Intraventricular Tuberculoma in a Child: A Rare Location

Sachdeva, Deepashu; Bishnoi, Ishu; Jagetia, Anita; Rathore, Lavlesh; Agarwal, Atul; Batra, Vineeta Vijay; Kaur, Amandeep

doi:10.1159/000450756

Cited by 8 publications

(13 citation statements)

References 11 publications

(16 reference statements)

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“…In the event of ventricular involvement, gelatinous exudates have been reported on the choroid plexus, leading to ependymitis and hydrocephalus developing due to the formation of adhesions within the ventricular system. 15 Minimal evidence is present regarding outcomes after resection. In 2020, Vemula et al proposed a set of criteria that warranted surgical therapy.…”

Section: Discussionmentioning

confidence: 99%

Intracranial tuberculoma: a rare complication of extrapulmonary tuberculosis. Illustrative case

Letchuman¹,

Guillotte²,

Lundy³

et al. 2022

Journal of Neurosurgery: Case Lessons

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BACKGROUND Intracranial tuberculomas are rare entities commonly seen only in low- to middle-income countries where tuberculosis remains endemic. Furthermore, following adequate treatment, the development of intracranial spread is uncommon in the absence of immunosuppression. OBSERVATIONS A 22-year-old man with no history of immunosuppression presented with new-onset seizures in the setting of miliary tuberculosis status post 9 months of antitubercular therapy. Following a 2-month period of remission, he presented with new-onset tonic-clonic seizures. Magnetic resonance imaging demonstrated interval development of a mass concerning for an intracranial tuberculoma. After resection, pathological analysis of the mass revealed caseating granulomas within the multinodular lesion, consistent with intracranial tuberculoma. The patient was discharged after the reinitiation of antitubercular medications along with a steroid taper. LESSONS To the best of the authors’ knowledge, this case represents the first instance of intracranial tuberculoma occurring after the initial resolution of a systemic tuberculosis infection. The importance of retaining a high level of suspicion when evaluating these patients for seizure etiology is crucial because symptoms are rapidly responsive to resection of intracranial tuberculoma masses. Furthermore, it is imperative for surgeons to recognize the isolation steps necessary when managing these patients within the operating theater and inpatient settings.

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Section: Discussionmentioning

confidence: 99%

Intracranial tuberculoma: a rare complication of extrapulmonary tuberculosis. Illustrative case

Letchuman¹,

Guillotte²,

Lundy³

et al. 2022

Journal of Neurosurgery: Case Lessons

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“…The incidence of tuberculomas in tuberculous meningitis is believed to be between 4% and 28%. Unlike in adults, pediatric tuberculoma with intraventricular localization is extremely rare, with only 5 cases involving pediatric patients (tuberculomas related to the lateral ventricle, third ventricle, and thalamus) reported to our knowledge, and no cases of intra-fourth-ventricular tuberculoma have been previously described [6][7][8][9][10][11][12][13][14]. We note that a large tuberculoma can resemble a brain tumor that compresses the surrounding brain tissue, resulting in symptoms associated with intracranial hypertension, such as headache, vomiting, and nausea [6][7][8][9][10][11][12][13][14][15][16][17] that were found in the present case.…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, the presence of AFB within the biopsy sample should be investigated. The tissue sample should be cultured to confirm the growth of M. tuberculosis [4][5][6][7][8][9][10][11][12][13][14][15][16][17].…”

Section: Discussionmentioning

confidence: 99%

A giant fourth-ventricular tuberculoma mimicking a primary posterior fossa tumor

Duc

2021

Asian Biomedicine

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Typically, an intracranial tuberculoma occurs within the brain parenchyma. Intraventricular tuberculomas are rare in the absence of systemic tuberculosis (TB), and the differential diagnosis between tuberculoma and other lesions, such as primary brain tumors, can be difficult. We report an extremely unusual case of solitary fourth-ventricular tuberculoma, which occurred in a 3-year-old female patient, with no indication of TB. This lesion appeared as a primary intraventricular tumor in the fourth ventricle in both clinical and radiological examinations. In this scenario, a surgical treatment option was pursued. Histopathological testing supported the diagnosis of tuberculoma. The patient was subsequently treated with 18 months’ therapy for tuberculous, without adverse events.

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“…A variety of treatment modalities had been attempted, as shown in Table 1 . Five authors opted for prior surgical excision especially when the diagnosis was doubted [ 7 - 9 , 11 - 12 ]. This was due to the rarity of the tumor location or the absence of the systemic manifestation of tuberculosis infection.…”

Section: Discussionmentioning

confidence: 99%

“…The lesion may also be imitating malignancy, as there were no specific clinical signs suggesting intraventricular tuberculoma. These patients were started on anti-tuberculosis treatment after a histopathology study confirmed tuberculoma [ 7 - 9 , 11 ].…”

Section: Discussionmentioning

confidence: 99%

Intraventricular Tuberculoma with Profound Visual Loss: A Case Report and Literature Review

Tengku-Fatishah

Besari

Tharakan

et al. 2018

Cureus

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Intracranial tuberculoma is a rare manifestation of tuberculosis involving the central nervous system. The involvement of the ventricular system is extremely uncommon. We describe a young woman with bilateral papilledema secondary to intraventricular tuberculoma with hydrocephalus. She was treated with anti-tuberculosis therapy and intravenous dexamethasone. Her visual acuity deteriorated after one month of treatment. We provide a literature review of this uncommon ocular sequelae.

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Intraventricular Tuberculoma in a Child: A Rare Location

Cited by 8 publications

References 11 publications

Intracranial tuberculoma: a rare complication of extrapulmonary tuberculosis. Illustrative case

Intracranial tuberculoma: a rare complication of extrapulmonary tuberculosis. Illustrative case

A giant fourth-ventricular tuberculoma mimicking a primary posterior fossa tumor

Intraventricular Tuberculoma with Profound Visual Loss: A Case Report and Literature Review

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