1992
DOI: 10.1016/s0022-3476(05)80619-5
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Intravenously administered labetalol for treatment of hypertension in children

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Cited by 49 publications
(20 citation statements)
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“…It should also be used with caution in children with diabetes. Caution should also be exercised in children with brain injury as they are more likely to develop hypotension [62,63]. Labetalol has the potential to worsen hyperkalemia, and this has to be considered in children with impaired kidney function.…”
Section: Management Of Hypertensive Crisismentioning
confidence: 99%
“…It should also be used with caution in children with diabetes. Caution should also be exercised in children with brain injury as they are more likely to develop hypotension [62,63]. Labetalol has the potential to worsen hyperkalemia, and this has to be considered in children with impaired kidney function.…”
Section: Management Of Hypertensive Crisismentioning
confidence: 99%
“…Administered intravenously, it is this vasodilatation which accounts for labetalol's efficacy in the treatment of severe hypertension. The hypotensive effects of a single dose of intravenous labetalol appear within 2-5 min after administration, peak at 5-15 min, and last up to 2-4 h. Intravenously administered labetalol has been extensively studied in adults with severe hypertension [37], and case series of successful use in children with severe hypertension have been published [5,38]. Adverse reactions are those expected from a beta-adrenergic blocker, including bradycardia and bronchospasm.…”
Section: Intravenous Agents Currently Used In Children With Severe Hymentioning
confidence: 99%
“…It has a relatively slow onset of action (5-10 min), and hypotension can last for up to 4 h [17]. Despite its wide use in hypertensive emergencies in children, published informations are very limited and mainly based on small retrospective trials and case reports [18][19][20][21][22][23][24][25].…”
Section: Resultsmentioning
confidence: 99%