of patients gained visual improvement 3 years after initial grid laser treatment.…”

Section: Introductionmentioning

confidence: 99%

Phacoemulsification with intravitreal triamcinolone in patients with cataract and coexisting diabetic macular oedema: a 6-month prospective pilot study

Lam

Chan

Mohamed

et al. 2004

Eye

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Aims To assess the safety and efficacy of phacoemulsification with intravitreal triamcinolone (ivTA) injection in diabetics with cataract and clinically significant macular oedema (CSMO). Methods A total of 19 eyes of 15 consecutive diabetic patients with cataract and CSMO were prospectively recruited. Patients underwent phacoemulsification and intraocular lens implantation with 4 mg ivTA injection at completion of surgery. Patients were followed up on day 1, then weekly for 1 month, and thereafter monthly until 6 months postoperatively. Best corrected visual acuity (BCVA), central macular thickness (CMT) measured by optical coherence tomography, and adverse events were recorded. Results In total, 17 eyes completed 6 months of follow-up. In all, 58.8% showed improvement in BCVA of X2 lines, with statistically significant improvement in mean Snellen BCVA of 2.4 lines at 6 months. The peak BCVA was achieved at 4 months. The mean CMT decreased from a baseline of 449 mm to a minimum of 3217148 mm (28.5% reduction) achieved at 2 months, with statistically significant reduction at all postoperative time intervals until 6 months. Of 17 eyes, 4 (23.5%) developed transiently elevated intraocular pressure that normalised by 6 months in all but one patient. No injection-or surgery-related complications were encountered.Conclusions Phacoemulsification with concurrent 4 mg ivTA injection appears to be a safe option for managing diabetics with cataract and CSMO. However, large-scaled randomised controlled trials are necessary for delineating the relative contributions of cataract removal and CMT reduction to visual improvement. Moreover, the transient effect on CMT may warrant further studies to determine optimal timing and dosage of further ivTA injections.

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Intravitreal triamcinolone for uveitic cystoid macular edema: an optical coherence tomography study

Cited by 409 publications

References 42 publications

Optical coherence tomography imaging in uveitis

Optical coherence tomography imaging in uveitis

Intravitreal triamcinolone acetonide for macular oedema owing to retinal vein occlusion

Phacoemulsification with intravitreal triamcinolone in patients with cataract and coexisting diabetic macular oedema: a 6-month prospective pilot study

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