Intraventricular hemorrhage in newborns weighing &lt;1500 g: Epidemiology and short-term clinical outcome in a resource-poor setting

Adegoke, Samuel Ademola; Ayoola, Oluwagbemiga Oluwole; Kuti, Bankole Peter; Tinuade, Ogunlesi

doi:10.4103/1755-6783.145013

Cited by 17 publications

(25 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our results show that neonates with GA of <32 weeks had increased odds of having both mild and severe IVH, in keeping with other studies from HICs and LICs (9,10,12,13,18,28) . Birthweight was not shown to be associated with IVH, which is contrary to most ndings from HICs but in keeping with some studies in Africa (5,11,12,17) .…”

Section: Risk Factorssupporting

confidence: 92%

“…In contrast, two studies from Nigeria found lower rates of IVH than this study. One looked prospectively at 87 neonates weighing <1500g and found a 24.1% prevalence of IVH (9) . This lower rate may be because each infant was only scanned once within the rst week (range 60 hours to 7 days), therefore it is likely that some IVH will have occurred after the single scan, thus lowering the apparent prevalence.…”

Section: Discussionmentioning

confidence: 99%

“…It was not shown to be associated with low grade IVH, however the sample was too small to determine the relationship with high grade IVH when adjusted for GA, sex and weight. Whilst vaginal delivery is a recognised risk factor for high grade IVH in HICs, this nding has not been replicated in studies from LICs in sub-Saharan Africa (9,10,12,29,30) . This may be related to the timing and indication for Caesarean differing.…”

Section: Risk Factorsmentioning

confidence: 97%

“…In high income countries (HICs), IVH has been shown to contribute signi cantly to both mortality and cognitive and motor neurological impairment in premature and LBW neonates (4,(6)(7)(8). However, data regarding the incidence, risk factors and complications of IVH in LICs are scarce (9)(10)(11)(12). This study on IVH is one of the rst studies in LBW neonates in sub-Saharan Africa and the rst in east Africa.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Intraventricular haemorrhage in a Ugandan cohort of low birth weight neonates: The IVHU study

MacLeod

Paulson²,

Okalany

et al. 2020

Preprint

View full text Add to dashboard Cite

Background Globally, 15 million neonates are born prematurely every year, over half in low income countries (LICs). Premature and low birth weight neonates have a higher risk of intraventricular haemorrhage (IVH). There are minimal data regarding IVH in sub-Saharan Africa. This study aimed to examine the incidence, severity and timing of and modifiable risk factors for IVH amongst low-birth-weight neonates in Uganda.Methods This is a prospective cohort study of neonates with birthweights of ≤2000g admitted to a neonatal unit (NNU) in a regional referral hospital in eastern Uganda. Maternal data were collected from interviews and medical records. Neonates had cranial ultrasound (cUS) scans on the day of recruitment and days 3, 7 and 28 after birth. Risk factors were tabulated and are presented alongside odds ratios (ORs) and adjusted odds ratios (aORs) for IVH incidence. Outcomes included incidence, timing and severity of IVH and 28-day survival. Results Overall, 120 neonates were recruited. IVH was reported in 34.2% of neonates; 19.2% had low grade (Papile grades 1-2) and 15% had high grade (Papile grades 3-4). Almost all IVH (90.2%) occurred by day 7, including 88.9% of high grade IVH. Of those with known outcomes, 70.4% (81/115) were alive on day 28 and survival was not associated with IVH. We found that vaginal delivery, gestational age (GA) <32 weeks, resuscitation in the NNU and being small for gestational age (SGA, <10th centile) increased the odds of IVH. Of the 6 neonates who received 2 doses of antenatal steroids, none had IVH. Conclusion In this resource limited NNU in eastern Uganda, more than a third of neonates born weighing ≤2000g had an IVH and the majority of these occurred by day 7. We found that vaginal birth, earlier gestation, being SGA and need for resuscitation after admission to the NNU increased the risk of IVH. This study had a high rate of SGA neonates and the risk factors and relationship of these factors with IVH in this setting needs further investigation. The role of antenatal steroids in the prevention of IVH in LICs also needs urgent exploration.

show abstract

Section: Risk Factorssupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Risk Factorsmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Intraventricular haemorrhage in a Ugandan cohort of low birth weight neonates: The IVHU study

MacLeod

Paulson²,

Okalany

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…14,15 It was also shown by Adegoke SA et al that neonatal sepsis brings an increased risk for IVH in VLBW babies. 16 Hence neonatal sepsis and hypotension in these preterm babies pose the infant at great risk of intraventricular haemorrhage which increases the morbidity and mortality in this population significantly.…”

Section: Outcomementioning

confidence: 99%

Intraventricular haemorrhage in very preterm neonates

Kapoor

Sharma

Sapare³

et al. 2018

Int J Contemp Pediatr

View full text Add to dashboard Cite

Background: The objective of the current study was to evaluate the incidence of intraventricular haemorrhage and its associated risk factors in preterm neonates.Methods: This cohort study done at Neonatal Intensive Care Unit of a tertiary care hospital in south India enrolled 104 preterm neonates with either gestational age <32weeks and/or birth weight <1500 grams at birth. These babies were serially screened for intraventricular haemorrhage by doing a neurosonogram on day3 and day 14 of life.Results: Incidence of IVH was found to be 18.2%. Amongst these cases 52.6% babies had Grade I, 36.8% babies had Grade II and 10.6% babies had Grade III intraventricular hemorrhage with ventriculomegaly, as per Papile grading system. It was seen that hypotension needing use of inotropes and neonatal sepsis were significantly associated with IVH.Conclusions: The incidence of IVH in babies born with gestational age <32weeks and/or birth weight <1500 grams was 18.2% in our study. Neonatal sepsis and hypotension requiring use of inotropes were found to be the significant risk factors in this population.

show abstract

Preventing Perinatal Mortality in the Developing Countries

Ogunlesi

Adetoro

2021

Contemporary Obstetrics and Gynecology for Developing Countries

View full text Add to dashboard Cite

Intraventricular hemorrhage in newborns weighing <1500 g: Epidemiology and short-term clinical outcome in a resource-poor setting

Cited by 17 publications

References 0 publications

Intraventricular haemorrhage in a Ugandan cohort of low birth weight neonates: The IVHU study

Intraventricular haemorrhage in a Ugandan cohort of low birth weight neonates: The IVHU study

Intraventricular haemorrhage in very preterm neonates

Preventing Perinatal Mortality in the Developing Countries

Contact Info

Product

Resources

About