“…For the production of the ulcers, a model was selected which corresponds to a pathophysiological possibility of ulcer formation. Thus, Seronde,Konturek and others, in their studies, demonstrated that continual hyperproduction of acid represents a decisive factor in the development of experimental duodenal ulcers (4,5,6,10,13,14,15,19,24). Investigations in human subjects support this (22,24).…”