Intravesical Capsaicin Therapy: A Review

Ozawa, Hideo; Jung, Suk Young; Fraser, Olivia; Rivas, David A.; Chancellor, B.

doi:10.1080/10790268.1999.11719556

Cited by 8 publications

(3 citation statements)

References 3 publications

(3 reference statements)

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“…26), urothelium, nerve endings, and detrusor muscle, where they presumably function as sensors of stretch and chemical irritation (reviewed in Avelino and Cruz, 2006;Everaerts et al, 2008;Skryma et al, 2011;Avelino et al, 2013;Birder and Andersson, 2013). Intravesical administration of TRPV1 agonists (capsaicin and RTX) has been in use in the management of the overactive bladder for many years on a largely empirical basis (reviewed in Ozawa et al, 1999;Szallasi and Fowler, 2002). The recent recognition of disease state-related changes in TRP channel expression has given new impetus to investigate the roles of these channels in normal bladder function and dysfunction.…”

Section: Transient Receptor Potential Channels As Therapeutic Targmentioning

confidence: 99%

Transient Receptor Potential Channels as Drug Targets: From the Science of Basic Research to the Art of Medicine

2014

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Section: Transient Receptor Potential Channels As Therapeutic Targmentioning

confidence: 99%

Transient Receptor Potential Channels as Drug Targets: From the Science of Basic Research to the Art of Medicine

2014

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“…Indeed, low-concentration capsaicin creams probably act as counterirritants rather than true desensitizing agents. By contrast, intravesical administration of capsaicin proved beneficial in patients with overactive bladder [15][16][17]. Intranasal capsaicin was also tried to relieve the symptoms of vasomotor rhinitis [18], migraine [19], and cluster headache [20].…”

Section: Introduction a Brief Historical Over-viewmentioning

confidence: 94%

Therapeutic Targeting of TRPV1 by Resiniferatoxin, from Preclinical Studies to Clinical Trials

Kissin

Szállaśi²

2011

CTMC

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In primary sensory neurons, the capsaicin receptor TRPV1 functions as a molecular integrator for a broad range of seemingly unrelated chemical and physical noxious stimuli, including heat and altered pH. Indeed, TRPV1 is thought to be a major transducer of the thermal hyperalgesia that follows inflammation and tissue injury as this response is impaired in TRPV1-deficient mice. Following the molecular cloning of TRPV1 in 1997, over a dozen companies embarked on efforts to find clinically useful TRPV1 antagonists, but side-effects and limited efficacy have thus far prevented any compounds from progressing beyond phase II. This has rekindled interest in desensitization of nociceptive neurons to TRPV1 agonists (e.g. capsaicin and its ultrapotent analog resiniferatoxin) as an alternative pharmacological approach to block pain in the periphery where it is generated. The clinical value of capsaicin is, however, limited by its unfavorable irritancy to desensitization ratio. In animal experiments, resiniferatoxin treatment is a powerful approach to achieve long-lasting analgesia. In patients with overactive bladder, intravesical resiniferatoxin improves bladder function (or even restores continence) without significant irritancy and/or toxicity. In this review, we argue that resiniferatoxin is an attractive alternative to capsaicin in that it achieves lasting desensitization without the side effects that complicate capsaicin therapy.

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“…The benefits of intravesicular instillation are seen after the first 2 weeks with symptomatic improvement in 60%-80% of patients and a 2-to 3fold increase in bladder capacity and improved urodynamic profiles with lower pressures overall in 70%-100% of patients. 36 The use of capsaicin is often avoided in patients prone to autonomic dysreflexia, but otherwise it appears quite safe. Its efficacy lasts between 6 months and 3 years with good response to repeat bladder instillations.…”

Section: Urinary Incontinencementioning

confidence: 99%