Intravesical Therapy of Bladder Cancer: An lmmunotherapy Success Story

Morales, Alvaro

doi:10.1111/j.1442-2042.1996.tb00548.x

Cited by 8 publications

(1 citation statement)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is because inflammation provides immunization against a broad range of infections. Cancer immunotherapy considers immunostimulation to be a critical step in preventing tumor recurrence [51].…”

Section: Immunomodulatory Effectsmentioning

confidence: 99%

A Review on Fucoidan Structure, Extraction Techniques, and Its Role as an Immunomodulatory Agent

et al. 2022

View full text Add to dashboard Cite

Functional ingredients for human health have recently become the focus of research. One such potentially versatile therapeutic component is fucose-containing sulfated polysaccharides (FCSPs), referred to as fucoidans. The exploitation of marine brown algae provides a rich source of FCSPs because of their role as a structural component of the cell wall. Fucoidans are characterized by a sulfated fucose backbone. However, the structural characterization of FCSPs is impeded by their structural diversity, molecular weight, and complexity. The extraction and purification conditions significantly influence the yield and structural alterations. Inflammation is the preliminary response to potentially injurious inducements, and it is of the utmost importance for modulation in the proper direction. Improper manipulation and/or continuous stimuli could have detrimental effects in the long run. The web of immune responses mediated through multiple modulatory/cell signaling components can be addressed through functional ingredients, benefiting patients with no side effects. In this review, we attempted to address the involvement of FCSPs in the stimulation/downregulation of immune response cell signaling. The structural complexity and its foremost influential factor, extraction techniques, have also attracted attention, with concise details on the structural implications of bioactivity.

show abstract

Section: Immunomodulatory Effectsmentioning

confidence: 99%

A Review on Fucoidan Structure, Extraction Techniques, and Its Role as an Immunomodulatory Agent

et al. 2022

View full text Add to dashboard Cite

show abstract

BCG

Mizutani¹

2016

Immunotherapy of Cancer

View full text Add to dashboard Cite

The efficacy of Bacillus Calmette-Guerin instillation therapy of the upper urinary tract for carcinoma in situ

Hattori

Kimura

Horiuchi

et al. 1999

International Journal of Clinical Oncology

View full text Add to dashboard Cite

Background. Treatment of carcinoma in situ (CIS) of the upper urinary tract is still difficult. In this study, we assessed the efficacy and safety results of Bacillus Calmette-Guerin (BCG) instillation therapy for CIS of the upper urinary tract. Methods. Thirteen renal units with CIS in eight patients 60-77 years old (median, 68 years) were treated with BCG. BCG (Tokyo 172 strain) was instilled at a dose of 160 mg into each renal unit once a week for 6 consecutive weeks via nephrostomy. The follow-up period ranged from 7 to 63 months (median, 26 months). Results. Of 13 renal units in eight patients, 12 units (92.3%) in eight patients became negative by cytology. Only 1 renal unit showed recurrence. The duration of the response ranged from 7 to 63 months (median, 25 months). Few side effects were observed after BCG instillation. Fever was most frequent (6/8, 75%), followed by symptoms of irritation such as frequency (5/8, 62.5%). Conclusion. BCG instillation therapy is safe and effective for CIS of the upper urinary tract. It can be used as a firstline therapy instead of any surgical option.

show abstract

Intravesical Therapy of Bladder Cancer: An lmmunotherapy Success Story

Cited by 8 publications

References 27 publications

A Review on Fucoidan Structure, Extraction Techniques, and Its Role as an Immunomodulatory Agent

A Review on Fucoidan Structure, Extraction Techniques, and Its Role as an Immunomodulatory Agent

BCG

The efficacy of Bacillus Calmette-Guerin instillation therapy of the upper urinary tract for carcinoma in situ

Contact Info

Product

Resources

About