Intravitreal Liposome-encapsulated Triofluorothymidine in a Rabbet Model

Prevention of Experimental Proliferative Vitreoretinopathy With a Biodegradable Intravitreal Implant for the Sustained Release of Fluorouracil

“…The therapeutic effect of the drug\ x=req-\ containing implant was associated with sustained intravitreal concentrations of fluorouracil between 1 and 13 mg/L for at least 14 days, and fluorouracil concentrations remained above 0.3 \g=m\g/mL for almost 21 …”

Intravitreal liposome-encapsulated drugs: A preliminary human report

“…In a preliminary study in our laboratory [9], intravitreally injected drug-free liposomes were found to be nontoxic by histopathological and electrophysiological studies. These may imply that liposomes, as a vehicle, are not only nontoxic but also can reduce the toxic side effects of encapsulated drugs.…”

“…This contributes to prevention of peak concentration, and maintains the therapeutic drug level for a longer period of time. Preliminary work in our laboratory [5,9,16,18] and by other investigators [2,20,22] has demonstrated that intravitreally administered liposome-encapsulated drugs have potential in effective drug delivery for various ocular diseases.…”

“…The choice of phospholipid employed for these experiments was made on the basis of previous experiments. The composition of PC/PG was employed because previous work with lipid vesicles has shown these vesicles to be relatively stable in buffer and in serum, and our work [5,9] and the work of others [2] have shown that liposomes prolong the lifetime of certain drugs in the vitreous. This composition is useful for encapsulating small molecular weight, water soluble drugs such as those employed here.…”

“…Repeated injection, however, can be accompanied by complications such as lens or retinal injury. To avoid these complications, efforts have been made to entrap drugs within liposomes [5,9,16,18,22]. These lipid vesicles release the drug slowly, thereby reducing the toxicity of drugs and maintaining desired drug concentrations for a long period of time.…”