Intravital two-photon microscopy of the native mouse thymus
Negar Seyedhassantehrani,
Christian S. Burns,
Ruth Verrinder
et al.
Abstract:The thymus, a key organ in the adaptive immune system, is sensitive to a variety of insults including cytotoxic preconditioning, which leads to atrophy, compression of the blood vascular system, and alterations in hemodynamics. Although the thymus has innate regenerative capabilities, the production of T cells relies on the trafficking of lymphoid progenitors from the bone marrow through the altered thymic blood vascular system. Our understanding of thymic blood vascular hemodynamics is limited due to technica… Show more
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