Intravenous Regional Limb Perfusion in Standing and Recumbent Horses: A Comparative Radiographic Study

Regional antibiotic perfusion through the lateral saphenous vein in two horses with septic calcaneal osteitis

“…Regarding regional perfusion, locally administered antimicrobials diffuse preferentially into the adjacent, highly vascularized, and more dependent compartments through the venous system [ 10 , 18 , 25 , 27 , 32 ]. Many studies have achieved clinically relevant antibiotic concentration in specific sites via IVRLP with various techniques [ 2 , 23 ].…”

“…In contrast, a double tourniquet placed proximal and distal to the target compartment was required to achieve those concentrations in the proximal compartments [ 15 , 20 , 28 ]. A recent study [ 10 ] revealed the possible role of gravity in sufficient vascular perfusion and distribution of the perfusate into adjacent soft tissue in the distal limbs of horses under the IVRLP procedure. Therefore, in addition to the IVRLP technique, reviewing the spatial orientation and vascularization of the tissue of interest relative to the site of infusion when IVRLP is performed is meaningful.…”