Intravenous sufentanil-midazolam versus sevoflurane anaesthesia in medetomidine pre-medicated Himalayan rabbits undergoing ovariohysterectomy

Hedenqvist, Patricia; Jensen-Waern, Marianne; Fahlman, Åsa; Hagman, Ragnvi; Edner, Anna

doi:10.1111/vaa.12207

Cited by 7 publications

(5 citation statements)

References 22 publications

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“…This study indicated that dexmedetomidine did not affect postoperative recovery in patients following hysterectomy, possibly related to its antisympathetic, sedative, and analgesic effects, and it also had no significant effect on normal breathing. 5 In accordance with the current results, Silva-Jr et al. 27 reported that dexmedetomidine had a better sedative effect compared with benzodiazepines, which reduced restlessness in surgical patients during the recovery period and was conducive to postoperative recovery.…”

Section: Discussionsupporting

confidence: 89%

“…Previous studies found that increasing anesthesia in the perioperative period may affect the quality of recovery from anesthesia, and that dexmedetomidine may improve anesthesia recovery. 5 However, although dexmedetomidine does not inhibit the respiratory system and rarely causes apnea, some studies found that it could lead to hypoxia and hypercapnia, and may have hemodynamic effects such as hypertension and hypotension. 6 …”

Section: Introductionmentioning

confidence: 99%

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Effect of dexmedetomidine on hemodynamics in patients undergoing hysterectomy: a meta-analysis and systematic review

Zhang

2021

J Int Med Res

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Objective We conducted a meta-analysis and systematic review to evaluate the effects of dexmedetomidine on the hemodynamics of patients undergoing hysterectomy. Methods We searched the Medline, Embase, and Cochrane Central Register of Controlled Trials databases for clinical randomized controlled trials (RCTs) that allowed direct or indirect comparisons of hemodynamic indicators. We also searched nine English-language databases up to April 2021 to identify relevant research. The Cochrane risk-of-bias tool for RCTs was applied to assess the methodological quality of the eligible studies. The meta-analysis was conducted using RevMan 5.4 software. Results Nine trials were included in this systematic review. The effect of dexmedetomidine on heart rate during surgery was significantly smaller than that of other sedatives. Intraoperative systolic and diastolic blood pressure and mean arterial pressure were more stable in the dexmedetomidine group compared with the control group. The postoperative modified Observer’s Assessment of Alertness Score was also better in the dexmedetomidine compared with the control group. Conclusions Dexmedetomidine increases hemodynamic stability in patients undergoing hysterectomy, reduces the cardiovascular stress response during surgery, and effectively prevents postoperative adverse reactions, with good safety.

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Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Effect of dexmedetomidine on hemodynamics in patients undergoing hysterectomy: a meta-analysis and systematic review

Zhang

2021

J Int Med Res

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“…Medetomidine is widely used in many countries for sedation in a variety of animal species and administered intramuscularly (IM) at 100–500 μg/kg in combination with other sedatives, analgesics, and/or injectable anesthetics in rabbits [ 1 , 8 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 19 , 20 , 21 , 23 , 24 , 25 , 26 , 30 ]. Kirihara et al .…”

Section: Discussionmentioning

confidence: 99%

The sedative effect of intranasal administration of medetomidine using a mucosal atomization device in Japanese White rabbits

Wei

Chen

Tamogi

et al. 2023

The Journal of Veterinary Medical Science

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To prevent aspiration in Japanese White (JW) rabbits, the maximum single volume of medetomidine administered intranasally is 0.3 mL per nostril using a mucosal atomization device (MAD). This study aimed to examine the sedative effect of intranasal administration of medetomidine using MAD in eight healthy female JW rabbits. Each rabbit received intranasal atomization (INA) of saline (Control treatment) along with three doses of 1 mg/mL medetomidine (0.3 mL to one nostril [MED0.3 treatment]; 0.3 mL each to both nostrils [MED0.6 treatment]; 0.3 mL twice to both nostrils [MED1.2 treatment]), with a washout period of at least 7 days between treatments. The actual doses of medetomidine were 82 (75-84) μg/kg (median [interquartile range]), 163 (156-168) μg/kg, and 323 (295-343) μg/kg for the MED0.3, MED0.6, and MED1.2 treatments, respectively. A medetomidine-dose dependent sedative effect was detected, and the loss of righting reflex (LRR) was achieved in one rabbit at 18 min, seven rabbits at 11 (9-18) min, and eight rabbits at 7 (4-18) min after the MED0.3, MED0.6, and MED1.2 treatments, respectively. The LRR was maintained for 63 (29-71) min and 83 (68-101) min after the MED0.6 and MED1.2 treatments, respectively. Additionally, the INA of medetomidine produced a significant dose-dependent cardiorespiratory depression including a decrease in pulse rate, respiratory rate, percutaneous oxygen saturation, and arterial partial pressure of oxygen, and an increase in arterial partial pressure of carbon dioxide in the rabbits.

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“…In a study from 2020 ( 21 ) it was shown that the IBP measurement system is more prone to error with higher compared to lower heart rates and that at high heart rates (120 beats per minute) the demands on the system become more stringent. Heart rates in rabbits are usually higher than 120 beats per minute, even when cardiodepressive drugs have been used for sedation or anaesthesia ( 22 ). This could have influenced the accuracy of the invasive measurement.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of agreement between invasive and non-invasive blood pressure measurement using the PetMAP™ device in rabbits

et al. 2023

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BackgroundMeasurement of arterial blood pressure is recommended in anaesthetized animals to guide perioperative treatment. Invasive blood pressure measurement is considered the gold standard, however it is also technically challenging, requires specialised equipment and carries certain risks. For these reasons, non-invasive blood pressure measurement devices are commonly used and are expected to provide accurate and reliable results. This requirement is particularly true for rabbits, in whom peri-anaesthetic hypotension is commonly observed and in whom perioperative mortality remains disproportionally high. Several authors have compared different non-invasive devices with invasive measurements in rabbits and have reported contrasting results. However, to date no comparison between invasive measurements and the PetMAP™ device, that has been designed specifically for veterinary medicine, has been reported.Aim and hypothesisThe aim of the study was the comparison of invasive blood pressure measurement with PetMAP™ in rabbits. We hypothesised that PetMAP™ would show acceptable agreement with the invasive measurements according to the American College of Veterinary Internal Medicine guidelines.Materials and methodsSixteen client-owned rabbits presenting for various surgical interventions were included in the study. Invasive measurements were performed by cannulation of an auricular artery. The PetMAP™ cuff was applied distal to the elbow according to the manufacturer’s guidelines. For each measurement with PetMAP™, three invasive blood pressure values were recorded. The mean of the three invasive values was compared with one value measured with PetMAP™.ResultsData collected from 16 rabbits were used for statistical analysis. In the clinical setting, the PetMAP™ device showed significant overestimation of systolic, diastolic and mean arterial pressure, which were measured in the auricular artery. In addition, the bias was not constant, implying that the device poorly predicted changes in blood pressure.ConclusionThe PetMAP™ device did not meet any of the American College of Veterinary Internal Medicine recommendations.

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Intravenous sufentanil-midazolam versus sevoflurane anaesthesia in medetomidine pre-medicated Himalayan rabbits undergoing ovariohysterectomy

Abstract: Anaesthesia with sufentanil-midazolam in medetomidine premedicated healthy rabbits is useful in the clinical and the research setting, as an alternative to sevoflurane.

Cited by 7 publications

References 22 publications

Effect of dexmedetomidine on hemodynamics in patients undergoing hysterectomy: a meta-analysis and systematic review

Effect of dexmedetomidine on hemodynamics in patients undergoing hysterectomy: a meta-analysis and systematic review

The sedative effect of intranasal administration of medetomidine using a mucosal atomization device in Japanese White rabbits

Evaluation of agreement between invasive and non-invasive blood pressure measurement using the PetMAP™ device in rabbits

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