Intravenous versus oral paracetamol for postoperative analgesia: A systematic review

Stagg, Katherine

doi:10.1177/1750458920950652

Cited by 3 publications

(3 citation statements)

References 13 publications

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“…This study reported almost 11 % non-conformity of Paracetamol use in terms of dosage, duration and contraindication. This result can be related to the systematic use of Paracetamol in hospitals based on its beneficial effect of reducing the pain score of 0.5 in postoperative patients 30 . Nevertheless, when assessing the contraindication of non-steroidal anti-inflammatory drugs, only 2 % of non-conformity was noted.…”

Section: Discussionmentioning

confidence: 90%

Assessment of the conformity of analgesics prescribed in postoperative patients: a cross-sectional audit

Barada

Hatem

Kaaki

et al. 2023

PMJUA

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Introduction: Post-operative pain management is crucial and patients can experience moderate to severe pain after surgery. The aims of this study were to assess the conformity to guidelines of analgesic prescription after major surgeries and evaluate the different predictors of non-conformity. Methods: A cross-sectional study was conducted on 497 hospitalized patients undergoing major surgeries between November 2018 and June 2019 using the data from their medical charts. Results: In total, 227 patients had a previous medical history. A significant relationship was noted between conformity, age, and length of stay where patients older than 65 had a higher degree of non-conformity compared to younger patients. Almost 90% of the analgesic were conforming in terms of dosage, treatment duration, choice and contraindication. Conclusion: This study highlights the importance of adequate pain management and its influence on the quality of life of patients, as well as the importance of age, comorbidities and pain intensity as predictors to reach a higher level of conformity.

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Section: Discussionmentioning

confidence: 90%

Assessment of the conformity of analgesics prescribed in postoperative patients: a cross-sectional audit

Barada

Hatem

Kaaki

et al. 2023

PMJUA

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“…Paracetamol powszechnie stosowany jako lek przeciwbólowy może być użyty w premedykacji zarówno drogą dożylną, jak i doustną. Sugeruje się, że obie formy mają podobny efekt działania [61]. Wydaje się, że w drobnych zabiegach operacyjnych paracetamol może być równie skuteczny jak opioidy, co ważne -nie niosąc skutków ubocznych, jak np.…”

Section: Leki Przeciwbóloweunclassified

Application of anesthetic premedication in palliative medicine

Prusator-Żędzian¹,

Jasiewicz²,

Kościuczuk³

et al. 2021

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as well as gabapentinoids and painkillers, are recommended drugs. A wide range of other medications is used for the premedication of patients in palliative medicine. Giving up premedication before painful procedures and surgery in the group of palliative medicine patients is not recommended. The benefits of premedication in the form of anxiolytic and analgesic effects outweigh the potential side effects of premedication drugs.

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“…Previously, paracetamol was manufactured for oral and rectal use; however, an intravenous (IV) formulation has also been available. A previous systematic review comparing the analgesic efficacy of IV paracetamol to oral paracetamol reported that IV paracetamol offered better postoperative pain than oral paracetamol [ 4 ]. On the contrary, Mallama and colleagues found no difference in postoperative pain between the IV and oral paracetamol groups [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Unlocking the Optimal Analgesic Potential: A Systematic Review and Meta-Analysis Comparing Intravenous, Oral, and Rectal Paracetamol in Equivalent Doses

Ibrahim¹,

Gebril²,

Nasr³

et al. 2023

Cureus

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Paracetamol (acetaminophen) is an extensively used analgesic for acute and chronic pain management. Currently, paracetamol is manufactured for oral, rectal, and intravenous (IV) use. Research has shown varied results on the analgesic properties of IV paracetamol compared to oral and rectal paracetamol; however, research on the same doses of paracetamol is limited. Therefore, this review was constructed to explore the analgesic properties of IV paracetamol compared with oral and rectal paracetamol administered in equivalent doses. A broad and thorough literature search was performed on five electronic databases, including PubMed, ScienceDirect, Medline, Scopus, and Google Scholar. Statistical analysis of all outcomes in our review was then performed using the Review Manager software. Outcomes were categorized as primary (pain relief and time to request rescue analgesia) and secondary (adverse events after analgesia). An extensive quality appraisal was also done using the Review Manager software’s Cochrane risk of bias tool. The literature survey yielded 2,945 articles, of which 12 were used for review and analysis. The pooled analysis for patients undergoing surgical procedures showed that IV paracetamol had statistically similar postoperative pain scores at two (mean difference (MD) = -0.14; 95% confidence interval (CI) -0.58-0.29; p = 0.51), 24 (MD = 0.09; 95% CI = -0.02-0.21; p = 0.12), and 48 (MD = 0.04; 95% CI = -0.08-0.16; p = 0.52) hours as oral paracetamol. Similarly, the data on time to rescue analgesia showed no considerable difference between the IV and oral paracetamol groups (MD = -1.58; 95% CI = -5.51-2.35; p = 0.43). On the other hand, the pooled analysis for patients presenting non-surgical acute pain showed no significant difference in the mean pain scores between patients treated with IV and oral paracetamol (MD = -0.35; 95% CI = -2.19-1.48; p = 0.71). Furthermore, a subgroup analysis of analgesia-related adverse events showed that the incidences of vomiting/nausea and pruritus did not differ between patients receiving IV and oral paracetamol (odds ratio (OR) = 0.71; 95% CI = 0.45-1.11; p = 0.13 and OR = 0.48; 95% CI = 0.18-1.29; p = 0.05, respectively). A review of information from two trials comparing equal doses of IV and rectal paracetamol suggested that the postoperative pain scores were statistically similar between the groups. IV paracetamol is not superior to oral or rectal paracetamol administered in equal doses. Therefore, we cannot recommend or refute IV paracetamol as the first-line analgesia for acute and postoperative pain.

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Intravenous versus oral paracetamol for postoperative analgesia: A systematic review

Cited by 3 publications

References 13 publications

Assessment of the conformity of analgesics prescribed in postoperative patients: a cross-sectional audit

Assessment of the conformity of analgesics prescribed in postoperative patients: a cross-sectional audit

Application of anesthetic premedication in palliative medicine

Unlocking the Optimal Analgesic Potential: A Systematic Review and Meta-Analysis Comparing Intravenous, Oral, and Rectal Paracetamol in Equivalent Doses

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