Intravitreal Injection Anesthesia—Comparison of Different Topical Agents: A Prospective Randomized Controlled Trial

Yau, Gary L.; Jackman, Christopher S.; Hooper, Philip L.; Sheidow, Tom G.

doi:10.1016/j.ajo.2010.08.031

Cited by 40 publications

(44 citation statements)

References 18 publications

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“…Additionally, in a recently published study, Sanabria et al, concluded that topical tetracaine and lidocaine provide similar anesthesia before intravitreal injections and that topical diclofenac does not seem to reduce pain scores after them [5]. In agreement with this conclusion, Yau et al, showed that there was no difference in patient pain experience between the 3 (tetracaine, lidocaine and cocaine) anesthetic options tested [7]. Similarly, Blaha et al, compared lidocaine pledget, topical proparacaine, subconjunctival lidocaine and topical tetracaine without obtaining any significant difference in patient pain experience [8].…”

Section: Discussionsupporting

confidence: 71%

Topical Anesthesia with Ropivacaine and Proparacaine for Intravitreal Injection Procedures

Klados¹

2015

OCR

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Section: Discussionsupporting

confidence: 71%

Topical Anesthesia with Ropivacaine and Proparacaine for Intravitreal Injection Procedures

Klados¹

2015

OCR

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“…Blaha et al showed that the overall pain experience is similar, regardless of method used: proparacaine topical eyedrops, tetracaine topical eyedrops, lidocaine pledget, or subconjunctival lidocaine (4). Yau et al also showed no difference between topical anesthetic agents for intravitreal injection (5). Our study demonstrated that pain associated with intravitreal injection is mild and may be associated with certain factors, such as gender, age, and perceived visual improvement.…”

Section: Shortening Ocular Pain Duration Following Intravitreal Injecmentioning

confidence: 63%

Shortening Ocular Pain Duration following Intravitreal Injections

Rifkin

Schaal

2012

European Journal of Ophthalmology

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Purpose. To determine ocular pain duration after routine in-office intravitreal injection and to determine whether topical eyedrops are beneficial in increasing patient comfort. Methods. Forty injection-naïve patients receiving routine intravitreal injections of bevacizumab for age-related macular degeneration were randomized into 3 groups: group 1 (control, no drops), group 2 (generic artificial tears), and group 3 (ketorolac tromethamine 0.4% eyedrops). Those who received topical medications were given a Visual Analog Pain score survey and asked to record their pain on a scale from 0 (no distress) to 10 (unbearable distress) daily until a score of 0 was achieved, at which point they were instructed to discontinue use of their given drops. Self-reported pain scores were assessed. Results. Pain after routine intravitreal injection lasts on average between 3 and 7 days. Patients receiving topical ketorolac eyedrops reported the fewest average number of pain days (2.25±1.22) vs patients receiving artificial tears (3.54±1.13) or those who received no postprocedure eyedrops (5.13±1.25); p<0.05. At most, patients receiving ketorolac eyedrops reported 3 days of recordable pain. Those who received artificial tears reported at most 5 days of recordable pain, and patients who did not receive any postprocedure eyedrops reported at most 7 days of recordable pain. Conclusions. Pain after intravitreal injection is generally mild, may be reduced by postinjection topical ketorolac eyedrops, and lasts less than 1 week.

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“…Their findings are in agreement with a previous study by Yau et al that prospectively compared the effectiveness of three topical agents used for intravitreal injections including 0.5% tetracaine hydrochloride drops and a 4% lidocaine pledget, 0.5% tetracaine hydrochloride drops alone, or 4% cocaine drops alone. No statistical or clinical difference in patient pain experienced was demonstrated between the three anesthetic options [8]. A similar study conducted by Blaha et al prospectively compared the effectiveness of 0.5% proparacaine, 0.5% tetracaine, 4% lidocaine pledget, and subconjunctival injection of 2% lidocaine for intravitreal injection in 24 patients.…”

Section: Articlementioning

confidence: 96%