Intravenous solid tip lead placement in telemetry implanted dogs. Part 1: Surgical methods, signal quality, and pathological endpoints

Walisser, Jacqueline A.; Mitchell, Andrea Z.; Bills, Andrew J.; Sharma, Alok; Latimer, Kenneth S.; Taschwer, Michael; Osinski, Mark A.

doi:10.1016/j.vascn.2013.04.001

Cited by 8 publications

(1 citation statement)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous publications have described telemetry transmitter 5,14,25 and VAP 15,24 implantation techniques similar to those we used. A ventral midline incision was made in the abdomen, starting at the xiphoid process extending caudally 1 to 2 cm beyond the umbilicus, and the abdomen accessed.…”

Section: Methodsmentioning

confidence: 99%

Automated Blood Sampling in a Canine Telemetry Cardiovascular Model

et al. 2021

View full text Add to dashboard Cite

Successful implementation of automated blood sampling (ABS) into a telemetry instrumented canine cardiovascular model provides simultaneous cardiovascular assessment of novel compounds while collecting multiple blood samples for analysis of drug level, cytokines, and biomarkers. Purpose-bred male Beagle dogs (n = 36) were instrumented with a dual-pressure telemetry transmitter and vascular access port. Modifications to acclimation practices, surgical procedures, and housing were required for implementation of ABS in our established cardiovascular canine telemetry colony. These modifications have increased the use and reproducibility of the model by combining early pharmacokinetic and cardiovascular studies, thus achieving both refinement and reduction from a 3R perspective. In addition, the modified model can shorten timelines and reduce the compound requirement in early stages of drug development. This telemetry–ABS model provides an efficient means to quickly identify potential effects on key cardiovascular parameters in a large animal species and to obtain a more complete pharmacokinetic–pharmacodynamic profile for discovery compounds.

show abstract

Section: Methodsmentioning

confidence: 99%