Intraventricular metastatic melanoma: A case report and review of the literature

Abstract

Intraventricular melanoma is a very rare and highly malignant disease. Safe resection is the mainstay of treatment, but no standard guidelines exist for adjuvant therapy. Early histologic and molecular diagnosis is key for improved survival.

Intraventricular Metastatic Melanomas: Two Case Reports

“…The typical imaging characteristics are hyperdense avidly enhancing masses on head CT scans as well as T1 enhancement on brain MRIs [8]. Typically, intraventricular melanomas tend to favour the lateral ventricles, however, rarely, the third ventricle occurrence has been reported as in our first case [6]. Overall management relies on the patient Karnofsky performance scale (KPS) score, the lesion location and accessibility, followed by systemic adjuvant therapy.…”

“…Intraventricular melanoma metastasis is rare and up to date, there are fifteen reported cases in the literature [6]. The primary site of origin tends to be the skin and in extreme circumstances primary CNS melanocytes.…”

“…In up to 14% of cases of metastatic melanoma, in general, the primary site can be difficult to localize due to intraocular or GI mucosa origin [7]. The most common presenting symptoms are headache, nausea and vomiting which can be signs of early hydrocephalus [6]. The typical imaging characteristics are hyperdense avidly enhancing masses on head CT scans as well as T1 enhancement on brain MRIs [8].…”

“…Furthermore, BRAF inhibitors can be useful in tumors with BRAF oncogene mutation, however, this is still under investigation [10]. Despite the current advancement, patient survival is poor in all reported cases [6]. tubular retractor system (Medtronic) and the overpass technique with image guidance was performed [5].…”