Intraventricular Haemorrhage as the First Manifestation of Congenital Cytomegalovirus Infection

Abstract

Congenital Cytomegalovirus infection (CCMV) is the most common intrauterine infection. Early diagnosis of CCMV is hindered by three factors: There is no screening programme for CMV infection in pregnant women; a high percentage of infections in neonates are asymptomatic; the clinical signs of CCMV infection are uncharacteristic. The aim of this article is to analyse the clinical picture and course of CCMV treatment in a 3-week-old newborn, analyse adverse events in 14-week-long antiviral therapy and also assess intraventricular bleeding as an early indicator for the diagnosis of CCMV.

Congenital Cytomegalovirus—History, Current Practice, and Future Opportunities

“…In a 2019 study, Faure-Bardon and colleagues found that maternal primary CMV infection in the first trimester was exclusively linked to fetal SNHL and/or neurologic morbidity. 10 Congenital CMV has also been shown to manifest with uncommon disease processes including persistent pulmonary hypertension, 11 intestinal malrotation, 12 intraventricular hemorrhage, 13 isolated secretory diarrhea, 14 nephrotoxicity, 15 and respiratory distress syndrome, 16 among others. Perinatal CMV infection can occur if the newborn is exposed during childbirth or it may be caused by exposure through breastfeeding.…”

Congenital cytomegalovirus infections in Poland – a national hospital register-based study

“…A study from two European countries that focused on CMV screening in newborns in 1977-1986 estimated the incidence of congenital infections in infants at the level of 4.6 cases per 1,000 births in Malmö, and 3.2 cases per 1,000 births in London [17]. Information on cCMV in Poland is limited or based on case reports [18,19,20,21,22]. Due to its clinical and public health importance, recent data on cCMV epidemiology in Poland should be investigated.…”