Intravital Microscopy

Chamma, Émilie; Daradich, Amy; Côté, Daniel; Yun, Seok Hyun

doi:10.1016/b978-0-12-386456-7.07607-3

Cited by 2 publications

(1 citation statement)

References 22 publications

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“…Technological development to assess microcirculation during critical illness is one of the best examples of the way that translational research has impacted the field of critical care medicine [11]. Indeed, for a long time, the evaluation of human microcirculation has been restricted to experimental settings and constrained clinical scenarios [12].…”

Section: Assessment Of Microcirculation At the Bedsidementioning

confidence: 99%

Devices for assessing microcirculation

Edul

Gutiérrez

2023

Current Opinion in Critical Care

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Purpose of reviewDevices for assessing microcirculation at the bedside have been a technological breakthrough in the critical care field. Thanks to this technology, a large body of scientific evidence has highlighted the relevance of microcirculatory disruptions during critical illness. The goal of this review is to analyze the current knowledge concerning microcirculation monitoring, mainly focused on clinically available devices. Recent findingsNew evidence in oxygenation monitoring, advances in hand-held vital microscopes, and improvements in laser-based techniques ensure the possibility of detecting poor resuscitation, testing vascular reactivity, and assessing the effect of therapy during shock and resuscitation. SummaryCurrently, there are several methods for microcirculatory monitoring. To properly apply and correctly interpret the information they provide, clinicians should know the fundamental principles and the strengths and weaknesses of the clinically available devices.

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Section: Assessment Of Microcirculation At the Bedsidementioning

confidence: 99%

Devices for assessing microcirculation

Edul

Gutiérrez

2023

Current Opinion in Critical Care

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Epigenetic basis of diabetic vasculopathy

et al. 2022

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Type 2 diabetes mellitus (T2DM) causes peripheral vascular disease because of which several blood-borne factors, including vital nutrients fail to reach the affected tissue. Tissue epigenome is sensitive to chronic hyperglycemia and is known to cause pathogenesis of micro- and macrovascular complications. These vascular complications of T2DM may perpetuate the onset of organ dysfunction. The burden of diabetes is primarily because of a wide range of complications of which nonhealing diabetic ulcers represent a major component. Thus, it is imperative that current research help recognize more effective methods for the diagnosis and management of early vascular injuries. This review addresses the significance of epigenetic processes such as DNA methylation and histone modifications in the evolution of macrovascular and microvascular complications of T2DM.

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Intravital Microscopy

Cited by 2 publications

References 22 publications

Devices for assessing microcirculation

Devices for assessing microcirculation

Epigenetic basis of diabetic vasculopathy

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