Intraventricular pressure gradients change during the development of left ventricular hypertrophy: Effect of salvianolic acid B and beta-blocker

Ma, Danfu; Mandour, Ahmed S.; Yoshida, Tomohiko; Matsuura, Katsuhiro; Shimada, Kazumi; Kitpipatkun, Pitipat; Uemura, Akiko; Ifuku, Mayumi; Takahashi, Ken; Tanaka, Ryou

doi:10.1177/1742271x20987584

Cited by 11 publications

(19 citation statements)

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“…EA fusion has been observed in 50% of rats in the current experiment; therefore, the E/A ratio was not reported since it cannot reflect the diastolic function evaluation in the investigated groups. EA fusion is common in rats as shown previously in other studies at approximately similar heart rates [10,26]. When the HR is increased, diastasis is disturbed, leading to transmitral inflow pattern change to EA fusion pattern or half separation instead of E-A separation.…”

Section: Discussionsupporting

confidence: 79%

“…LV length was obtained from the left parasternal long-axis view. The intraventricular pressure gradient (IVPG) was calculated as follows [10,25]:…”

Section: Color M-mode Echocardiography (Cmme)mentioning

confidence: 99%

“…IVPD obtained by CMME is considered a sensitive indicator of diastolic function [6] and has the advantage of repeatability, unlike invasive catheterization. Similarly, the IVPG exerts the same properties as IVPD without being affected by the LV length [8][9][10][11]. Generally, the length of the LV, from the mitral valve to the apex, is divided into basal, mid, and apical parts, and each part has its corresponding IVPD and IVPG indices and a defined role in the diagnosis of cardiac dysfunction.…”

Section: Introductionmentioning

confidence: 99%

“…Total and mid-to-apical IVPG were identified as reliable predictors for children's survival after chemotherapy [13]. Besides, in rat models, IVPG was assessed during the development and after medication of LV hypertrophy and uremic cardiomyopathy [10,15]. This innovation is expected to minimize the experimental time and limit the number of sacrificed animals due to invasive approaches.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Loading Changes on the Intraventricular Pressure Measured by Color M-Mode Echocardiography in Rats

et al. 2021

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Evaluation of diastolic function is a pivotal challenge due to limitations of the conventional echocardiography, especially when the heart rate is rapid as in rats. Currently, by using color M-mode echocardiography (CMME), intraventricular pressure difference (IVPD) and intraventricular pressure gradient (IVPG) in early diastole can be generated and are available as echocardiographic indices. These indices are expected to be useful for the early diagnosis of heart failure (HF), especially diastolic dysfunction. There have not been any studies demonstrating changes in IVPD and IVPG in response to changes in loading conditions in rats. Therefore, the present study aims to evaluate CMME-derived IVPD and IVPG changes in rats under various loading conditions. Twenty rats were included, divided into two groups for two different experiments, and underwent jugular vein catheterization under inhalational anesthetics. Conventional echocardiography, CMME, and 2D speckle tracking echocardiography were measured at the baseline (BL), after intravenous infusion of milrinone (MIL, n = 10), and after the infusion of hydroxyethyl starch (HES, n = 10). Left ventricular IVPD and IVPG were calculated from color M-mode images and categorized into total, basal, mid-to-apical, mid, and apical parts, and the percentage of the corresponding part was calculated. In comparison to the BL, the ejection fraction, mid-to-apical IVPG, mid IVPG, and apical IVPD were significantly increased after MIL administration (p < 0.05); meanwhile, the end-diastolic volume, E-wave velocity, total IVPD, and basal IVPD were significantly increased with the administration of HES (p < 0.05). The increase in mid-to-apical IVPD, mid IVPD, and apical IVPD indicated increased relaxation. A significant increase in basal IVPD reflected volume overloading by HES. CMME-derived IVPD and IVPG are useful tools for the evaluation of various loading conditions in rats. The approach used in this study provides a model for continuous data acquisition in chronic cardiac disease models without drug testing.

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Section: Discussionsupporting

confidence: 79%

“…LV length was obtained from the left parasternal long-axis view. The intraventricular pressure gradient (IVPG) was calculated as follows [10,25]:…”

Section: Color M-mode Echocardiography (Cmme)mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effect of Loading Changes on the Intraventricular Pressure Measured by Color M-Mode Echocardiography in Rats

et al. 2021

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“…IVPD is obtained from color M-mode echocardiographic (CMME) images using Euler's equation [10]. The intraventricular pressure gradient (IVPG) can be calculated by dividing the IVPD by the length of the left ventricle (LV); consequently, unlike the IVPD, IVPG is not affected by the size of the heart [11][12][13]. Generally, the length of the LV, from the mitral valve to the apex, is divided into basal, mid, and apical parts, and each has its corresponding IVPG index.…”

Section: Introductionmentioning

confidence: 99%

The Utility of Intraventricular Pressure Gradient for Early Detection of Chemotherapy-Induced Subclinical Cardiac Dysfunction in Dogs

Matsuura

Shiraishi

Mandour

et al. 2021

Animals

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Early detection of doxorubicin (DXR)-induced cardiomyopathy (DXR-ICM) is crucial to improve cancer patient outcomes and survival. In recent years, the intraventricular pressure gradient (IVPG) has been a breakthrough as a sensitive index to assess cardiac function. This study aimed to evaluate the usefulness of IVPG for the early detection of chemotherapy-related cardiac dysfunction. For this purpose, six dogs underwent conventional, speckle tracking, and color M-mode echocardiography concomitantly with pressure-and-volume analysis by conductance catheter. The cardiac function measurements were assessed before DXR administration (baseline, Pre), at the end of treatment protocol (Post), and at 1.5 years follow-up (Post2). The result showed a significant reduction in the left ventricular end-systolic pressure-volume (Emax: 4.4 ± 0.7, 6.1 ± 1.6 vs. 8.4 ± 0.8 mmHg/mL), total-IVPG (0.59 ± 0.12, 0.62 ± 0.15 vs. 0.86 ± 0.12 mmHg), and mid-IVPG (0.28 ± 0.12, 0.31 ± 0.11 vs. 0.48 ± 0.08 mmHg), respectively in Post2 and Post compared with the baseline (p < 0.05). Mid-to-apical IVPG was also reduced in Post2 compared with the baseline (0.29 ± 0.13 vs. 0.51 ± 0.11). Meanwhile, the fraction shortening, ejection fraction, and longitudinal strain revealed no change between groups. Total and mid-IVPG were significantly correlated with Emax (R = 0.49; p < 0.05, both) but only mid-IVPG was a predictor for Emax (R2 = 0.238, p = 0.040). In conclusion, this study revealed that impairment of contractility was the initial changes observed with DXR-ICM in dogs and only IVPG could noninvasively detect subclinical alterations in cardiac function. Color M-mode echocardiography-derived IVPG could be a potential marker for the early detection of doxorubicin cardiomyopathy.

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Structural and functional condition of the heart in patients with arterial hypertension depending on A1166C-gene polymorphism of angiotensin II type 1 and T786C-promoter of endothelial NO-synthase gene

Hnizdiukh

Shmanko

2023

Med. perspekt.

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It's known that pathological changes in structural and functional condition of the heart, which are caused by arterial hypertension, trigger development of chronic heart failure and disablement of population. Nowadays, it proven that candidate genes, expression products of which participate in regulating vascular tone, have considerable influence upon development of arterial hypertension, however their role in pathogenesis of arterial hypertension has not been fully clarified, and results of the respective researches significantly vary among different populations. To determine the structural and functional state of the heart in patients with hypertension depending on the polymorphism of the A1116C gene of the angiotensin II receptor type I and the T786C promoter of the endothelial NO-synthase gene we examined 86 patients, aged from 45 to 76 years. 30 people without signs of hypertension were in the control group. The structural and functional state of the heart was assessed by cardiac ultrasound according to standard methods. Studies of the A1166C allelic polymorphism of the angiotensin II receptor gene type 1 and the T786C promoter of the eNOS gene were performed by polymerase chain reaction with electrophoretic detection of results. Analysis of cardiac ultrasound showed, that in the patients – carriers of C-allele of both studied genes (AС+СС and TC+CC) left ventricular ejection fraction tended to decrease. We found a bigger thickness of the posterior wall of the left ventricle in patients with CC genotype compared to carriers of AA genotype A1166C – (1.3±0.07) cm vs. (1.1±0.05) cm (p<0.005). The mass of the left ventricular myocardium index in the group of patients with the genotype AC and CC was (157.5±7.3) g/m2 and (161.5±7.1)) g/m2, respectively, being by 16.7% and 19.6% more than in carriers of AA genotype of the AGTR1 gene. In the groups of patients-carriers of C-allele (TC+CC) of the eNOS gene the mass of the left ventricular myocardium index values were (155.2±11.4)) g/m2 and (158.4±7.9)) g/m2, respectively, which is by 5.4% and 7.5% more than in carriers of TT genotype. The mean size of the left atrium was significantly higher in patients who had AC and CC genotype of the AGTR1 gene, as well as TC and CC genotype of the eNOS gene compared with the control group. Carriers of C-allele (AC+CC genotype) of AGTR1 gene polymorphism had clearly bigger sizes of the left atrium, as compared to homozygotes by A-allele. The severity of diastolic dysfunction was higher in carriers of the CC genotype of the AGTR1 gene and the eNOS gene than in heterozygotes of the studied genes by 4.3% and 3.3%, respectively. The research shows that inheritance of CC genotype for A1166C polymorphism of the the angiotensin II type 1 receptor gene and of CC T786C polymorphism in the promoter of eNOS gene is associated with more noticeable changes in structural and functional heart condition among patients with arterial hypertension.

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Intraventricular pressure gradients change during the development of left ventricular hypertrophy: Effect of salvianolic acid B and beta-blocker

Cited by 11 publications

References 40 publications

Effect of Loading Changes on the Intraventricular Pressure Measured by Color M-Mode Echocardiography in Rats

Effect of Loading Changes on the Intraventricular Pressure Measured by Color M-Mode Echocardiography in Rats

The Utility of Intraventricular Pressure Gradient for Early Detection of Chemotherapy-Induced Subclinical Cardiac Dysfunction in Dogs

Structural and functional condition of the heart in patients with arterial hypertension depending on A1166C-gene polymorphism of angiotensin II type 1 and T786C-promoter of endothelial NO-synthase gene

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