Intravesical injection of botulinum toxin type a may be an effective treatment option for autonomic dysreflexia in patients with high-level spinal cord injury

Huang, Maping; Zheng, Heyi; Huang, Tianhai; Yang, Xiaoyi; Liu, Qiuling; Li, Qingqing; Tang, Peng; Xie, Keqin; Chen, Hui

doi:10.1080/10790268.2022.2135230

Cited by 2 publications

(2 citation statements)

References 32 publications

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“…Currently, only off-label use of Botox ® has been evaluated in the treatment of AD [ 113 , 116 , 133 , 134 , 135 ].…”

Section: The Use Of Botulinum Toxin In Conditions With Autonomic Dysf...mentioning

confidence: 99%

“…Intravesical injections of 200 U of Botox ® diminished bladder-related AD events during UDS [ 113 , 116 ]. This was reported by reduced systolic blood pressure elevations and reduced incidence of self-reported AD symptoms, both during filling and at cystometric capacity, one month after injection [ 113 , 133 , 134 , 135 ]. Furthermore, Botox ® minimizes the reflexive vagal responses associated with bladder filling during UDS, as evidenced by changes in heart rate variability (HRV) [ 133 ].…”

Section: The Use Of Botulinum Toxin In Conditions With Autonomic Dysf...mentioning

confidence: 99%

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From Toxin to Treatment: A Narrative Review on the Use of Botulinum Toxin for Autonomic Dysfunction

Rempel,

Malik,

Shackleton

et al. 2024

Toxins

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Since its regulatory approval over a half-century ago, botulinum toxin has evolved from one of the most potent neurotoxins known to becoming routinely adopted in clinical practice. Botulinum toxin, a highly potent neurotoxin produced by Clostridium botulinum, can cause botulism illness, characterized by widespread muscle weakness due to inhibition of acetylcholine transmission at neuromuscular junctions. The observation of botulinum toxin’s anticholinergic properties led to the investigation of its potential benefits for conditions with an underlying etiology of cholinergic transmission, including autonomic nervous system dysfunction. These conditions range from disorders of the integument to gastrointestinal and urinary systems. Several formulations of botulinum toxin have been developed and tested over time, significantly increasing the availability of this treatment for appropriate clinical use. Despite the accelerated and expanded use of botulinum toxin, there lacks an updated comprehensive review on its therapeutic use, particularly to treat autonomic dysfunction. This narrative review provides an overview of the effect of botulinum toxin in the treatment of autonomic dysfunction and summarizes the different formulations and dosages most widely studied, while highlighting reported outcomes and the occurrence of any adverse events.

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“…Currently, only off-label use of Botox ® has been evaluated in the treatment of AD [ 113 , 116 , 133 , 134 , 135 ].…”

Section: The Use Of Botulinum Toxin In Conditions With Autonomic Dysf...mentioning

confidence: 99%

Section: The Use Of Botulinum Toxin In Conditions With Autonomic Dysf...mentioning

confidence: 99%

From Toxin to Treatment: A Narrative Review on the Use of Botulinum Toxin for Autonomic Dysfunction

Rempel,

Malik,

Shackleton

et al. 2024

Toxins

View full text Add to dashboard Cite

show abstract

Autonomic Dysreflexia (AD): A serious, rather underestimated condition, a review based on Workshop 11, held on ICS Vienna 2022

Konstantinidis¹,

Agrò

Panicker

et al. 2023

Continence

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Intravesical injection of botulinum toxin type a may be an effective treatment option for autonomic dysreflexia in patients with high-level spinal cord injury

Cited by 2 publications

References 32 publications

From Toxin to Treatment: A Narrative Review on the Use of Botulinum Toxin for Autonomic Dysfunction

From Toxin to Treatment: A Narrative Review on the Use of Botulinum Toxin for Autonomic Dysfunction

Autonomic Dysreflexia (AD): A serious, rather underestimated condition, a review based on Workshop 11, held on ICS Vienna 2022

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