Intravesical Chemotherapy: Primary in Vitro Culture of MGH-UI Bladder Tumor Spheroids as a Three Dimensional Chemosensitivity Test System

Knüchel, Ruth; Hofstädter, Ferdinand; McCarthy, David; Jenkins, Wendy E.A.; Masters, Jrw

doi:10.1016/s0022-5347(17)75821-1

Cited by 1 publication

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“…Было также обнаружено, что из-за рн-градиентов, существующих внутри сфероидов, клетки некротической зоны могут быть защищены от цитотоксического действия слабокислых препаратов, таких как митоксантроны и антрациклины, тогда как действие слабощелочных препаратов, таких как хлорамбуцил и митомицин С, усиливается [36,39,69].…”

Section: применение метода культивирования сфероидовunclassified

The Creating of Three-Dimensional Cellular Models to Solve Theoretical and Practical Problems of Modern Oncology

Prosekina¹,

Данилова²,

Nekhaeva³

et al. 2019

Problems in oncology

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A tumor is a multicomponent, spatially difficult organi-zated system, which is characterized by individual characteristics for each patient. In vitro cell model creating that is close in structure and properties to the natural tumor system will promotes to solving such practical and theoretical problems of modern oncology as identifying the biological patterns of tumor growth, the behavior of cells of the immune system, testing potential antitumor drugs, determining the effectiveness of methods chemo-, radio-, photodynamic, targeted and immunotherapy. Such model can be three-dimensional cellular structures - spheroids (tumoroids). The review presents data about the features of three-dimensional cell modeling, the characteristics of existing 3D models and their application in experimental and clinical studies.

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Section: применение метода культивирования сфероидовunclassified