Intravesical Capsaicin Versus Resiniferatoxin for the Treatment of Detrusor Hyperreflexia in Spinal Cord Injured Patients:: A Double-Blind, Randomized, Controlled Study

Sèze, M. de; Wiart, L.; Sèze, Mathieu Panchoa de; Soyeur, Luc; Dosque, Jean-Pierre; Blajezewski, Sylvie; Moore, Nicholas; Brochet, Bruno; Mazaux, Jean-Michel; Barat, M.; Joseph, Pierre-Alain

doi:10.1097/01.ju.0000100385.93801.d4

Cited by 92 publications

(78 citation statements)

References 19 publications

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“…In a recent capsaicin versus resiniferatoxin (RTX) controlled study, we reported that glucidic capsaicin was as e⁄-cient and safe as 10% ethanol RTX on NDO in 39 SCI patients [de Se' ze et al, 2004]. The present multicenter study, which includes several neurourological centers which are not particularly involved in vanilloid development, strengthened the demonstration of the feasibility and validity of this treatment procedure.…”

Section: Discussionsupporting

confidence: 63%

Intravesical glucidic capsaicin versus glucidic solvent in neurogenic detrusor overactivity: A double blind controlled randomized study

Sèze¹,

Gallien

Denys

et al. 2006

Neurourology and Urodynamics

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Section: Discussionsupporting

confidence: 63%

Intravesical glucidic capsaicin versus glucidic solvent in neurogenic detrusor overactivity: A double blind controlled randomized study

Sèze¹,

Gallien

Denys

et al. 2006

Neurourology and Urodynamics

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“…14 Intravesical administration of capsaicin or resiniferatoxin might result in unwanted side effects such as suprapubic burning sensation, hematuria, urine leakage, a hot flush, and/or signs of AD. 15 BoNT-A injection into bladder detrusor muscle could use but it is expansive and it need the another procedure, cystoscopy. And sacral rhizotomy could also be used, but these methods are invasive and could incur complications.…”

Section: Discussionmentioning

confidence: 99%

The effect of semiconditional dorsal penile nerve electrical stimulation on capacity and compliance of the bladder with deformity in spinal cord injury patients: a pilot study

et al. 2012

Spinal Cord

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Study design: Bladder capacity, bladder compliance, the volume of the first overactive contraction, maximal volume during cystometry (CMG) and the vesicoureteral reflux, bladder wall deformity before and after semiconditional stimulation on DPN. Objectives: To evaluate the effect of the semiconditional electrical stimulation on dorsal penile nerve (DPN) to improve the complicated bladder function in male with spinal cord injury (SCI). Setting: Semiconditional stimulation system and urodynamic laboratory in a university hospital. Participants: Six men (age, 33-59 years) with SCI incurred from 38 to 156 months before this study. Intervention: semiconditional stimulation parameters were set during CMG and semiconditional stimulation on DPN by surface electrodes via Empi Focus stimulator was applied from 14 to 28 days, at home. Parameters about bladder function were measured before and after stimulation applied. Result: All parameters for bladder after semiconditional stimulation were increased. Also, the vesicoureteral reflux and bladder wall deformity was improved in five of six patients. Conclusion: Semiconditional electrical stimulation on DPN effectively suppresses neurogenic detrusor overactivity and distend the bladder physiologically in the SCI patient with a complicated bladder. The bladder capacity and compliance as well as the bladder wall deformity were improved as a result of this treatment. Keywords: spinal cord injuries; electric stimulation therapy/methods; neurogenic detrusor overactivity; neurogenic lower urinary tract symptom; urodynamic studies INTRODUCTIONThe goal of neurogenic bladder management in patients with spinal cord injury (SCI) is to achieve low-pressure urinary storage in bladders with continence, efficient and complete emptying with normal pressures, and preservation of kidney function, as well as preventing urinary tract infections. A poorly compliant bladder distends with high intravesical pressure at relatively low volumes and may lead to vesicoureteral reflux. These problems put the upper urinary tract at an even greater risk for deterioration. 1 Following the suprasacral SCI, the pontine micturition center cannot control bladder function and sphincter activity. Thus, after suprasacral SCI, detrusor overactivity, urethral smooth muscle synergia, and striated urethral muscle dyssynergia can occur. 2 The neurogenic detrusor overactivity correlates closely with low compliance and bladder wall deformity. 3 Neurologic injury and denervation could increase the collagen content in the bladder wall. The increasing collagen content decreases the bladder wall's viscoelasticity and results in lower bladder compliance. 4 Several methods for the control of the neurogenic detrusor overactivity have been recommended. Medications such as detrusor muscle relaxant are prescribed for patients with neurogenic detrusor overactivity in order to increase bladder capacity and compliance. 5 Intravesical administration of capsaicin or resiniferatoxin achieves similar results. However, these above-mentione...

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“…In addition, RTX did not evoke the same irritating side effects as capsaicin. 98 de Sèze et al 99 however, did not observe any differences in efficacy and tolerance between capsaicin dissolved in glucidic solvent and RTX dissolved in 10% ethanol. They suggest that differences between the effect of capsaicin and RTX in previous studies are strongly influenced by the vanilloid solute.…”

Section: Trpv1 As Therapeutic Targetmentioning

confidence: 91%

On the origin of bladder sensing: Tr(i)ps in urology

Everaerts

Gevaert

Nilius

et al. 2007

Neurourology and Urodynamics

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The mammalian TRP family consists of 28 channels that can be subdivided into 6 different classes: TRPV (vanilloid), TRPC (canonical), TRPM (Melastatin), TRPP (Polycystin), TRPML (Mucolipin), and TRPA (Ankyrin). TRP channels are activated by a diversity of physical (voltage, heat, cold, mechanical stress) or chemical (pH, osmolality) stimuli and by binding of specific ligands, enabling them to act as multifunctional sensors at the cellular level. Currently, a lot of scientific research is devoted to these channels and their role in sensing mechanisms throughout the body. In urology, there's a growing conviction that disturbances in afferent (sensory) mechanisms are highly important in the pathogenesis of functional problems. Therefore, the TRP family forms an interesting new target to focus on. In this review we attempt to summarize the existing knowledge about TRP channels in the urogenital tract. So far, TRPV1, TRPV2, TRPV4, TRPM8, and TRPA1 have been described in different parts of the urogenital tract. Although only TRPV1 (the vanilloid receptor) has been extensively studied so far, more evidence is slowly accumulating about the role of other TRP channels in the (patho)physiology of the urogenital tract.

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Intravesical Capsaicin Versus Resiniferatoxin for the Treatment of Detrusor Hyperreflexia in Spinal Cord Injured Patients:: A Double-Blind, Randomized, Controlled Study

Abstract: Our results strongly argue for the importance of accounting for the role of vanilloid solute when interpreting the efficacy and tolerance of vesical vanilloid instillation in detrusor hyperreflexia cases. They suggest that a glucidic solute is a valuable solvent for vanilloid instillation.

Cited by 92 publications

References 19 publications

Intravesical glucidic capsaicin versus glucidic solvent in neurogenic detrusor overactivity: A double blind controlled randomized study

Intravesical glucidic capsaicin versus glucidic solvent in neurogenic detrusor overactivity: A double blind controlled randomized study

The effect of semiconditional dorsal penile nerve electrical stimulation on capacity and compliance of the bladder with deformity in spinal cord injury patients: a pilot study

On the origin of bladder sensing: Tr(i)ps in urology

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