Intravenous Vitamin C in Adults with Sepsis in the Intensive Care Unit

Lamontagne, François; Masse, Marie-Hélène; Ménard, Julie; Sprague, Sheila; Pinto, Ruxandra; Heyland, Daren K.; Cook, Deborah J.; Battista, Marie-Claude; Day, Andrew G.; Guyatt, Gordon; Kanji, Salmaan; Parke, Rachael; McGuinness, Shay; Vijayaraghavan, Bharath-Kumar Tirupakuzhi; Annane, Djillali; Cohen, Dian; Arabi, Yaseen M.; Bolduc, Brigitte; Marinoff, Nicole; Rochwerg, Bram; Millen, Tina; Meade, Maureen O.; Hand, Lori; Watpool, Irene; Porteous, Rebecca; Young, Paul; D’Aragon, Frédérick; Belley‐Côté, Emilie P.; Carbonneau, Élaine; Clarke, France; Maslove, David; Hunt, Miranda; Chassé, Michaël; Lebrasseur, Martine; Lauzier, François; Mehta, Sangeeta; Quiroz-Martinez, Hector; Rewa, Oleksa; Charbonney, Emmanuel; Seely, Andrew J. E.; Kutsogiannis, Demetrios J; Leblanc, Rémi; Mekontso-Dessap, Armand; Mele, Tina; Turgeon, Alexis F.; Wood, G. Christopher; Kohli, Sandeep S; Shahin, Jason; Twardowski, Paweł; Adhikari, Neill K. J.

doi:10.1056/nejmoa2200644

Cited by 185 publications

(268 citation statements)

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“…Septic patients admitted to the intensive care unit (ICU) received either high-dose vitamin C or placebo. As opposed to placebo, vitamin C was associated with an increased occurrence of the primary endpoint (persistent organ dysfunction plus death) [ 1 ]. While these results may suggest the end of the vitamin C story, several aspects suggest that LOVIT is just one piece of the puzzle and that the baby should not be thrown out with the bathwater.…”

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confidence: 99%

Intravenous vitamin C in adults with sepsis in the intensive care unit: still LOV’IT?

et al. 2022

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confidence: 99%

Intravenous vitamin C in adults with sepsis in the intensive care unit: still LOV’IT?

et al. 2022

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“…Initial optimism for this therapy, based on observational data, has been tempered by meta-analyses of RCTs, 32 including the recently published LOVIT (Lessening Organ Dysfunction with Vitamin C) trial. 33 Bicarbonate As in the 2016 Guidelines, the panel issued a weak recommendation against (HFNO) over noninvasive ventilation (NIV) in patients with sepsis-induced hypoxemic respiratory failure. This was based on an RCT that compared HFNO directly with NIV in septic patients with hypoxemic respiratory failure.…”

Section: Vitamin Cmentioning

confidence: 99%

Surviving Sepsis Campaign Guidelines 2021: highlights for the practicing clinician

Oczkowski¹,

Alshamsi²,

Belley‐Côté³

et al. 2022

Polish Archives of Internal Medicine

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ensure they would be applicable in both high-and low-resource settings. Secondly, while remaining intensive care unit (ICU)-focused, the 2021 Guidelines acknowledged the long-term impact of sepsis, including physical, psychological, and mental problems experienced by sepsis survivors and their families. A new section of the Guidelines was developed to address long-term outcomes and goals of care in sepsis, with an expanded patient and public involvement in the panel to provide input on the Guidelines and ensure they were consistent with patient and family needs, values, and preferences for care.In this paper, we outline the noteworthy aspects of each section of the 2021 Guidelines that represent a change from previous practice, address an important clinical question not previously discussed, or remain an area of persistent clinical challenge. Of note, we do not address issues related to the COVID-19 pandemic, Introduction Despite advances in rapid recognition and resuscitation, sepsis remains a major cause of morbidity and mortality worldwide, underscoring the need for continued research, education, and knowledge translation activities. 1,2 Since its inception in 2002, the Surviving Sepsis Campaign (SSC) has played a central role in improving the care of patients with sepsis. As a collaboration between the Society of Critical Care Medicine and the European Society of Intensive Care Medicine, with endorsement from many other national and international societies, the SSC Guidelines represent the currently accepted standard for sepsis care in adults. 3 The 2021 Guidelines build upon and advance the earlier versions in important ways. Firstly, they address sepsis as a global health threat. To this end, the leadership explicitly sought to increase diversity in the representative panelists as well as the recommendations themselves to

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“…Usual care treatment consists of antibiotics, infection source control, fluid resuscitation and vasopressors, with the aim of reducing the microbial burden and supporting organ function 3 . The recent Conservative versus Liberal Approach to Fluid Therapy in Septic Shock (CLASSIC) 4 and Lessening Organ Dysfunction with Vitamin C (LOVIT) 5 trials provide incremental evidence on fluid volume for resuscitation and treatment with high-dose intravenous vitamin C, respectively, in patients with sepsis (Table 1 ).…”

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confidence: 99%

“…The recent Conservative versus Liberal Approach to Fluid Therapy in Septic Shock (CLASSIC) 4 and Lessening Organ Dysfunction with Vitamin C (LOVIT) 5 trials provide incremental evidence on fluid volume for resuscitation and treatment with high-dose intravenous vitamin C, respectively, in patients with sepsis (Table 1 ).…”

mentioning

confidence: 99%