Intravesical botulinum type-A toxin (Dysport®) in the treatment of idiopathic detrusor overactivity in children

Blackburn, Simon; Jones, Christine E; Bedoya, Santiago Manrique; Steinbrecher, Henrik; Malone, P.S.; Griffin, Stephen

doi:10.1016/j.jpurol.2012.08.011

Cited by 28 publications

(32 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…There is currently limited literature on the use of BtA for the treatment of IOAB in the paediatric population [2,8e11]. The overall initial complete symptomatic success rate in this study is 28%, and this is lower than that found in the studies by Lahdes-Vasama et al [8] (38%), Marte et al [9] (38%), Blackburn et al [10] (44%) and Hoebeke et al [2] (60%). Night-time continence was not used as an outcome measure by Hoebeke et al [2]; therefore, comparison is difficult as this study defines complete success as dryness during both the day and the night.…”

Section: Discussioncontrasting

confidence: 52%

See 1 more Smart Citation

Onabotulinum toxin A in children with refractory idiopathic overactive bladder: medium-term outcomes

Ingham

Angotti

Lewis

et al. 2019

Journal of Pediatric Urology

View full text Add to dashboard Cite

Section: Discussioncontrasting

confidence: 52%

“…McDowell et al [11] and Blackburn et al [10] used Dysportâ in their studies. As the doses in units of Dysportâ and Botoxâ are not equivalent, comparison of the effec-tiveness of doses from these articles are difficult.…”

Section: Discussionmentioning

confidence: 99%

Onabotulinum toxin A in children with refractory idiopathic overactive bladder: medium-term outcomes

Ingham

Angotti

Lewis

et al. 2019

Journal of Pediatric Urology

View full text Add to dashboard Cite

“…CHILDHOOD ENURESIS may be refractory to conventional treatment, and those with continued symptoms may need treatments, including intravesical botulinum toxin (2,8). Urodynamic observations include poor compliance, detrusor overactivity, and outflow abnormalities.…”

mentioning

confidence: 99%

Functional properties and connective tissue content of pediatric human detrusor muscle

Johal

Wood

Wagg

et al. 2014

American Journal of Physiology-Renal Physiology

View full text Add to dashboard Cite

The functional properties of human pediatric detrusor smooth muscle are poorly described, in contrast to those of adult tissue. Characterization is necessary for more informed management options of bladder dysfunction in children. We therefore compared the histological, contractile, intracellular Ca2+ concentration responses and biomechanical properties of detrusor biopsy samples from pediatric (3-48 mo) and adults (40-60 yr) patients who had functionally normal bladders and were undergoing open surgery. The smooth muscle fraction of biopsies was isolated to measure proportions of smooth muscle and connective tissue (van Gieson stain); in muscle strips, isometric tension to contractile agonists or electrical field stimulation and their passive biomechanical properties; in isolated myocytes, intracellular Ca2+ concentration responses to agonists. Pediatric detrusor tissue compared with adult tissue showed several differences: a smaller smooth muscle-to-connective tissue ratio, similar contractures to carbachol or α,β-methylene ATP when corrected for smooth muscle content, and similar intracellular Ca2+ transients to carbachol, α,β-methylene ATP, raised K+ concentration or caffeine, but smaller nerve-mediated contractions and greater passive stiffness with slower stress relaxation. In particular, there were significant atropine-resistant nerve-mediated contractions in pediatric samples. Detrusor smooth muscle from functionally normal pediatric human bladders is less contractile than that from adult bladders and exhibits greater passive stiffness. Reduced bladder contractile function is not due to reduced smooth muscle contractility but to greater connective tissue deposition and to functional denervation. Significant atropine resistance in pediatric detrusor, unlike in adult tissue, demonstrates a different profile of functional neurotransmitter activation. These data have implications for the management of pediatric bladder function by therapeutic approaches.

show abstract

“…Two small retrospective studies focused on the role of aboBNTa in children with NDO. Although, aboBNTa may be a potential therapeutic option for the management of NDO in children resistant to the usual treatments, these studies did not demonstrate a correlation between dose or functional bladder capacity and resolution of incontinence …”

Section: Discussionmentioning

confidence: 78%

“…Although, aboBNTa may be a potential therapeutic option for the management of NDO in children resistant to the usual treatments, these studies did not demonstrate a correlation between dose or functional bladder capacity and resolution of incontinence. 47,48 Many randomized clinical trials (RCTs) and several review articles support the efficacy and safety of onaBNTa in treating NDO. 2,10 Furthermore, literature has clearly shown the persistence of the therapeutic effect with repeated treatments during the time.…”

Section: Discussionmentioning

confidence: 99%

Adolescence transitional care in neurogenic detrusor overactivity and the use of OnabotulinumtoxinA: A clinical algorithm from an Italian consensus statement

Palleschi

Mosiello

Iacovelli

et al. 2017

Neurourology and Urodynamics

View full text Add to dashboard Cite

This manuscript represents the first report on the onaBNTa in adolescents. Young adults should be treated as a distinct sub-population in policy, planning, programming, and research, as strongly sustained by national public health care. This consensus and the algorithm could support multidisciplinary communication, reduce the extent of variations in clinical practice and optimize clinical decision making.

show abstract

Intravesical botulinum type-A toxin (Dysport®) in the treatment of idiopathic detrusor overactivity in children

Cited by 28 publications

References 12 publications

Onabotulinum toxin A in children with refractory idiopathic overactive bladder: medium-term outcomes

Onabotulinum toxin A in children with refractory idiopathic overactive bladder: medium-term outcomes

Functional properties and connective tissue content of pediatric human detrusor muscle

Adolescence transitional care in neurogenic detrusor overactivity and the use of OnabotulinumtoxinA: A clinical algorithm from an Italian consensus statement

Contact Info

Product

Resources

About