Abstract:After tick transmission, the spirochete, Borrelia burgdorferi (Bb), remains at the skin inoculation site for up to 48 hours before spreading and causing Lyme disease. Bb surface agonists should elicit potent inflammation and clearance in skin. However, the ID50 is <50 Bb, indicating efficient immunoevasion and suggesting that traditional in vitro models are inadequate for accurately characterizing Bb pathogenesis (i.e. most models display efficient Bb clearance by phagocytes). Thus, we have devised a co… Show more
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