Intravitreal injection of Penicillin in a case of incipient abscess of the vitreous following extracapsular cataract extraction. Perfect cure

Feigenbaum, Aryeh; Kornblüth, W.

doi:10.1159/000300284

Cited by 19 publications

(8 citation statements)

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“…However, intravitreal injections of steroids reach suitable intraocular concentrations avoiding the ocular barriers. 42 Intravitreal TA has been found to be suitable for refractory PCME treatment. 9,12 Nevertheless, to diminish ocular hazards related to intravitreal injections of TA and to preserve the benefits of using them in refractory PCME, it is necessary to develop alternative strategies for drug delivery.…”

Section: Discussionmentioning

confidence: 99%

Novel Triamcinolone Acetonide-Loaded Liposomes Topical Formulation for the Treatment of Cystoid Macular Edema After Cataract Surgery: A Pilot Study

Rosa

Navarro-Partida

Altamirano-Vallejo

et al. 2019

Journal of Ocular Pharmacology and Therapeutics

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Purpose: To report tolerability, safety, and efficacy of a topical triamcinolone acetonide-loaded liposomes formulation (TA-LF) in targeting the macular area in patients with refractory pseudophakic cystoid macular edema (PCME). Methods: For tolerability, safety and efficacy evaluation, 12 eyes of 12 patients with refractory PCME were exposed to one drop of TA-LF (TA at 0.2%) every 2 h for 90 days or until best-corrected visual acuity (BCVA) was achieved. Intraocular pressure (IOP), slit lamp examination, and central foveal thickness (CFT) were analyzed at every visit. Results: Patients with refractory PCME under TA-LF therapy showed a significant improvement in BVCA and CFT without significant IOP modification ( P = 0.94). On average CFT decreased to 206.75 ± 135.72 μm and BCVA improved to 20.08 ± 10.35 letters ( P < 0.0005). BCVA was achieved at 10.58 ± 6.70 weeks (range 2–18). TA-LF was well tolerated in all cases. Neither ocular surface abnormalities nor adverse events were recorded. Conclusion: TA-LF was well tolerated and improved BCVA and CFT on patients with refractory PCME.

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Section: Discussionmentioning

confidence: 99%

Novel Triamcinolone Acetonide-Loaded Liposomes Topical Formulation for the Treatment of Cystoid Macular Edema After Cataract Surgery: A Pilot Study

Rosa

Navarro-Partida

Altamirano-Vallejo

et al. 2019

Journal of Ocular Pharmacology and Therapeutics

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“…Intravitreal injections of steroids reach proper intraocular concentrations and avoid ocular barriers. 45 In fact, intravitreal TA has proven to be suitable for refractory PCME, as well as for the treatment of other vitreoretinal diseases. [46][47][48][49][50][51][52] Different reports using intravitreal triamcinolone acetonide (IVTA) have shown high efficacy with significant improvement of VA and a substantial reduction in macular thickness in patients with refractory PCME.…”

Section: Triamcinolone Acetonide-loaded Liposomes After Flacsmentioning

confidence: 99%

Novel Triamcinolone Acetonide-Loaded Liposomal Topical Formulation Improves Contrast Sensitivity Outcome After Femtosecond Laser-Assisted Cataract Surgery

Rosa

Navarro-Partida

Altamirano-Vallejo

et al. 2019

Journal of Ocular Pharmacology and Therapeutics

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Purpose: To assess visual results, macular modifications, and the incidence of clinically significant macular edema (CSME) in patients using a topical triamcinolone acetonide-loaded liposomal formulation (TA-LF) after femtosecond laser-assisted cataract surgery (FLACS). Methods: Fifty-six eyes after FLACS were selected. Twenty-eight eyes in the combined therapy group (P + N) were treated with prednisolone 1% and nepafenac 0.1% for 21 days postoperatively, whereas 28 eyes in the TA-LF group received a liposomal formulation containing 2 mg/mL of TA (0.2%) for the same period of time. Follow-up visits at 1 day, 6 weeks, and 12 weeks after surgery consisted of visual acuity, contrast sensitivity (CS), central foveal thickness (CFT), total macular volume (TMV) measurements, and the detection of CSME. Results: CS improved in the TA-LF group (basal value: 1.087-0.339 vs. 1.276-0.147 at week 12, P = 0.0346), whereas in the P + N group, CS was not different from the baseline (basal value: 1.130-0.331 vs. 1.274-0.133 at week 12, P = 0.1276). There were similar increases in postoperative CFT and TMV in both groups. CFT and TMV significantly correlate with CS only in the TA-LF group. The r 2 for CFT and CS was 0.1963 (P = 0.0206), whereas the r 2 for TMV and CS was 0.3615 (P = 0.0007) at 12 weeks. No difference was observed in the incidence of CSME between the groups. Conclusion: TA-LF is associated with better CS outcomes compared to combined therapy after FLACS.

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“…Although oral or topical corticosteroids routes of administration could be safer than IVTs, these have limited effectiveness for vitreoretinal disorders. Due to the blood-retinal barriers, these routes scarcely reach the posterior segment of the eye [14]. Therefore, to diminish the ocular risks associated with intravitreal injections, different topical ap-proaches have been developed to deliver therapeutic concentration of TA into the vitreous cavity [15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Safety and Tolerability of Topical Ophthalmic Triamcinolone Acetonide-loaded Liposomes Formulation and Evaluation of Its Biologic Activity in Patients with Diabetic Macular Edema

Navarro-Partida¹,

Altamirano-Vallejo²,

Rosa³

et al. 2021

Preprint

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Intravitreal injections (IVTs) of corticosteroids as triamcinolone acetonide (TA) are frequently used for the treatment of many vitreous and retinal disorders. However, IVTs are related to severe ocular complications. Lately, a topical ophthalmic TA loaded liposomes formulation (TALF) was designed to transport TA into the posterior segment of the eye when instilled in the ocular surface. To evaluate the safety, tolerability, and biologic activity of TALF, an animal study and a phase I clinical assay was performed. Moreover, four patients with diabetic macular edema (DME) were treated with TALF in order to explore the biologic activity of the formulation. No inflammation, lens opacity, swelling or intraocular pressure rising were recorded after the instillation of TALF in any of the animal or clinical study. Mainly, mild and transient adverse events such as dry eye (30%) and burning (30%) were reported. TALF improves significantly visual acuity and diminishes central foveal thickness in patients with DME. The current data demonstrate the safety, tolerability, and biologic activity of TALF. It seems that TALF can be used topically to treat vitreous and retinal diseases that respond to TA such as DME, avoiding the use of corticosteroids IVTs and its associated hazards.

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Intravitreal injection of Penicillin in a case of incipient abscess of the vitreous following extracapsular cataract extraction. Perfect cure

Cited by 19 publications

References 0 publications

Novel Triamcinolone Acetonide-Loaded Liposomes Topical Formulation for the Treatment of Cystoid Macular Edema After Cataract Surgery: A Pilot Study

Novel Triamcinolone Acetonide-Loaded Liposomes Topical Formulation for the Treatment of Cystoid Macular Edema After Cataract Surgery: A Pilot Study

Novel Triamcinolone Acetonide-Loaded Liposomal Topical Formulation Improves Contrast Sensitivity Outcome After Femtosecond Laser-Assisted Cataract Surgery

Safety and Tolerability of Topical Ophthalmic Triamcinolone Acetonide-loaded Liposomes Formulation and Evaluation of Its Biologic Activity in Patients with Diabetic Macular Edema

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