Intraventricular Dyssynchrony Predicts Mortality and Morbidity After Cardiac Resynchronization Therapy

Abstract

Myocardial dyssynchrony assessed by CMR-TSI is a powerful independent predictor of mortality and morbidity after CRT.

Fast left ventricular mass and volume assessment in mice with three‐dimensional guide‐point modeling

“…To remove the effect of this variation, the endsystolic frame for each slice was chosen manually by a single observer and the same end-systolic frames were used in both analysis methods. This method is routinely used in mouse MRI studies (2,10) and may result in an overestimation of end-systolic volume in diseased hearts with asynchronous function (15). In the future, faster scanning protocols using parallel imaging (16) will reduce the variation in heart rate between slices.…”

Cardiovascular MRI for the assessment of heart failure: Focus on clinical management and prognosis

“…There is hope, that novel CMR technology will have a superior reproducibility for the assessment of dyssynchrony and, therefore, provide greater accuracy in predicting response to CRT. Recent reports showed promising results using CMR techniques to predict response to CRT (80)(81)(82). Moreover, not only the severity of dyssynchrony, but also the amount of scar tissue and the spatial relation of myocardial scar and the site of LV pacing are important for CRT response.…”

Patient assessment for cardiac resynchronization therapy: Past, present and future of imaging techniques

“…Recently, assessment of dyssynchrony with MRI through TSI was developed using short-axis views of the LV. Construction of a polar map ( Figure 8) and derivation of a tissue synchronization index (64) were obtained from the analysis of segmental radial wall motion data. Intra-and interobserver correlations were 0.99 and 0.98, respectively.…”

“…Some of these parameters (eg, LPEI) may, however, prove to be useful and are easy to perform. We must keep in mind that the presence of LV dyssynchrony per se has prognostic implications (64). Speckle tracking is among the newer promising tools, using a simple, more global approach to dyssynchrony evaluation.…”