Intravenously Infused Stem Cells for Cancer Treatment

Mercer-Smith, Alison; Findlay, Ingrid; Bomba, Hunter N.; Hingtgen, Shawn

doi:10.1007/s12015-021-10192-0

Cited by 4 publications

(6 citation statements)

References 166 publications

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“…On the base of a great deal of reference literatures, it has been found that when MSCs are injected intravenously into the recipient body, most of them are trapped in the pulmonary capillaries [57][58][59][60][61]. In contrast, the majority of Muse cells were able to escape from the coating of lung capillaries because of Muse cells were able to selectively cluster at the site of injury by keenly sensing S1P alarm signals, a key mediator of inflammation, rather than being trapped in lung capillaries and homing in damaged tissue during intravenous injection [49].…”

Section: Majority Of Muse Cells Escape From Lung Capillary Entrapment...mentioning

confidence: 99%

“…Consistently, the ability to spontaneously differentiate into cells compatible with homing tissues in vivo after integration, even crossing oligonucleotide boundaries from mesoderm to endoderm or between ectoderm cells, is not recognized by other types of stem cells, including ESC/iPSCs and somatic stem cells such as neural and hematopoietic stem cells [59]. In addition to intravenous injection, Muse cells can also be injected locally to the site of injury.…”

Section: Majority Of Muse Cells Escape From Lung Capillary Entrapment...mentioning

confidence: 99%

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Multilineage-Differentiating Stress-Enduring Cells: A Powerful Tool for Tissue Damage Repair

Que,

Mai,

et al. 2024

Preprint

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Multilineage-differentiating stress-enduring (Muse) cells, a cell subgroup from mesenchymal stem cells (MSCs), are pluripotent cells with unique characteristics such as non-tumorigenic and pluripotent differentiation ability. After homing, Muse cells spontaneously differentiate into tissue component cells and supplement damaged/lost cells to participate in tissue repair. Importantly, Muse cells can survive in injured tissue for an extended period, stabilizing and promoting tissue repair. In addition, it has been confirmed that injection of exogenous Muse cells exerts anti-inflammatory, anti-apoptosis, anti-fibrosis, immunomodulatory, and paracrine protective effects in vivo. The discovery of Muse cells is an important breakthrough in regenerative medicine. The article provides a comprehensive review of the characteristics, sources, and potential mechanisms of Muse cells for tissue repair and regeneration. This review serves as a foundation for the further utilization of Muse cells as a key clinical tool in regenerative medicine.

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Section: Majority Of Muse Cells Escape From Lung Capillary Entrapment...mentioning

confidence: 99%

Section: Majority Of Muse Cells Escape From Lung Capillary Entrapment...mentioning

confidence: 99%

Multilineage-Differentiating Stress-Enduring Cells: A Powerful Tool for Tissue Damage Repair

Que,

Mai,

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…In contrast, the majority of Muse cells were able to escape from the coating of lung capillaries because of Muse cells were able to selectively cluster at the site of injury by keenly sensing S1P alarm signals, a key mediator of inflammation, rather than being trapped in lung capillaries and homing in damaged tissue during intravenous injection (Yamada et al, 2018). Consistently, the ability to spontaneously differentiate into cells compatible with homing tissues in vivo after integration, even crossing oligonucleotide boundaries from mesoderm to endoderm or between ectoderm cells, is not recognized by other types of stem cells, including ESC/iPSCs and somatic stem cells such as neural and hematopoietic stem cells (Mercer-Smith et al, 2021). In addition to intravenous injection, Muse cells can also be injected locally to the site of injury.…”

Section: The Escape Of Muse Cells From Pulmonary Capillaries Might Be...mentioning

confidence: 99%

“…On the base of a great deal of reference literatures, it has been found that when MSCs are injected intravenously into the recipient body, most of them are trapped in the pulmonary capillaries ( Barbash et al, 2003 ; Li et al, 2008 ; Brooks et al, 2018 ; Mercer-Smith et al, 2021 ). In contrast, the majority of Muse cells were able to escape from the coating of lung capillaries because of Muse cells were able to selectively cluster at the site of injury by keenly sensing S1P alarm signals, a key mediator of inflammation, rather than being trapped in lung capillaries and homing in damaged tissue during intravenous injection ( Yamada et al, 2018 ).…”

Section: Muse Cell Repairs the Location Of The Damagementioning

confidence: 99%

Multilineage-differentiating stress-enduring cells: a powerful tool for tissue damage repair

Que,

Mai,

et al. 2024

Front. Cell Dev. Biol.

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Multilineage-differentiating stress-enduring (Muse) cells are a type of pluripotent cell with unique characteristics such as non-tumorigenic and pluripotent differentiation ability. After homing, Muse cells spontaneously differentiate into tissue component cells and supplement damaged/lost cells to participate in tissue repair. Importantly, Muse cells can survive in injured tissue for an extended period, stabilizing and promoting tissue repair. In addition, it has been confirmed that injection of exogenous Muse cells exerts anti-inflammatory, anti-apoptosis, anti-fibrosis, immunomodulatory, and paracrine protective effects in vivo. The discovery of Muse cells is an important breakthrough in the field of regenerative medicine. The article provides a comprehensive review of the characteristics, sources, and potential mechanisms of Muse cells for tissue repair and regeneration. This review serves as a foundation for the further utilization of Muse cells as a key clinical tool in regenerative medicine.

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“…When considering cell surface markers, commonly used therapeutic agents include surface antigens (SAs) and immune checkpoint blockades (ICBs); alternatively, the aspects of immunotherapy engaged in pathway interactions include inhibitors for Wnt, Notch, Hedgehog, PI3K, and other metabolism or niche mechanisms [ 90 , 265 , 333 ]. While the focus of this paper is on the optimization of current NC-based systems in targeting stem cell markers and pathways, alternative CSC applications like CSCs as vehicles of delivery [ 238 , 334 , 335 ] or even infused stem therapy [ 336 ] cannot be dismissed. As such, MSCs in the context of therapeutic carriers are gaining rapid popularity as a strategy to ensure ameliorated side-effects on account of improved biocompatibility [ 332 , 337 ].…”

Section: Current Regimens For Cancer Therapymentioning

confidence: 99%

Cancer Stem Cells and the Tumor Microenvironment: Targeting the Critical Crosstalk through Nanocarrier Systems

Nayak

Warrier

Kumar

2022

Stem Cell Rev and Rep

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The physiological state of the tumor microenvironment (TME) plays a central role in cancer development due to multiple universal features that transcend heterogeneity and niche specifications, like promoting cancer progression and metastasis. As a result of their preponderant involvement in tumor growth and maintenance through several microsystemic alterations, including hypoxia, oxidative stress, and acidosis, TMEs make for ideal targets in both diagnostic and therapeutic ventures. Correspondingly, methodologies to target TMEs have been investigated this past decade as stratagems of significant potential in the genre of focused cancer treatment. Within targeted oncotherapy, nanomedical derivates—nanocarriers (NCs) especially—have emerged to present notable prospects in enhancing targeting specificity. Yet, one major issue in the application of NCs in microenvironmental directed therapy is that TMEs are too broad a spectrum of targeting possibilities for these carriers to be effectively employed. However, cancer stem cells (CSCs) might portend a solution to the above conundrum: aside from being quite heavily invested in tumorigenesis and therapeutic resistance, CSCs also show self-renewal and fluid clonogenic properties that often define specific TME niches. Further scrutiny of the relationship between CSCs and TMEs also points towards mechanisms that underly tumoral characteristics of metastasis, malignancy, and even resistance. This review summarizes recent advances in NC-enabled targeting of CSCs for more holistic strikes against TMEs and discusses both the current challenges that hinder the clinical application of these strategies as well as the avenues that can further CSC-targeting initiatives. Graphical abstract Central role of CSCs in regulation of cellular components within the TME

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Intravenously Infused Stem Cells for Cancer Treatment

Cited by 4 publications

References 166 publications

Multilineage-Differentiating Stress-Enduring Cells: A Powerful Tool for Tissue Damage Repair

Multilineage-Differentiating Stress-Enduring Cells: A Powerful Tool for Tissue Damage Repair

Multilineage-differentiating stress-enduring cells: a powerful tool for tissue damage repair

Cancer Stem Cells and the Tumor Microenvironment: Targeting the Critical Crosstalk through Nanocarrier Systems

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